The Clonal Nature of Pityriasis Lichenoides
BACKGROUND Pityriasis lichenoides et varioliformis acuta (PLEVA) and pityriasis lichenoides chronica (PLC) are benign lymphocytic infiltrates of the skin that classically present as either a recurrent papulonecrotic eruption (PLEVA) or a persistent, scaling, papular eruption (PLC). Observations of b...
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| Veröffentlicht in: | Archives of dermatology (1960) 2002-08, Vol.138 (8), p.1063-1067 |
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| creator | Weinberg, Jeffrey M Kristal, Leonard Chooback, Lillian Honig, Paul J Kramer, E. Michael Lessin, Stuart R |
| description | BACKGROUND Pityriasis lichenoides et varioliformis acuta (PLEVA) and pityriasis
lichenoides chronica (PLC) are benign lymphocytic infiltrates of the skin
that classically present as either a recurrent papulonecrotic eruption (PLEVA)
or a persistent, scaling, papular eruption (PLC). Observations of both types
of lesions present on individual patients have led to speculation that both
entities are related. Previous studies evaluating the DNA of biopsy specimens
from patients with PLEVA and PLC revealed clonal T-cell receptor β gene
rearrangements. OBJECTIVE To analyze and compare the T-cell populations between lesions of PLEVA
and PLC. DESIGN Retrospective and prospective analysis of patient tissue samples, classified
by histologic analysis. Extracted DNA from 13 skin biopsy specimens with the
diagnosis of PLC and 14 skin biopsy specimens with the diagnosis of PLEVA
was analyzed by polymerase chain reaction/denaturing gradient gel electrophoresis
(PCR/DGGE). SETTING Molecular diagnostic laboratory at an academic medical center. PATIENTS Twenty-seven tissue samples were obtained from patients with a histologic
diagnosis of PLEVA or PLC. These samples were analyzed by PCR/DGGE. MAIN OUTCOME MEASURE The presence or absence of T-cell receptor gene rearrangements on PCR/DGGE
analysis corresponding to a clonal population of T cells. RESULTS Of 14 PLEVA specimens, 8 (57%) demonstrated monoclonal T-cell receptor
gene rearrangements; 1 (8%) of 13 PLC specimens showed a gene rearrangement
(P = .008, Fisher exact test). CONCLUSIONS Our results demonstrate the polyclonal nature of the lymphocytic infiltrate
found in almost all of the PLC specimens, which contrasts with the monoclonal
nature found in most of the PLEVA specimens. These differences may represent
different stages of the clinical evolution of a single entity that results
from varying host immune responses to pathogenic factors. Specifically, we
propose that PLEVA is a benign clonal T-cell disorder in which the clone arises
from a subset of T cells in lesions of PLC. The host immune response to this
clone determines the clinical and histologic findings in PLEVA.Arch Dermatol. 2002;138:1063-1067--> |
| doi_str_mv | 10.1001/archderm.138.8.1063 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71987930</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><ama_id>478931</ama_id><sourcerecordid>153644851</sourcerecordid><originalsourceid>FETCH-LOGICAL-a376t-fdf1371c56573eb7f3c30eb06fb6358e93108a15876f038946009296e006fa433</originalsourceid><addsrcrecordid>eNpdkF1LwzAUhoMobk5_gAhSBL2RzqSnzcelDL9gqBcTvAtpmrCMdtWkvdi_N2PVgVcHznneF86D0AXBU4IxuVNeLyvjmykBPuVxR-EAjUkBPAVaZIdojDGGVHD2OUInIaxiKOM8O0YjkhGaszwfo9vF0iSzul2rOnlVXe9N0trk3XUb71RwIZk7vTTr1lUmnKIjq-pgzoY5QR-PD4vZczp_e3qZ3c9TBYx2qa0sAUZ0QQsGpmQWNGBTYmpLCgU3AgjmihScUYuBi5xiLDJBDY6IygEm6GbX--Xb796ETjYuaFPXam3aPkhG4k8CcASv_oGrtvfxlSAzAAIZwyJCsIO0b0Pwxsov7xrlN5JguRUpf0XKKFJyuRUZU5dDdV82ptpnBnMRuB4AFbSqrVdr7cKeA54LxnjkznecatTfNWc8WoAfXBCCrg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>233132709</pqid></control><display><type>article</type><title>The Clonal Nature of Pityriasis Lichenoides</title><source>MEDLINE</source><source>American Medical Association Journals</source><creator>Weinberg, Jeffrey M ; Kristal, Leonard ; Chooback, Lillian ; Honig, Paul J ; Kramer, E. Michael ; Lessin, Stuart R</creator><creatorcontrib>Weinberg, Jeffrey M ; Kristal, Leonard ; Chooback, Lillian ; Honig, Paul J ; Kramer, E. Michael ; Lessin, Stuart R</creatorcontrib><description>BACKGROUND Pityriasis lichenoides et varioliformis acuta (PLEVA) and pityriasis
lichenoides chronica (PLC) are benign lymphocytic infiltrates of the skin
