Pro-inflammatory and anti-inflammatory cytokine increases after spinal instrumentation surgery
We investigated the effects of instrumentation on postoperative inflammatory reaction and identified standard changes in serum cytokine concentrations after spinal surgery. Pro-inflammatory cytokines [interleukin (IL)-6 and IL-8] and anti-inflammatory cytokines [IL-10, IL-1 receptor antagonist (ra),...
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| Veröffentlicht in: | Journal of spinal disorders & techniques 2002-08, Vol.15 (4), p.294-300 |
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| container_title | Journal of spinal disorders & techniques |
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| creator | TAKAHASHI, Jun EBARA, Sohei KAMIMURA, Mikio KINOSHITA, Tetsuya MISAWA, Hiromichi SHIMOGATA, Mitsuhiko TOZUKA, Minoru TAKAOKA, Kunio |
| description | We investigated the effects of instrumentation on postoperative inflammatory reaction and identified standard changes in serum cytokine concentrations after spinal surgery. Pro-inflammatory cytokines [interleukin (IL)-6 and IL-8] and anti-inflammatory cytokines [IL-10, IL-1 receptor antagonist (ra), and soluble tumor necrosis factor receptors (sTNF-R) I and II] were assayed in serum from seven patients with lumbar spinal posterior decompression, six with spinal decompression and posterolateral fusion without instrumentation and seven with spinal decompression and posterolateral fusion with instrumentation. All cytokines after spinal instrumentation increased significantly more than in other groups on postoperative days 0 and 1. Seven days after SI, IL-6, -8, and -10 had normalized, but IL-1ra and sTNF-RI and sTNF-RII remained elevated. Both pro-inflammatory and anti-inflammatory cytokines were enhanced by implants in the acute phase, whereas only anti-inflammatory cytokines were enhanced by instruments in the subacute phase. |
| doi_str_mv | 10.1097/00024720-200208000-00006 |
| format | Article |
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Pro-inflammatory cytokines [interleukin (IL)-6 and IL-8] and anti-inflammatory cytokines [IL-10, IL-1 receptor antagonist (ra), and soluble tumor necrosis factor receptors (sTNF-R) I and II] were assayed in serum from seven patients with lumbar spinal posterior decompression, six with spinal decompression and posterolateral fusion without instrumentation and seven with spinal decompression and posterolateral fusion with instrumentation. All cytokines after spinal instrumentation increased significantly more than in other groups on postoperative days 0 and 1. Seven days after SI, IL-6, -8, and -10 had normalized, but IL-1ra and sTNF-RI and sTNF-RII remained elevated. Both pro-inflammatory and anti-inflammatory cytokines were enhanced by implants in the acute phase, whereas only anti-inflammatory cytokines were enhanced by instruments in the subacute phase.</description><identifier>ISSN: 1536-0652</identifier><identifier>EISSN: 1539-2465</identifier><identifier>DOI: 10.1097/00024720-200208000-00006</identifier><identifier>PMID: 12177545</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams and Wilkins</publisher><subject>Aged ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Antigens, CD - blood ; Biological and medical sciences ; C-Reactive Protein - metabolism ; Cytokines - blood ; Decompression, Surgical ; Emergency and intensive postoperative care (general aspects). Pathophysiology of surgery ; Female ; Humans ; Inflammation - blood ; Inflammation - etiology ; Intensive care medicine ; Interleukin 1 Receptor Antagonist Protein ; Interleukin-10 - blood ; Interleukin-6 - blood ; Interleukin-8 - blood ; Lumbar Vertebrae - surgery ; Male ; Medical sciences ; Middle Aged ; Orthopedic surgery ; Postoperative Period ; Prostheses and Implants - adverse effects ; Receptors, Tumor Necrosis Factor - blood ; Receptors, Tumor Necrosis Factor, Type I ; Receptors, Tumor Necrosis Factor, Type II ; Sialoglycoproteins - blood ; Spinal Diseases - blood ; Spinal Diseases - surgery ; Spinal Fusion ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Time Factors</subject><ispartof>Journal of spinal disorders & techniques, 2002-08, Vol.15 (4), p.294-300</ispartof><rights>2002 