Age-Related Analysis of Inhibin A, Inhibin B, and Activin A Relative to the Intercycle Monotropic Follicle-Stimulating Hormone Rise in Normal Ovulatory Women
Previous studies have reported that the monotropic rise in FSH in older women is associated with decreased inhibin B and/or A levels and increased levels of activin A. Whereas most investigators have found decreased follicular-phase inhibin B, the roles of inhibin A and activin A as modulators of th...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2004-06, Vol.89 (6), p.2977-2981 |
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| container_title | The journal of clinical endocrinology and metabolism |
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| creator | Klein, Nancy A. Houmard, Brenda S. Hansen, Karl R. Woodruff, Teresa K. Sluss, Patrick M. Bremner, William J. Soules, Michael R. |
| description | Previous studies have reported that the monotropic rise in FSH in older women is associated with decreased inhibin B and/or A levels and increased levels of activin A. Whereas most investigators have found decreased follicular-phase inhibin B, the roles of inhibin A and activin A as modulators of the FSH rise are unclear. The objectives of this study were to determine whether deficiencies in circulating levels of inhibin A, inhibin B, and/or activin A exist during the intercycle interval in ovulatory older (age, 40–45 yr; n = 16), compared with younger women (age, 20–25 yr; n = 13). Blood samples were obtained daily throughout one menstrual cycle and the follicular phase of the subsequent cycle and were analyzed for LH, FSH, estradiol, inhibin A and B, and activin A. Despite significant FSH elevation, no deficiencies in inhibin A, activin A, or estradiol were detected in older subjects. In fact, inhibin A was significantly higher in older participants during the intercycle phase (P = 0.01), whereas inhibin B was significantly lower. Thus, the monotropic rise in FSH does not appear to result from changes in inhibin A or activin A, supporting the concept that inhibin B plays a critical role in mediating the FSH rise in older women. |
| doi_str_mv | 10.1210/jc.2003-031515 |
| format | Article |
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Whereas most investigators have found decreased follicular-phase inhibin B, the roles of inhibin A and activin A as modulators of the FSH rise are unclear. The objectives of this study were to determine whether deficiencies in circulating levels of inhibin A, inhibin B, and/or activin A exist during the intercycle interval in ovulatory older (age, 40–45 yr; n = 16), compared with younger women (age, 20–25 yr; n = 13). Blood samples were obtained daily throughout one menstrual cycle and the follicular phase of the subsequent cycle and were analyzed for LH, FSH, estradiol, inhibin A and B, and activin A. Despite significant FSH elevation, no deficiencies in inhibin A, activin A, or estradiol were detected in older subjects. In fact, inhibin A was significantly higher in older participants during the intercycle phase (P = 0.01), whereas inhibin B was significantly lower. Thus, the monotropic rise in FSH does not appear to result from changes in inhibin A or activin A, supporting the concept that inhibin B plays a critical role in mediating the FSH rise in older women.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.2003-031515</identifier><identifier>PMID: 15181087</identifier><identifier>CODEN: JCEMAZ</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Activins - blood ; Adult ; Aging - metabolism ; Biological and medical sciences ; Biomarkers ; Endocrinopathies ; Estradiol - blood ; Feeding. Feeding behavior ; Female ; Follicle Stimulating Hormone - blood ; Follicular Phase - metabolism ; Fundamental and applied biological sciences. Psychology ; Humans ; Inhibin-beta Subunits - blood ; Inhibins - blood ; Luteinizing Hormone - blood ; Medical sciences ; Middle Aged ; Progesterone - blood ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vertebrates: endocrinology</subject><ispartof>The journal of clinical endocrinology and metabolism, 2004-06, Vol.89 (6), p.2977-2981</ispartof><rights>Copyright © Oxford University Press 2015</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4521-12ae31612fc2e713a2983c8882642c8ad439bff46925c93922a1cdc8d71655a13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15842191$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15181087$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Klein, Nancy A.</creatorcontrib><creatorcontrib>Houmard, Brenda S.</creatorcontrib><creatorcontrib>Hansen, Karl R.</creatorcontrib><creatorcontrib>Woodruff, Teresa K.</creatorcontrib><creatorcontrib>Sluss, Patrick M.</creatorcontrib><creatorcontrib>Bremner, William J.</creatorcontrib><creatorcontrib>Soules, Michael R.</creatorcontrib><title>Age-Related Analysis of Inhibin A, Inhibin B, and Activin A Relative to the Intercycle Monotropic Follicle-Stimulating Hormone Rise in Normal Ovulatory Women</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Previous studies have reported that the monotropic rise in FSH in older women is associated with decreased inhibin B and/or A levels and increased levels of activin A. Whereas most investigators have found decreased follicular-phase inhibin B, the roles of inhibin A and activin A as modulators of the FSH rise are unclear. The objectives of this study were to determine whether deficiencies in circulating levels of inhibin A, inhibin B, and/or activin A exist during the intercycle interval in ovulatory older (age, 40–45 yr; n = 16), compared with younger women (age, 20–25 yr; n = 13). Blood samples were obtained daily throughout one menstrual cycle and the follicular phase of the subsequent cycle and were analyzed for LH, FSH, estradiol, inhibin A and B, and activin A. Despite significant FSH elevation, no deficiencies in inhibin A, activin A, or estradiol were detected in older subjects. In fact, inhibin A was significantly higher in older participants during the intercycle phase (P = 0.01), whereas inhibin B was significantly lower. Thus, the monotropic rise in FSH does not appear to result from changes in inhibin A or activin A, supporting the concept that inhibin B plays a critical role in mediating the FSH rise in older women.