Behavioral Differences Among 129 Substrains: Implications for Knockout and Transgenic Mice
Most knockout (KO) mice are produced with embryonic stem cells derived from a 129 strain. Because most KO strains are backcrossed to B6 yet retain a portion of their genome from 129, especially around the ablated target locus, phenotypes previously attributed to the ablated locus may be due to passe...
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| Veröffentlicht in: | Behavioral neuroscience 2002-08, Vol.116 (4), p.600-611 |
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| creator | Cook, Melloni N Bolivar, Valerie J McFadyen, Melanie P Flaherty, Lorraine |
| description | Most knockout (KO) mice are produced with embryonic stem cells derived from a
129 strain. Because most KO strains are backcrossed to B6 yet retain a portion
of their genome from 129, especially around the ablated target locus, phenotypes
previously attributed to the ablated locus may be due to passenger 129 genes.
Thus, the authors decided to test several 129 substrains for their behavioral
characteristics. Seven 129 substrains were put through a battery of tasks to
determine their behavioral profiles. Differences were found in anxiety-related
behaviors in the zero-maze, habituation to the open field, and cued fear
conditioning. All strains successfully performed the rotorod task. The
behavioral differences observed may have important implications for the
interpretation of data and show divergence of behavioral performance in these
129 substrains. |
| doi_str_mv | 10.1037/0735-7044.116.4.600 |
| format | Article |
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129 strain. Because most KO strains are backcrossed to B6 yet retain a portion
of their genome from 129, especially around the ablated target locus, phenotypes
previously attributed to the ablated locus may be due to passenger 129 genes.
Thus, the authors decided to test several 129 substrains for their behavioral
characteristics. Seven 129 substrains were put through a battery of tasks to
determine their behavioral profiles. Differences were found in anxiety-related
behaviors in the zero-maze, habituation to the open field, and cued fear
conditioning. All strains successfully performed the rotorod task. The
behavioral differences observed may have important implications for the
interpretation of data and show divergence of behavioral performance in these
129 substrains.</description><identifier>ISSN: 0735-7044</identifier><identifier>EISSN: 1939-0084</identifier><identifier>DOI: 10.1037/0735-7044.116.4.600</identifier><identifier>PMID: 12148927</identifier><identifier>CODEN: BENEDJ</identifier><language>eng</language><publisher>Washington, DC: American Psychological Association</publisher><subject>Animal ; Animal behavior ; Animal Ethology ; Animal Strain Differences ; Animals ; Anxiety ; Behavior, Animal ; Behavioral Genetics ; Biological and medical sciences ; Fear ; Fundamental and applied biological sciences. Psychology ; Genes ; Genetics ; Habituation ; Mammalia ; Maze Learning ; Mazes ; Mice ; Mice, Knockout ; Mice, Transgenic ; Phenotype ; Phenotypes ; Psychology. Psychoanalysis. Psychiatry ; Reproducibility of Results ; Rodents ; Selective breeding ; Vertebrata</subject><ispartof>Behavioral neuroscience, 2002-08, Vol.116 (4), p.600-611</ispartof><rights>2002 American Psychological Association</rights><rights>2002 INIST-CNRS</rights><rights>Copyright American Psychological Association Aug 2002</rights><rights>2002, American Psychological Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a361t-a0e471e76281e1fdb2af23399d3d5897b9c6a124a40b1853aab43c239794f22e3</citedby><cites>FETCH-LOGICAL-a361t-a0e471e76281e1fdb2af23399d3d5897b9c6a124a40b1853aab43c239794f22e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13807135$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12148927$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cook, Melloni N</creatorcontrib><creatorcontrib>Bolivar, Valerie J</creatorcontrib><creatorcontrib>McFadyen, Melanie P</creatorcontrib><creatorcontrib>Flaherty, Lorraine</creatorcontrib><title>Behavioral Differences Among 129 Substrains: Implications for Knockout and Transgenic Mice</title><title>Behavioral neuroscience</title><addtitle>Behav Neurosci</addtitle><description>Most knockout (KO) mice are produced with embryonic stem cells derived from a
129 strain. Because most KO strains are backcrossed to B6 yet retain a portion
of their genome from 129, especially around the ablated target locus, phenotypes
previously attributed to the ablated locus may be due to passenger 129 genes.
