Body Weight and Food Intake Profiles Are Modulated by Sex Hormones and Tamoxifen in Chronically Hypertensive Rats
Sex hormones and the selective estrogen receptor modulator tamoxifen affect food consumption and body weight in normotensive rats. This study investigated the effects of hormone manipulation and tamoxifen on weight gain and food intake in the presence of chronic systemic hypertension. Male and femal...
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| Veröffentlicht in: | The Journal of nutrition 2002-08, Vol.132 (8), p.2246-2250 |
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| description | Sex hormones and the selective estrogen receptor modulator tamoxifen affect food consumption and body weight in normotensive rats. This study investigated the effects of hormone manipulation and tamoxifen on weight gain and food intake in the presence of chronic systemic hypertension. Male and female spontaneously hypertensive rats (SHR) were either neutered or sham operated before puberty, and subgroups of neutered females received either estrogen replacement therapy (ERT) or tamoxifen at the age of 12 wk. Weekly body weight and food consumption were assessed, and food consumption was normalized to metabolic weight (g body2/3). Neutering reduced weight gain in males (P = 0.0001), but increased it in females (P < 0.0001). Both ERT and tamoxifen treatment prevented this increase in weight, with body weight dropping to levels of sham-operated rats for ERT, whereas rats given tamoxifen maintained greater body weights than sham-operated rats (P < 0.0001). This contrasts with previous work in normotensive females in which sham-operated and tamoxifen-treated females did not differ. Neutering reduced normalized food consumption relative to sham-operated rats in both males and females (P < 0.05). Although ERT returned it to normalized intakes of sham-operated rats, tamoxifen reduced normalized food consumption relative to that of both sham-operated and ERT groups. In hypertensive rats, body weight is modulated by sex hormones in both males and females, but in opposite directions. Both estrogen and tamoxifen exert immediate effects in females. Interestingly, the effect of tamoxifen on body weight appears to be greater in hypertensive than in normotensive rats. |
| doi_str_mv | 10.1093/jn/132.8.2246 |
| format | Article |
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Jack ; Belanger, Michael P. ; Wittnich, Carin</creator><creatorcontrib>Wallen, W. Jack ; Belanger, Michael P. ; Wittnich, Carin</creatorcontrib><description>Sex hormones and the selective estrogen receptor modulator tamoxifen affect food consumption and body weight in normotensive rats. This study investigated the effects of hormone manipulation and tamoxifen on weight gain and food intake in the presence of chronic systemic hypertension. Male and female spontaneously hypertensive rats (SHR) were either neutered or sham operated before puberty, and subgroups of neutered females received either estrogen replacement therapy (ERT) or tamoxifen at the age of 12 wk. Weekly body weight and food consumption were assessed, and food consumption was normalized to metabolic weight (g body2/3). Neutering reduced weight gain in males (P = 0.0001), but increased it in females (P < 0.0001). Both ERT and tamoxifen treatment prevented this increase in weight, with body weight dropping to levels of sham-operated rats for ERT, whereas rats given tamoxifen maintained greater body weights than sham-operated rats (P < 0.0001). This contrasts with previous work in normotensive females in which sham-operated and tamoxifen-treated females did not differ. Neutering reduced normalized food consumption relative to sham-operated rats in both males and females (P < 0.05). Although ERT returned it to normalized intakes of sham-operated rats, tamoxifen reduced normalized food consumption relative to that of both sham-operated and ERT groups. In hypertensive rats, body weight is modulated by sex hormones in both males and females, but in opposite directions. Both estrogen and tamoxifen exert immediate effects in females. 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Drug treatments ; Rats ; Rats, Inbred SHR ; selective estrogen receptor modulator ; sex hormones ; spontaneously hypertensive rats ; tamoxifen ; Tamoxifen - pharmacology ; weight gain</subject><ispartof>The Journal of nutrition, 2002-08, Vol.132 (8), p.2246-2250</ispartof><rights>2002 American Society for Nutrition.