Computational identification of putative programmed translational frameshift sites

In an effort to identify potential programmed frameshift sites by statistical analysis, we explore the hypothesis that selective pressure would have rendered such sites underabundant and underrepresented in protein-coding sequences. We developed a computer program to compare the frequencies of k-len...

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Veröffentlicht in:	Bioinformatics (Oxford, England) England), 2002-08, Vol.18 (8), p.1046-1053
Hauptverfasser:	SHAH, Atul A, GIDDINGS, Michael C, PARVAZ, Jasmin B, GESTELAND, Raymond F, ATKINS, John F, IVANOV, Ivaylo P
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Analysis of the immune response. Humoral and cellular immunity Antigenic determinants, haptens, artificial antigens Antigens Base Composition Base Sequence Biological and medical sciences Databases, Genetic DNA - chemistry DNA - genetics Frameshift Mutation - genetics Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Expression Regulation General aspects Immunobiology Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects) Models, Genetic Models, Statistical Molecular immunology Molecular Sequence Data Organs and cells involved in the immune response Protein Biosynthesis - genetics Reproducibility of Results Saccharomyces - genetics Sensitivity and Specificity Sequence Analysis, DNA - methods Sequence Analysis, DNA - statistics & numerical data Software
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