Cardiac effects of low-dose growth hormone replacement therapy in growth hormone-deficient adults. An 18-month randomised, placebo-controlled, double-blind study
To characterise the effect of long-term low-dose growth hormone (GH) treatment on cardiac anatomy and function. 20 patients with multiple pituitary hormone deficiencies, including severe acquired GH deficiency (GHD), were randomly assigned to GH or placebo (P) for 18 months. Echocardiographic measur...
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| Veröffentlicht in: | Hormone research 2002, Vol.58 (1), p.21-29 |
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| creator | Sneppen, Simone B Steensgaard-Hansen, Frank Feldt-Rasmussen, Ulla |
| description | To characterise the effect of long-term low-dose growth hormone (GH) treatment on cardiac anatomy and function.
20 patients with multiple pituitary hormone deficiencies, including severe acquired GH deficiency (GHD), were randomly assigned to GH or placebo (P) for 18 months. Echocardiographic measurements were performed at baseline and after 6, 12 and 18 months.
At baseline, 8 of 20 patients had diastolic dysfunction (6 severe and 2 borderline), while only 1 had systolic dysfunction. None of the investigated parameters of diastolic or systolic function changed during treatment.
In adult onset GHD, diastolic dysfunction was present in 40% of the patients. None of the investigated values were different after 18 months of GH compared to placebo. |
| doi_str_mv | 10.1159/000063212 |
| format | Article |
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20 patients with multiple pituitary hormone deficiencies, including severe acquired GH deficiency (GHD), were randomly assigned to GH or placebo (P) for 18 months. Echocardiographic measurements were performed at baseline and after 6, 12 and 18 months.
At baseline, 8 of 20 patients had diastolic dysfunction (6 severe and 2 borderline), while only 1 had systolic dysfunction. None of the investigated parameters of diastolic or systolic function changed during treatment.
In adult onset GHD, diastolic dysfunction was present in 40% of the patients. None of the investigated values were different after 18 months of GH compared to placebo.</description><identifier>ISSN: 0301-0163</identifier><identifier>ISSN: 1663-2818</identifier><identifier>EISSN: 1663-2826</identifier><identifier>DOI: 10.1159/000063212</identifier><identifier>PMID: 12169777</identifier><language>eng</language><publisher>Switzerland: S. Karger AG</publisher><subject>Adenoma - drug therapy ; Adult ; Craniopharyngioma - drug therapy ; Cushing Syndrome - drug therapy ; Double-Blind Method ; Female ; Heart - anatomy & histology ; Heart - physiology ; Human Growth Hormone - deficiency ; Human Growth Hormone - therapeutic use ; Humans ; Male ; Middle Aged ; Myocardial Contraction - drug effects ; Pituitary Neoplasms - drug therapy ; Prolactinoma - drug therapy ; Treatment Outcome ; Ventricular Dysfunction, Left - mortality</subject><ispartof>Hormone research, 2002, Vol.58 (1), p.21-29</ispartof><rights>Copyright 2002 S. Karger AG, Basel</rights><rights>Copyright (c) 2002 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12169777$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sneppen, Simone B</creatorcontrib><creatorcontrib>Steensgaard-Hansen, Frank</creatorcontrib><creatorcontrib>Feldt-Rasmussen, Ulla</creatorcontrib><title>Cardiac effects of low-dose growth hormone replacement therapy in growth hormone-deficient adults. An 18-month randomised, placebo-controlled, double-blind study</title><title>Hormone research</title><addtitle>Horm Res</addtitle><description>To characterise the effect of long-term low-dose growth hormone (GH) treatment on cardiac anatomy and function.
20 patients with multiple pituitary hormone deficiencies, including severe acquired GH deficiency (GHD), were randomly assigned to GH or placebo (P) for 18 months. Echocardiographic measurements were performed at baseline and after 6, 12 and 18 months.
At baseline, 8 of 20 patients had diastolic dysfunction (6 severe and 2 borderline), while only 1 had systolic dysfunction. None of the investigated parameters of diastolic or systolic function changed during treatment.