</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-3fe6d475911bd09f51ae31607c68a720b582013dfc6ca63ff06a22fc3536e2ed3</citedby><cites>FETCH-LOGICAL-c430t-3fe6d475911bd09f51ae31607c68a720b582013dfc6ca63ff06a22fc3536e2ed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13844145$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12163670$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wallen, W. Jack</creatorcontrib><creatorcontrib>Belanger, Michael P.</creatorcontrib><creatorcontrib>Wittnich, Carin</creatorcontrib><title>Body Weight and Food Intake Profiles Are Modulated by Sex Hormones and Tamoxifen in Chronically Hypertensive Rats</title><title>The Journal of nutrition</title><addtitle>J Nutr</addtitle><description>Sex hormones and the selective estrogen receptor modulator tamoxifen affect food consumption and body weight in normotensive rats. This study investigated the effects of hormone manipulation and tamoxifen on weight gain and food intake in the presence of chronic systemic hypertension. Male and female spontaneously hypertensive rats (SHR) were either neutered or sham operated before puberty, and subgroups of neutered females received either estrogen replacement therapy (ERT) or tamoxifen at the age of 12 wk. Weekly body weight and food consumption were assessed, and food consumption was normalized to metabolic weight (g body2/3). Neutering reduced weight gain in males (P = 0.0001), but increased it in females (P < 0.0001). Both ERT and tamoxifen treatment prevented this increase in weight, with body weight dropping to levels of sham-operated rats for ERT, whereas rats given tamoxifen maintained greater body weights than sham-operated rats (P < 0.0001). This contrasts with previous work in normotensive females in which sham-operated and tamoxifen-treated females did not differ. Neutering reduced normalized food consumption relative to sham-operated rats in both males and females (P < 0.05). Although ERT returned it to normalized intakes of sham-operated rats, tamoxifen reduced normalized food consumption relative to that of both sham-operated and ERT groups. In hypertensive rats, body weight is modulated by sex hormones in both males and females, but in opposite directions. Both estrogen and tamoxifen exert immediate effects in females. Interestingly, the effect of tamoxifen on body weight appears to be greater in hypertensive than in normotensive rats.</description><subject>17β-estradiol</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Weight - physiology</subject><subject>Energy Intake - physiology</subject><subject>estrogen replacement therapy</subject><subject>Female</subject><subject>females</subject><subject>food intake</subject><subject>gender</subject><subject>Gonadal Steroid Hormones - physiology</subject><subject>Hormones. Endocrine system</subject><subject>Hypertension - genetics</subject><subject>Hypertension - physiopathology</subject><subject>Male</subject><subject>males</subject><subject>Medical sciences</subject><subject>Orchiectomy</subject><subject>Ovariectomy</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Inbred SHR</subject><subject>selective estrogen receptor modulator</subject><subject>sex hormones</subject><subject>spontaneously hypertensive rats</subject><subject>tamoxifen</subject><subject>Tamoxifen - pharmacology</subject><subject>weight gain</subject><issn>0022-3166</issn><issn>1541-6100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10UFvFCEUwHFiNHatHr0qF73N9gEzzMyx3Vi3SY3GtvFIWHi0rLOwhdmm8-1ls5v05IkDP17gDyEfGcwZ9OJsHc6Y4PNuznktX5EZa2pWSQbwmswAOK8Ek_KEvMt5DQCs7ru35IRxJoVsYUYeL6Kd6B_09w8j1cHSyxgtvQqj_ov0V4rOD5jpeUL6I9rdoEe0dDXRG3ymy5g2MZTd_bFbvYnP3mGgPtDFQ4rBGz0ME11OW0wjhuyfkP7WY35P3jg9ZPxwXE_J3eW328Wyuv75_Wpxfl2ZWsBYCYfS1m3TM7ay0LuGaSxPgdbITrccVk3HgQnrjDRaCudAas6dEY2QyNGKU_L1MHeb4uMO86g2PhscBh0w7rJqWd9D10KB1QGaFHNO6NQ2-Y1Ok2Kg9o3VOqjSWHVq37j4T8fBu9UG7Ys-Ri3gyxHoXCK4pIPx-cWJrq5Z3RT3-eCcjkrfp2Lubsqj6vJRsoi2iPYgsIR68phUNh6DQesTmlHZ6P9zyX_RSqAE</recordid><startdate>20020801</startdate><enddate>20020801</enddate><creator>Wallen, W. Jack</creator><creator>Belanger, Michael P.</creator><creator>Wittnich, Carin</creator><general>Elsevier Inc</general><general>American Society for Nutritional Sciences</general><scope>6I.