that classically present as either a recurrent papulonecrotic eruption (PLEVA)
or a persistent, scaling, papular eruption (PLC). Observations of both types
of lesions present on individual patients have led to speculation that both
entities are related. Previous studies evaluating the DNA of biopsy specimens
from patients with PLEVA and PLC revealed clonal T-cell receptor β gene
rearrangements. OBJECTIVE To analyze and compare the T-cell populations between lesions of PLEVA
and PLC. DESIGN Retrospective and prospective analysis of patient tissue samples, classified
by histologic analysis. Extracted DNA from 13 skin biopsy specimens with the
diagnosis of PLC and 14 skin biopsy specimens with the diagnosis of PLEVA
was analyzed by polymerase chain reaction/denaturing gradient gel electrophoresis
(PCR/DGGE). SETTING Molecular diagnostic laboratory at an academic medical center. PATIENTS Twenty-seven tissue samples were obtained from patients with a histologic
diagnosis of PLEVA or PLC. These samples were analyzed by PCR/DGGE. MAIN OUTCOME MEASURE The presence or absence of T-cell receptor gene rearrangements on PCR/DGGE
analysis corresponding to a clonal population of T cells. RESULTS Of 14 PLEVA specimens, 8 (57%) demonstrated monoclonal T-cell receptor
gene rearrangements; 1 (8%) of 13 PLC specimens showed a gene rearrangement
(P = .008, Fisher exact test). CONCLUSIONS Our results demonstrate the polyclonal nature of the lymphocytic infiltrate
found in almost all of the PLC specimens, which contrasts with the monoclonal
nature found in most of the PLEVA specimens. These differences may represent
different stages of the clinical evolution of a single entity that results
from varying host immune responses to pathogenic factors. Specifically, we
propose that PLEVA is a benign clonal T-cell disorder in which the clone arises
from a subset of T cells in lesions of PLC. The host immune response to this
clone determines the clinical and histologic findings in PLEVA.Arch Dermatol. 2002;138:1063-1067--></description><identifier>ISSN: 0003-987X</identifier><identifier>ISSN: 2168-6068</identifier><identifier>EISSN: 1538-3652</identifier><identifier>EISSN: 2168-6084</identifier><identifier>DOI: 10.1001/archderm.138.8.1063</identifier><identifier>PMID: 12164744</identifier><identifier>CODEN: ARDEAC</identifier><language>eng</language><publisher>Chicago, IL: American Medical Association</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Child ; Child, Preschool ; Clonal Anergy - genetics ; Dermatology ; Female ; Gene Order - genetics ; Genes, T-Cell Receptor - genetics ; Humans ; Infant ; Male ; Medical sciences ; Middle Aged ; Pityriasis Lichenoides - complications ; Pityriasis Lichenoides - genetics ; Pityriasis Lichenoides - pathology ; Prospective Studies ; Retrospective Studies ; Skin involvement in other diseases. Miscellaneous. General aspects</subject><ispartof>Archives of dermatology (1960), 2002-08, Vol.138 (8), p.1063-1067</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright American Medical Association Aug 2002</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a376t-fdf1371c56573eb7f3c30eb06fb6358e93108a15876f038946009296e006fa433</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://jamanetwork.com/journals/jamadermatology/articlepdf/10.1001/archderm.138.8.1063$$EPDF$$P50$$Gama$$H</linktopdf><linktohtml>$$Uhttps://jamanetwork.com/journals/jamadermatology/fullarticle/10.1001/archderm.138.8.1063$$EHTML$$P50$$Gama$$H</linktohtml><link.rule.ids>64,314,776,780,3327,27901,27902,76231,76234</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13849778$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12164744$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Weinberg, Jeffrey M</creatorcontrib><creatorcontrib>Kristal, Leonard</creatorcontrib><creatorcontrib>Chooback, Lillian</creatorcontrib><creatorcontrib>Honig, Paul J</creatorcontrib><creatorcontrib>Kramer, E. Michael</creatorcontrib><creatorcontrib>Lessin, Stuart R</creatorcontrib><title>The Clonal Nature of Pityriasis Lichenoides</title><title>Archives of dermatology (1960)</title><addtitle>Arch Dermatol</addtitle><description>BACKGROUND Pityriasis lichenoides et varioliformis acuta (PLEVA) and pityriasis
lichenoides chronica (PLC) are benign lymphocytic infiltrates of the skin
