Behavioral Differences Among 129 Substrains: Implications for Knockout and Transgenic Mice

Most knockout (KO) mice are produced with embryonic stem cells derived from a 129 strain. Because most KO strains are backcrossed to B6 yet retain a portion of their genome from 129, especially around the ablated target locus, phenotypes previously attributed to the ablated locus may be due to passe...

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Veröffentlicht in:	Behavioral neuroscience 2002-08, Vol.116 (4), p.600-611
Hauptverfasser:	Cook, Melloni N, Bolivar, Valerie J, McFadyen, Melanie P, Flaherty, Lorraine
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Animal behavior Animal Ethology Animal Strain Differences Animals Anxiety Behavior, Animal Behavioral Genetics Biological and medical sciences Fear Fundamental and applied biological sciences. Psychology Genes Genetics Habituation Mammalia Maze Learning Mazes Mice Mice, Knockout Mice, Transgenic Phenotype Phenotypes Psychology. Psychoanalysis. Psychiatry Reproducibility of Results Rodents Selective breeding Vertebrata
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