In adult onset GHD, diastolic dysfunction was present in 40% of the patients. None of the investigated values were different after 18 months of GH compared to placebo.</description><subject>Adenoma - drug therapy</subject><subject>Adult</subject><subject>Craniopharyngioma - drug therapy</subject><subject>Cushing Syndrome - drug therapy</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Heart - anatomy & histology</subject><subject>Heart - physiology</subject><subject>Human Growth Hormone - deficiency</subject><subject>Human Growth Hormone - therapeutic use</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardial Contraction - drug effects</subject><subject>Pituitary Neoplasms - drug therapy</subject><subject>Prolactinoma - drug therapy</subject><subject>Treatment Outcome</subject><subject>Ventricular Dysfunction, Left - mortality</subject><issn>0301-0163</issn><issn>1663-2818</issn><issn>1663-2826</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpd0M1q3DAQB3BRUppt2kNfoAgCPVWpRrIl-xiWfgQCuTRnM5bGXQfZciSbsI_TN43SJpfMZWD-P4ZhGPsE8gKgbr_JUkYrUG_YDozRQjXKnLCd1BKEBKNP2fuc76QsuKnfsVNQYFpr7Y793WPyIzpOw0BuzTwOPMQH4WMm_ifFh_XADzFNcSaeaAnoaKJ55euBEi5HPs6vlPA0jG58Mui3sOYLfjlzaEQJi0o4-ziNmfxX_m9bH4UrSYohPM183PpAog_j7HleN3_8wN4OGDJ9fO5n7PbH99_7X-L65ufV_vJaLErXq0AgZyslB8K6blyPYJw1UBEitOCc0bonhRap6StrZAmIKiltVaNqW9Rn7Mv_vUuK9xvltStnOgoBZ4pb7iy0jZXQFHj-Ct7FLc3ltg6kaZWysoKiPj-rrZ_Id0saJ0zH7uX1-hHVmocJ</recordid><startdate>2002</startdate><enddate>2002</enddate><creator>Sneppen, Simone B</creator><creator>Steensgaard-Hansen, Frank</creator><creator>Feldt-Rasmussen, Ulla</creator><general>S. 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An 18-month randomised, placebo-controlled, double-blind study</atitle><jtitle>Hormone research</jtitle><addtitle>Horm Res</addtitle><date>2002</date><risdate>2002</risdate><volume>58</volume><issue>1</issue><spage>21</spage><epage>29</epage><pages>21-29</pages><issn>0301-0163</issn><issn>1663-2818</issn><eissn>1663-2826</eissn><abstract>To characterise the effect of long-term low-dose growth hormone (GH) treatment on cardiac anatomy and function.
20 patients with multiple pituitary hormone deficiencies, including severe acquired GH deficiency (GHD), were randomly assigned to GH or placebo (P) for 18 months. Echocardiographic measurements were performed at baseline and after 6, 12 and 18 months.
At baseline, 8 of 20 patients had diastolic dysfunction (6 severe and 2 borderline), while only 1 had systolic dysfunction. None of the investigated parameters of diastolic or systolic function changed during treatment.
In adult onset GHD, diastolic dysfunction was present in 40% of the patients. None of the investigated values were different after 18 months of GH compared to placebo.</abstract><cop>Switzerland</cop><pub>S. Karger AG</pub><pmid>12169777</pmid><doi>10.1159/000063212</doi><tpages>9</tpages></addata></record> |
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| ispartof | Hormone research, 2002, Vol.58 (1), p.21-29 |
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| language | eng |
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| source | MEDLINE; Karger Journals; Alma/SFX Local Collection |
| subjects | Adenoma - drug therapy Adult Craniopharyngioma - drug therapy Cushing Syndrome - drug therapy Double-Blind Method Female Heart - anatomy & histology Heart - physiology Human Growth Hormone - deficiency Human Growth Hormone - therapeutic use Humans Male Middle Aged Myocardial Contraction - drug effects Pituitary Neoplasms - drug therapy Prolactinoma - drug therapy Treatment Outcome Ventricular Dysfunction, Left - mortality |
| title | Cardiac effects of low-dose growth hormone replacement therapy in growth hormone-deficient adults. An 18-month randomised, placebo-controlled, double-blind study |
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