</scope><scope>AAFTH</scope><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020801</creationdate><title>Body Weight and Food Intake Profiles Are Modulated by Sex Hormones and Tamoxifen in Chronically Hypertensive Rats</title><author>Wallen, W. Jack ; Belanger, Michael P. ; Wittnich, Carin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-3fe6d475911bd09f51ae31607c68a720b582013dfc6ca63ff06a22fc3536e2ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>17β-estradiol</topic><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body Weight - physiology</topic><topic>Energy Intake - physiology</topic><topic>estrogen replacement therapy</topic><topic>Female</topic><topic>females</topic><topic>food intake</topic><topic>gender</topic><topic>Gonadal Steroid Hormones - physiology</topic><topic>Hormones. Endocrine system</topic><topic>Hypertension - genetics</topic><topic>Hypertension - physiopathology</topic><topic>Male</topic><topic>males</topic><topic>Medical sciences</topic><topic>Orchiectomy</topic><topic>Ovariectomy</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Inbred SHR</topic><topic>selective estrogen receptor modulator</topic><topic>sex hormones</topic><topic>spontaneously hypertensive rats</topic><topic>tamoxifen</topic><topic>Tamoxifen - pharmacology</topic><topic>weight gain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wallen, W. Jack</creatorcontrib><creatorcontrib>Belanger, Michael P.</creatorcontrib><creatorcontrib>Wittnich, Carin</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wallen, W. Jack</au><au>Belanger, Michael P.</au><au>Wittnich, Carin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Body Weight and Food Intake Profiles Are Modulated by Sex Hormones and Tamoxifen in Chronically Hypertensive Rats</atitle><jtitle>The Journal of nutrition</jtitle><addtitle>J Nutr</addtitle><date>2002-08-01</date><risdate>2002</risdate><volume>132</volume><issue>8</issue><spage>2246</spage><epage>2250</epage><pages>2246-2250</pages><issn>0022-3166</issn><eissn>1541-6100</eissn><coden>JONUAI</coden><abstract>Sex hormones and the selective estrogen receptor modulator tamoxifen affect food consumption and body weight in normotensive rats. This study investigated the effects of hormone manipulation and tamoxifen on weight gain and food intake in the presence of chronic systemic hypertension. Male and female spontaneously hypertensive rats (SHR) were either neutered or sham operated before puberty, and subgroups of neutered females received either estrogen replacement therapy (ERT) or tamoxifen at the age of 12 wk. Weekly body weight and food consumption were assessed, and food consumption was normalized to metabolic weight (g body2/3). Neutering reduced weight gain in males (P = 0.0001), but increased it in females (P < 0.0001). Both ERT and tamoxifen treatment prevented this increase in weight, with body weight dropping to levels of sham-operated rats for ERT, whereas rats given tamoxifen maintained greater body weights than sham-operated rats (P < 0.0001). This contrasts with previous work in normotensive females in which sham-operated and tamoxifen-treated females did not differ. Neutering reduced normalized food consumption relative to sham-operated rats in both males and females (P < 0.05). Although ERT returned it to normalized intakes of sham-operated rats, tamoxifen reduced normalized food consumption relative to that of both sham-operated and ERT groups. In hypertensive rats, body weight is modulated by sex hormones in both males and females, but in opposite directions. Both estrogen and tamoxifen exert immediate effects in females. Interestingly, the effect of tamoxifen on body weight appears to be greater in hypertensive than in normotensive rats.</abstract><cop>Bethesda, MD</cop><pub>Elsevier Inc</pub><pmid>12163670</pmid><doi>10.1093/jn/132.8.2246</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 17β-estradiol Analysis of Variance Animals Biological and medical sciences Body Weight - physiology Energy Intake - physiology estrogen replacement therapy Female females food intake gender Gonadal Steroid Hormones - physiology Hormones. Endocrine system Hypertension - genetics Hypertension - physiopathology Male males Medical sciences Orchiectomy Ovariectomy Pharmacology. Drug treatments Rats Rats, Inbred SHR selective estrogen receptor modulator sex hormones spontaneously hypertensive rats tamoxifen Tamoxifen - pharmacology weight gain |
| title | Body Weight and Food Intake Profiles Are Modulated by Sex Hormones and Tamoxifen in Chronically Hypertensive Rats |
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