Thus, the authors decided to test several 129 substrains for their behavioral
characteristics. Seven 129 substrains were put through a battery of tasks to
determine their behavioral profiles. Differences were found in anxiety-related
behaviors in the zero-maze, habituation to the open field, and cued fear
conditioning. All strains successfully performed the rotorod task. The
behavioral differences observed may have important implications for the
interpretation of data and show divergence of behavioral performance in these
129 substrains.</description><subject>Animal</subject><subject>Animal behavior</subject><subject>Animal Ethology</subject><subject>Animal Strain Differences</subject><subject>Animals</subject><subject>Anxiety</subject><subject>Behavior, Animal</subject><subject>Behavioral Genetics</subject><subject>Biological and medical sciences</subject><subject>Fear</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genes</subject><subject>Genetics</subject><subject>Habituation</subject><subject>Mammalia</subject><subject>Maze Learning</subject><subject>Mazes</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Mice, Transgenic</subject><subject>Phenotype</subject><subject>Phenotypes</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Reproducibility of Results</subject><subject>Rodents</subject><subject>Selective breeding</subject><subject>Vertebrata</subject><issn>0735-7044</issn><issn>1939-0084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U1LAzEQBuAgitaPXyBIEfQiW2eS7CY51m9B8KCew2ya1ZXtbk26gv_eFIsVD3rK5ZkJ77yM7SOMEIQ6BSXyTIGUI8RiJEcFwBoboBEmA9BynQ2-xRbbjvEVACTIfJNtIUepDVcDdnLmX-i97gI1w4u6qnzwrfNxOJ527fMQuRk-9GWcB6rbuMs2Kmqi31u-O-zp6vLx_Ca7u7--PR_fZSQKnGcEXir0quAaPVaTklPFhTBmIia5Nqo0riDkkiSUqHNBVErhuDDKyIpzL3bY8dfeWejeeh_ndlpH55uGWt_10So0WqEq_oWotdIpa4KHv-Br14c2hbAFSim4luovxEEYKFK6hMQXcqGLMfjKzkI9pfBhEeyiFrs4ul0c3aZarLSpljR1sFzdl1M_Wc0se0jgaAkoOmqqQK2r48oJDQpFvnI0IzuLH47CvHaNj7Zs_Y8PPwHMvJ0D</recordid><startdate>200208</startdate><enddate>200208</enddate><creator>Cook, Melloni N</creator><creator>Bolivar, Valerie J</creator><creator>McFadyen, Melanie P</creator><creator>Flaherty, Lorraine</creator><general>American Psychological Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7RZ</scope><scope>PSYQQ</scope><scope>7X8</scope></search><sort><creationdate>200208</creationdate><title>Behavioral Differences Among 129 Substrains</title><author>Cook, Melloni N ; Bolivar, Valerie J ; McFadyen, Melanie P ; Flaherty, Lorraine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a361t-a0e471e76281e1fdb2af23399d3d5897b9c6a124a40b1853aab43c239794f22e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animal</topic><topic>Animal behavior</topic><topic>Animal Ethology</topic><topic>Animal Strain Differences</topic><topic>Animals</topic><topic>Anxiety</topic><topic>Behavior, Animal</topic><topic>Behavioral Genetics</topic><topic>Biological and medical sciences</topic><topic>Fear</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genes</topic><topic>Genetics</topic><topic>Habituation</topic><topic>Mammalia</topic><topic>Maze Learning</topic><topic>Mazes</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Mice, Transgenic</topic><topic>Phenotype</topic><topic>Phenotypes</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Reproducibility of Results</topic><topic>Rodents</topic><topic>Selective breeding</topic><topic>Vertebrata</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cook, Melloni N</creatorcontrib><creatorcontrib>Bolivar, Valerie J</creatorcontrib><creatorcontrib>McFadyen, Melanie P</creatorcontrib><creatorcontrib>Flaherty, Lorraine</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>APA PsycArticles®</collection><collection>ProQuest One Psychology</collection><collection>MEDLINE - Academic</collection><jtitle>Behavioral neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cook, Melloni N</au><au>Bolivar, Valerie J</au><au>McFadyen, Melanie P</au><au>Flaherty, Lorraine</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Behavioral Differences Among 129 Substrains: Implications for Knockout and Transgenic Mice</atitle><jtitle>Behavioral neuroscience</jtitle><addtitle>Behav Neurosci</addtitle><date>2002-08</date><risdate>2002</risdate><volume>116</volume><issue>4</issue><spage>600</spage><epage>611</epage><pages>600-611</pages><issn>0735-7044</issn><eissn>1939-0084</eissn><coden>BENEDJ</coden><abstract>Most knockout (KO) mice are produced with embryonic stem cells derived from a
129 strain. Because most KO strains are backcrossed to B6 yet retain a portion
of their genome from 129, especially around the ablated target locus, phenotypes
previously attributed to the ablated locus may be due to passenger 129 genes.
Thus, the authors decided to test several 129 substrains for their behavioral
characteristics. Seven 129 substrains were put through a battery of tasks to
determine their behavioral profiles. Differences were found in anxiety-related
behaviors in the zero-maze, habituation to the open field, and cued fear
conditioning. All strains successfully performed the rotorod task. The
behavioral differences observed may have important implications for the
interpretation of data and show divergence of behavioral performance in these
129 substrains.</abstract><cop>Washington, DC</cop><pub>American Psychological Association</pub><pmid>12148927</pmid><doi>10.1037/0735-7044.116.4.600</doi><tpages>12</tpages></addata></record> |
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| subjects | Animal Animal behavior Animal Ethology Animal Strain Differences Animals Anxiety Behavior, Animal Behavioral Genetics Biological and medical sciences Fear Fundamental and applied biological sciences. Psychology Genes Genetics Habituation Mammalia Maze Learning Mazes Mice Mice, Knockout Mice, Transgenic Phenotype Phenotypes Psychology. Psychoanalysis. Psychiatry Reproducibility of Results Rodents Selective breeding Vertebrata |
| title | Behavioral Differences Among 129 Substrains: Implications for Knockout and Transgenic Mice |
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