Pharmacokinetics of plasma enfuvirtide after subcutaneous administration to patients with human immunodeficiency virus: Inverse Gaussian density absorption and 2-compartment disposition

Enfuvirtide (T-20) is the first of a novel class of human immunodeficiency virus (HIV) drugs that block gp41-mediated viral fusion to host cells. The objectives of this study were to develop a structural pharmacokinetic model that would adequately characterize the absorption and disposition of enfuv...

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Veröffentlicht in:Clinical pharmacology and therapeutics 2002-07, Vol.72 (1), p.10-19
Hauptverfasser: XIAOPING ZHANG, NIEFORTH, Keith, LANG, Jean-Marie, ROUZIER-PANIS, Regine, REYNES, Jacques, DORR, Albert, KOLIS, Stanley, STILES, Mark R, KINCHELOW, Tosca, PATEL, Indravadan H
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Sprache:eng
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