</description><subject>Activins - blood</subject><subject>Adult</subject><subject>Aging - metabolism</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Endocrinopathies</subject><subject>Estradiol - blood</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Follicular Phase - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Inhibin-beta Subunits - blood</subject><subject>Inhibins - blood</subject><subject>Luteinizing Hormone - blood</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Progesterone - blood</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vertebrates: endocrinology</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUFvFCEUx4nR2LV69Wi46KmzAsPMwHHbWNuk2qRq9EZY5k2XlYEVZrbZD-N3lXE26kUSAg9-_8fj_RF6ScmSMkrebs2SEVIWpKQVrR6hBZW8Khoqm8doQQijhWzYtxP0LKUtIZTzqnyKTjIrKBHNAv1c3UNxB04P0OKV1-6QbMKhw9d-Y9fW49XZn-35GdY-U2aw--kG_9bZPeAh4GEDGRwgmoNxgD8EH4YYdtbgy-CczWfFp8H246Tw9_gqxD54wHc2Ac7JPuZYO3y7n4AQD_hr6ME_R0867RK8OK6n6Mvlu88XV8XN7fvri9VNYXiVv0iZhpLWlHWGQUNLzaQojRCC1ZwZoVteynXX8VqyyshSMqapaY1oG1pXlablKXoz593F8GOENKjeJgPOaQ9hTCr3U0gmeAaXM2hiSClCp3bR9joeFCVqMkRtjZoMUbMhWfDqmHlc99D-xY8OZOD1EdDJaNdF7Y1N_3CCMyqnEvnMPQSXu5y-u_EBotqAdsNGkTx43Ygiv81JnaMiz2aSVbMMfBtMtB52EVJS2zDG7Hb6X92_ACmItC8</recordid><startdate>200406</startdate><enddate>200406</enddate><creator>Klein, Nancy A.</creator><creator>Houmard, Brenda S.</creator><creator>Hansen, Karl R.</creator><creator>Woodruff, Teresa K.</creator><creator>Sluss, Patrick M.</creator><creator>Bremner, William J.</creator><creator>Soules, Michael R.</creator><general>Endocrine Society</general><general>Copyright Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200406</creationdate><title>Age-Related Analysis of Inhibin A, Inhibin B, and Activin A Relative to the Intercycle Monotropic Follicle-Stimulating Hormone Rise in Normal Ovulatory Women</title><author>Klein, Nancy A. ; Houmard, Brenda S. ; Hansen, Karl R. ; Woodruff, Teresa K. ; Sluss, Patrick M. ; Bremner, William J. ; Soules, Michael R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4521-12ae31612fc2e713a2983c8882642c8ad439bff46925c93922a1cdc8d71655a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Activins - blood</topic><topic>Adult</topic><topic>Aging - metabolism</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Endocrinopathies</topic><topic>Estradiol - blood</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>Follicular Phase - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Inhibin-beta Subunits - blood</topic><topic>Inhibins - blood</topic><topic>Luteinizing Hormone - blood</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Progesterone - blood</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Klein, Nancy A.</creatorcontrib><creatorcontrib>Houmard, Brenda S.</creatorcontrib><creatorcontrib>Hansen, Karl R.</creatorcontrib><creatorcontrib>Woodruff, Teresa K.</creatorcontrib><creatorcontrib>Sluss, Patrick M.</creatorcontrib><creatorcontrib>Bremner, William J.</creatorcontrib><creatorcontrib>Soules, Michael R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Klein, Nancy A.</au><au>Houmard, Brenda S.</au><au>Hansen, Karl R.</au><au>Woodruff, Teresa K.</au><au>Sluss, Patrick M.</au><au>Bremner, William J.</au><au>Soules, Michael R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age-Related Analysis of Inhibin A, Inhibin B, and Activin A Relative to the Intercycle Monotropic Follicle-Stimulating Hormone Rise in Normal Ovulatory Women</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2004-06</date><risdate>2004</risdate><volume>89</volume><issue>6</issue><spage>2977</spage><epage>2981</epage><pages>2977-2981</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><coden>JCEMAZ</coden><abstract>Previous studies have reported that the monotropic rise in FSH in older women is associated with decreased inhibin B and/or A levels and increased levels of activin A. Whereas most investigators have found decreased follicular-phase inhibin B, the roles of inhibin A and activin A as modulators of the FSH rise are unclear. The objectives of this study were to determine whether deficiencies in circulating levels of inhibin A, inhibin B, and/or activin A exist during the intercycle interval in ovulatory older (age, 40–45 yr; n = 16), compared with younger women (age, 20–25 yr; n = 13). Blood samples were obtained daily throughout one menstrual cycle and the follicular phase of the subsequent cycle and were analyzed for LH, FSH, estradiol, inhibin A and B, and activin A. Despite significant FSH elevation, no deficiencies in inhibin A, activin A, or estradiol were detected in older subjects. In fact, inhibin A was significantly higher in older participants during the intercycle phase (P = 0.01), whereas inhibin B was significantly lower. Thus, the monotropic rise in FSH does not appear to result from changes in inhibin A or activin A, supporting the concept that inhibin B plays a critical role in mediating the FSH rise in older women.</abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>15181087</pmid><doi>10.1210/jc.2003-031515</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Activins - blood Adult Aging - metabolism Biological and medical sciences Biomarkers Endocrinopathies Estradiol - blood Feeding. Feeding behavior Female Follicle Stimulating Hormone - blood Follicular Phase - metabolism Fundamental and applied biological sciences. Psychology Humans Inhibin-beta Subunits - blood Inhibins - blood Luteinizing Hormone - blood Medical sciences Middle Aged Progesterone - blood Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology |
| title | Age-Related Analysis of Inhibin A, Inhibin B, and Activin A Relative to the Intercycle Monotropic Follicle-Stimulating Hormone Rise in Normal Ovulatory Women |
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