that classically present as either a recurrent papulonecrotic eruption (PLEVA)
or a persistent, scaling, papular eruption (PLC). Observations of both types
of lesions present on individual patients have led to speculation that both
entities are related. Previous studies evaluating the DNA of biopsy specimens
from patients with PLEVA and PLC revealed clonal T-cell receptor β gene
rearrangements. OBJECTIVE To analyze and compare the T-cell populations between lesions of PLEVA
and PLC. DESIGN Retrospective and prospective analysis of patient tissue samples, classified
by histologic analysis. Extracted DNA from 13 skin biopsy specimens with the
diagnosis of PLC and 14 skin biopsy specimens with the diagnosis of PLEVA
was analyzed by polymerase chain reaction/denaturing gradient gel electrophoresis
(PCR/DGGE). SETTING Molecular diagnostic laboratory at an academic medical center. PATIENTS Twenty-seven tissue samples were obtained from patients with a histologic
diagnosis of PLEVA or PLC. These samples were analyzed by PCR/DGGE. MAIN OUTCOME MEASURE The presence or absence of T-cell receptor gene rearrangements on PCR/DGGE
analysis corresponding to a clonal population of T cells. RESULTS Of 14 PLEVA specimens, 8 (57%) demonstrated monoclonal T-cell receptor
gene rearrangements; 1 (8%) of 13 PLC specimens showed a gene rearrangement
(P = .008, Fisher exact test). CONCLUSIONS Our results demonstrate the polyclonal nature of the lymphocytic infiltrate
found in almost all of the PLC specimens, which contrasts with the monoclonal
nature found in most of the PLEVA specimens. These differences may represent
different stages of the clinical evolution of a single entity that results
from varying host immune responses to pathogenic factors. Specifically, we
propose that PLEVA is a benign clonal T-cell disorder in which the clone arises
from a subset of T cells in lesions of PLC. The host immune response to this
clone determines the clinical and histologic findings in PLEVA.Arch Dermatol. 2002;138:1063-1067--></description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Clonal Anergy - genetics</subject><subject>Dermatology</subject><subject>Female</subject><subject>Gene Order - genetics</subject><subject>Genes, T-Cell Receptor - genetics</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pityriasis Lichenoides - complications</subject><subject>Pityriasis Lichenoides - genetics</subject><subject>Pityriasis Lichenoides - pathology</subject><subject>Prospective Studies</subject><subject>Retrospective Studies</subject><subject>Skin involvement in other diseases. Miscellaneous. General aspects</subject><issn>0003-987X</issn><issn>2168-6068</issn><issn>1538-3652</issn><issn>2168-6084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkF1LwzAUhoMobk5_gAhSBL2RzqSnzcelDL9gqBcTvAtpmrCMdtWkvdi_N2PVgVcHznneF86D0AXBU4IxuVNeLyvjmykBPuVxR-EAjUkBPAVaZIdojDGGVHD2OUInIaxiKOM8O0YjkhGaszwfo9vF0iSzul2rOnlVXe9N0trk3XUb71RwIZk7vTTr1lUmnKIjq-pgzoY5QR-PD4vZczp_e3qZ3c9TBYx2qa0sAUZ0QQsGpmQWNGBTYmpLCgU3AgjmihScUYuBi5xiLDJBDY6IygEm6GbX--Xb796ETjYuaFPXam3aPkhG4k8CcASv_oGrtvfxlSAzAAIZwyJCsIO0b0Pwxsov7xrlN5JguRUpf0XKKFJyuRUZU5dDdV82ptpnBnMRuB4AFbSqrVdr7cKeA54LxnjkznecatTfNWc8WoAfXBCCrg</recordid><startdate>20020801</startdate><enddate>20020801</enddate><creator>Weinberg, Jeffrey M</creator><creator>Kristal, Leonard</creator><creator>Chooback, Lillian</creator><creator>Honig, Paul J</creator><creator>Kramer, E. Michael</creator><creator>Lessin, Stuart R</creator><general>American Medical Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20020801</creationdate><title>The Clonal Nature of Pityriasis Lichenoides</title><author>Weinberg, Jeffrey M ; Kristal, Leonard ; Chooback, Lillian ; Honig, Paul J ; Kramer, E. Michael ; Lessin, Stuart R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a376t-fdf1371c56573eb7f3c30eb06fb6358e93108a15876f038946009296e006fa433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Clonal Anergy - genetics</topic><topic>Dermatology</topic><topic>Female</topic><topic>Gene Order - genetics</topic><topic>Genes, T-Cell Receptor - genetics</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pityriasis Lichenoides - complications</topic><topic>Pityriasis Lichenoides - genetics</topic><topic>Pityriasis Lichenoides - pathology</topic><topic>Prospective Studies</topic><topic>Retrospective