p53 activation results in rapid dephosphorylation of the eIF4E-binding protein 4E-BP1, inhibition of ribosomal protein S6 kinase and inhibition of translation initiation

p53 is an important regulator of cell cycle progression and apoptosis, and inactivation of p53 is associated with tumorigenesis. Although p53 exerts many of its effects through regulation of transcription, this protein is also found in association with ribosomes and several mRNAs have been identifie...

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Veröffentlicht in:	Oncogene 2002-08, Vol.21 (34), p.5325-5334
Hauptverfasser:	HORTON, Lynn E, BUSHELL, Martin, BARTH-BAUS, Diane, TILLERAY, Vivienne J, CLEMENS, Michael J, HENSOLD, Jack O
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Amino Acids - metabolism Analysis Apoptosis Biological and medical sciences Biotechnology Carrier Proteins - genetics Carrier Proteins - metabolism Cell cycle Cell growth Cell Line Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Chemical properties Cyclin-Dependent Kinase Inhibitor p21 Cyclins - metabolism Dephosphorylation DNA-Binding Proteins - metabolism Erythrocytes - cytology Erythrocytes - metabolism Eukaryotic Initiation Factor-4E Fundamental and applied biological sciences. Psychology Gene Expression Regulation Gene regulation Gene therapy Health. Pharmaceutical industry Humans Immunology Industrial applications and implications. Economical aspects Initiation factor eIF-4E Kinases Leukemia, Erythroblastic, Acute - metabolism Messenger RNA Molecular and cellular biology p53 Protein Peptide Initiation Factors - genetics Peptide Initiation Factors - metabolism Phosphoproteins - genetics Phosphoproteins - metabolism Phosphorylation Polypeptides Protein binding Protein Biosynthesis Protein Kinases Protein synthesis Protein-Serine-Threonine Kinases Proteins Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt Repressor Proteins - genetics Repressor Proteins - metabolism Ribonucleic acid Ribosomal protein S6 Ribosomal protein S6 kinase Ribosomal Protein S6 Kinases - metabolism Ribosomal proteins Ribosomes Ribosomes - metabolism RNA Temperature TOR Serine-Threonine Kinases Transcription Transcription Factors - metabolism Transfer RNA Translation initiation Tumor proteins Tumor Suppressor Protein p53 - metabolism Tumorigenesis
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