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c407t-ef3828cf34645b65819bf0083c85168b0031d115a89e8549a7753637682d000e3</citedby><cites>FETCH-LOGICAL-c407t-ef3828cf34645b65819bf0083c85168b0031d115a89e8549a7753637682d000e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13864408$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12177545$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TAKAHASHI, Jun</creatorcontrib><creatorcontrib>EBARA, Sohei</creatorcontrib><creatorcontrib>KAMIMURA, Mikio</creatorcontrib><creatorcontrib>KINOSHITA, Tetsuya</creatorcontrib><creatorcontrib>MISAWA, Hiromichi</creatorcontrib><creatorcontrib>SHIMOGATA, Mitsuhiko</creatorcontrib><creatorcontrib>TOZUKA, Minoru</creatorcontrib><creatorcontrib>TAKAOKA, Kunio</creatorcontrib><title>Pro-inflammatory and anti-inflammatory cytokine increases after spinal instrumentation surgery</title><title>Journal of spinal disorders & techniques</title><addtitle>J Spinal Disord Tech</addtitle><description>We investigated the effects of instrumentation on postoperative inflammatory reaction and identified standard changes in serum cytokine concentrations after spinal surgery. Pro-inflammatory cytokines [interleukin (IL)-6 and IL-8] and anti-inflammatory cytokines [IL-10, IL-1 receptor antagonist (ra), and soluble tumor necrosis factor receptors (sTNF-R) I and II] were assayed in serum from seven patients with lumbar spinal posterior decompression, six with spinal decompression and posterolateral fusion without instrumentation and seven with spinal decompression and posterolateral fusion with instrumentation. All cytokines after spinal instrumentation increased significantly more than in other groups on postoperative days 0 and 1. Seven days after SI, IL-6, -8, and -10 had normalized, but IL-1ra and sTNF-RI and sTNF-RII remained elevated. Both pro-inflammatory and anti-inflammatory cytokines were enhanced by implants in the acute phase, whereas only anti-inflammatory cytokines were enhanced by instruments in the subacute phase.</description><subject>Aged</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Antigens, CD - blood</subject><subject>Biological and medical sciences</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cytokines - blood</subject><subject>Decompression, Surgical</subject><subject>Emergency and intensive postoperative care (general aspects). Pathophysiology of surgery</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammation - blood</subject><subject>Inflammation - etiology</subject><subject>Intensive care medicine</subject><subject>Interleukin 1 Receptor Antagonist Protein</subject><subject>Interleukin-10 - blood</subject><subject>Interleukin-6 - blood</subject><subject>Interleukin-8 - blood</subject><subject>Lumbar Vertebrae - surgery</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Orthopedic surgery</subject><subject>Postoperative Period</subject><subject>Prostheses and Implants - adverse effects</subject><subject>Receptors, Tumor Necrosis Factor - blood</subject><subject>Receptors, Tumor Necrosis Factor, Type I</subject><subject>Receptors, Tumor Necrosis Factor, Type II</subject><subject>Sialoglycoproteins - blood</subject><subject>Spinal Diseases - blood</subject><subject>Spinal Diseases - surgery</subject><subject>Spinal Fusion</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Time Factors</subject><issn>1536-0652</issn><issn>1539-2465</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkDtPwzAQgC0EoqXwF1AW2ALnZ5wRVbykSjDASuQ4DjIkTrGdof8e0wYqhpPPp-_Ovg-hDMMVhrK4BgDCCgI5SQnIdM1TgDhAc8xpmRMm-OE2FzkITmboJIQPAFxQxo7RDBNcFJzxOXp79kNuXdupvldx8JtMuSZFtP-rehOHT-tMZp32RgUTMtVG47Owtk51qRyiH3vjoop2cFkY_bvxm1N01KoumLPpXKDXu9uX5UO-erp_XN6scs2giLlpqSRSt5QJxmvBJS7rFkBSLTkWsgaguMGYK1kayVmp0u-poIWQpEl7G7pAl7u5az98jSbEqrdBm65TzgxjqApclqSkkEC5A7UfQvCmrdbe9spvKgzVj9vq123157bauk2t59MbY92bZt84yUzAxQSooFXXeuW0DXuOSsFYWuobbAqBuw</recordid><startdate>20020801</startdate><enddate>20020801</enddate><creator>TAKAHASHI, Jun</creator><creator>EBARA, Sohei</creator><creator>KAMIMURA, Mikio</creator><creator>KINOSHITA, Tetsuya</creator><creator>MISAWA, Hiromichi</creator><creator>SHIMOGATA, Mitsuhiko</creator><creator>TOZUKA, Minoru</creator><creator>TAKAOKA, Kunio</creator><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020801</creationdate><title>Pro-inflammatory and anti-inflammatory cytokine increases after spinal instrumentation surgery</title><author>TAKAHASHI, Jun ; EBARA, Sohei ; KAMIMURA, Mikio ; KINOSHITA, Tetsuya ; MISAWA, Hiromichi ; SHIMOGATA, Mitsuhiko ; TOZUKA, Minoru ; TAKAOKA, Kunio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-ef3828cf34645b65819bf0083c85168b0031d115a89e8549a7753637682d000e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Aged</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Antigens, CD - blood</topic><topic>Biological and medical sciences</topic><topic>C-Reactive Protein - metabolism</topic><topic>Cytokines - blood</topic><topic>Decompression, Surgical</topic><topic>Emergency and intensive postoperative care (general aspects). Pathophysiology of surgery</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammation - blood</topic><topic>Inflammation - etiology</topic><topic>Intensive care medicine</topic><topic>Interleukin 1 Receptor Antagonist Protein</topic><topic>Interleukin-10 - blood</topic><topic>Interleukin-6 - blood</topic><topic>Interleukin-8 - blood</topic><topic>Lumbar Vertebrae - surgery</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Orthopedic surgery</topic><topic>Postoperative Period</topic><topic>Prostheses and Implants - adverse effects</topic><topic>Receptors, Tumor Necrosis Factor - blood</topic><topic>Receptors, Tumor Necrosis Factor, Type I</topic><topic>Receptors, Tumor Necrosis Factor, Type II</topic><topic>Sialoglycoproteins - blood</topic><topic>Spinal Diseases - blood</topic><topic>Spinal Diseases - surgery</topic><topic>Spinal Fusion</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Time Factors</topic><toplevel>online_resources</toplevel><creatorcontrib>TAKAHASHI, Jun</creatorcontrib><creatorcontrib>EBARA, Sohei</creatorcontrib><creatorcontrib>KAMIMURA, Mikio</creatorcontrib><creatorcontrib>KINOSHITA, Tetsuya</creatorcontrib><creatorcontrib>MISAWA, Hiromichi</creatorcontrib><creatorcontrib>SHIMOGATA, Mitsuhiko</creatorcontrib><creatorcontrib>TOZUKA, Minoru</creatorcontrib><creatorcontrib>TAKAOKA, Kunio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of spinal disorders & techniques</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TAKAHASHI, Jun</au><au>EBARA, Sohei</au><au>KAMIMURA, Mikio</au><au>KINOSHITA, Tetsuya</au><au>MISAWA, Hiromichi</au><au>SHIMOGATA, Mitsuhiko</au><au>TOZUKA, Minoru</au><au>TAKAOKA, Kunio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pro-inflammatory and anti-inflammatory cytokine increases after spinal instrumentation surgery</atitle><jtitle>Journal of spinal disorders & techniques</jtitle><addtitle>J Spinal Disord Tech</addtitle><date>2002-08-01</date><risdate>2002</risdate><volume>15</volume><issue>4</issue><spage>294</spage><epage>300</epage><pages>294-300</pages><issn>1536-0652</issn><eissn>1539-2465</eissn><abstract>We investigated the effects of instrumentation on postoperative inflammatory reaction and identified standard changes in serum cytokine concentrations after spinal surgery. Pro-inflammatory cytokines [interleukin (IL)-6 and IL-8] and anti-inflammatory cytokines [IL-10, IL-1 receptor antagonist (ra), and soluble tumor necrosis factor receptors (sTNF-R) I and II] were assayed in serum from seven patients with lumbar spinal posterior decompression, six with spinal decompression and posterolateral fusion without instrumentation and seven with spinal decompression and posterolateral fusion with instrumentation. All cytokines after spinal instrumentation increased significantly more than in other groups on postoperative days 0 and 1. Seven days after SI, IL-6, -8, and -10 had normalized, but IL-1ra and sTNF-RI and sTNF-RII remained elevated. Both pro-inflammatory and anti-inflammatory cytokines were enhanced by implants in the acute phase, whereas only anti-inflammatory cytokines were enhanced by instruments in the subacute phase.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams and Wilkins</pub><pmid>12177545</pmid><doi>10.1097/00024720-200208000-00006</doi><tpages>7</tpages></addata></record> |
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| subjects | Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antigens, CD - blood Biological and medical sciences C-Reactive Protein - metabolism Cytokines - blood Decompression, Surgical Emergency and intensive postoperative care (general aspects). Pathophysiology of surgery Female Humans Inflammation - blood Inflammation - etiology Intensive care medicine Interleukin 1 Receptor Antagonist Protein Interleukin-10 - blood Interleukin-6 - blood Interleukin-8 - blood Lumbar Vertebrae - surgery Male Medical sciences Middle Aged Orthopedic surgery Postoperative Period Prostheses and Implants - adverse effects Receptors, Tumor Necrosis Factor - blood Receptors, Tumor Necrosis Factor, Type I Receptors, Tumor Necrosis Factor, Type II Sialoglycoproteins - blood Spinal Diseases - blood Spinal Diseases - surgery Spinal Fusion Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Time Factors |
| title | Pro-inflammatory and anti-inflammatory cytokine increases after spinal instrumentation surgery |
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