Studies</topic><topic>Skin involvement in other diseases. Miscellaneous. General aspects</topic><toplevel>online_resources</toplevel><creatorcontrib>Weinberg, Jeffrey M</creatorcontrib><creatorcontrib>Kristal, Leonard</creatorcontrib><creatorcontrib>Chooback, Lillian</creatorcontrib><creatorcontrib>Honig, Paul J</creatorcontrib><creatorcontrib>Kramer, E. Michael</creatorcontrib><creatorcontrib>Lessin, Stuart R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of dermatology (1960)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Weinberg, Jeffrey M</au><au>Kristal, Leonard</au><au>Chooback, Lillian</au><au>Honig, Paul J</au><au>Kramer, E. Michael</au><au>Lessin, Stuart R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Clonal Nature of Pityriasis Lichenoides</atitle><jtitle>Archives of dermatology (1960)</jtitle><addtitle>Arch Dermatol</addtitle><date>2002-08-01</date><risdate>2002</risdate><volume>138</volume><issue>8</issue><spage>1063</spage><epage>1067</epage><pages>1063-1067</pages><issn>0003-987X</issn><issn>2168-6068</issn><eissn>1538-3652</eissn><eissn>2168-6084</eissn><coden>ARDEAC</coden><abstract>BACKGROUND Pityriasis lichenoides et varioliformis acuta (PLEVA) and pityriasis
lichenoides chronica (PLC) are benign lymphocytic infiltrates of the skin
that classically present as either a recurrent papulonecrotic eruption (PLEVA)
or a persistent, scaling, papular eruption (PLC). Observations of both types
of lesions present on individual patients have led to speculation that both
entities are related. Previous studies evaluating the DNA of biopsy specimens
from patients with PLEVA and PLC revealed clonal T-cell receptor β gene
rearrangements. OBJECTIVE To analyze and compare the T-cell populations between lesions of PLEVA
and PLC. DESIGN Retrospective and prospective analysis of patient tissue samples, classified
by histologic analysis. Extracted DNA from 13 skin biopsy specimens with the
diagnosis of PLC and 14 skin biopsy specimens with the diagnosis of PLEVA
was analyzed by polymerase chain reaction/denaturing gradient gel electrophoresis
(PCR/DGGE). SETTING Molecular diagnostic laboratory at an academic medical center. PATIENTS Twenty-seven tissue samples were obtained from patients with a histologic
diagnosis of PLEVA or PLC. These samples were analyzed by PCR/DGGE. MAIN OUTCOME MEASURE The presence or absence of T-cell receptor gene rearrangements on PCR/DGGE
analysis corresponding to a clonal population of T cells. RESULTS Of 14 PLEVA specimens, 8 (57%) demonstrated monoclonal T-cell receptor
gene rearrangements; 1 (8%) of 13 PLC specimens showed a gene rearrangement
(P = .008, Fisher exact test). CONCLUSIONS Our results demonstrate the polyclonal nature of the lymphocytic infiltrate
found in almost all of the PLC specimens, which contrasts with the monoclonal
nature found in most of the PLEVA specimens. These differences may represent
different stages of the clinical evolution of a single entity that results
from varying host immune responses to pathogenic factors. Specifically, we
propose that PLEVA is a benign clonal T-cell disorder in which the clone arises
from a subset of T cells in lesions of PLC. The host immune response to this
clone determines the clinical and histologic findings in PLEVA.Arch Dermatol. 2002;138:1063-1067--></abstract><cop>Chicago, IL</cop><pub>American Medical Association</pub><pmid>12164744</pmid><doi>10.1001/archderm.138.8.1063</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0003-987X |
| ispartof | Archives of dermatology (1960), 2002-08, Vol.138 (8), p.1063-1067 |
| issn | 0003-987X 2168-6068 1538-3652 2168-6084 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71987930 |
| source | MEDLINE; American Medical Association Journals |
| subjects | Adolescent Adult Aged Biological and medical sciences Child Child, Preschool Clonal Anergy - genetics Dermatology Female Gene Order - genetics Genes, T-Cell Receptor - genetics Humans Infant Male Medical sciences Middle Aged Pityriasis Lichenoides - complications Pityriasis Lichenoides - genetics Pityriasis Lichenoides - pathology Prospective Studies Retrospective Studies Skin involvement in other diseases. Miscellaneous. General aspects |
| title | The Clonal Nature of Pityriasis Lichenoides |
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