Biologically active steroidal glycosides from Tribulus terrestris
The steroidal saponin constituents obtained from Tribulus terrestris were tested for their antimicrobial and cytotoxic effects. The spirostanol-based steroidal saponins 1-3 exhibited remarkable activity against fungal organisms (Candida albicans and Cryptococcus neoformans) and cancer cell lines [hu...
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| Veröffentlicht in: | Pharmazie 2002-07, Vol.57 (7), p.491-493 |
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| creator | BEDIR, E KHAN, I. A WALKER, L. A |
| description | The steroidal saponin constituents obtained from Tribulus terrestris were tested for their antimicrobial and cytotoxic effects. The spirostanol-based steroidal saponins 1-3 exhibited remarkable activity against fungal organisms (Candida albicans and Cryptococcus neoformans) and cancer cell lines [human malignant melanoma (SK-MEL), human oral epidermoid carcinoma (KB), human breast ductal carcinoma (BT-549), and human ovary carcinoma (SK-OV-3)], while none of the compounds possessing the furostanol framework 4-7 showed activity. The most active spirostanol glycoside, compound 3 exhibited a broad range of anticancer activity against cell lines, SK-MEL, KB, BT-549 and SK-OV-3 at IC50s of 6.0, 7.0, 6.0 and 8.2 micrograms/ml, respectively, while compounds 1 and 2 showed selective cytotoxicity against SK-MEL at 6.7 and 9.1 micrograms/ml, respectively. The minimum inhibitory concentrations (MIC) in antifungal bioassay for compounds 1-3 varied from 1.5 to 6.2 micrograms/ml, which prompted to conclude certain structural features are required for these bioactivities. |
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A ; WALKER, L. A</creator><creatorcontrib>BEDIR, E ; KHAN, I. A ; WALKER, L. A</creatorcontrib><description>The steroidal saponin constituents obtained from Tribulus terrestris were tested for their antimicrobial and cytotoxic effects. The spirostanol-based steroidal saponins 1-3 exhibited remarkable activity against fungal organisms (Candida albicans and Cryptococcus neoformans) and cancer cell lines [human malignant melanoma (SK-MEL), human oral epidermoid carcinoma (KB), human breast ductal carcinoma (BT-549), and human ovary carcinoma (SK-OV-3)], while none of the compounds possessing the furostanol framework 4-7 showed activity. The most active spirostanol glycoside, compound 3 exhibited a broad range of anticancer activity against cell lines, SK-MEL, KB, BT-549 and SK-OV-3 at IC50s of 6.0, 7.0, 6.0 and 8.2 micrograms/ml, respectively, while compounds 1 and 2 showed selective cytotoxicity against SK-MEL at 6.7 and 9.1 micrograms/ml, respectively. The minimum inhibitory concentrations (MIC) in antifungal bioassay for compounds 1-3 varied from 1.5 to 6.2 micrograms/ml, which prompted to conclude certain structural features are required for these bioactivities.</description><identifier>ISSN: 0031-7144</identifier><identifier>PMID: 12168535</identifier><identifier>CODEN: PHARAT</identifier><language>eng</language><publisher>Eschborn: Govi</publisher><subject>Anti-Bacterial Agents ; Anti-Infective Agents - isolation & purification ; Anti-Infective Agents - pharmacology ; Antifungal Agents - isolation & purification ; Antifungal Agents - pharmacology ; Antineoplastic Agents, Phytogenic - isolation & purification ; Antineoplastic Agents, Phytogenic - pharmacology ; Bacteria - drug effects ; Biological and medical sciences ; Drug Screening Assays, Antitumor ; Fungi - drug effects ; General pharmacology ; Glycosides - isolation & purification ; Glycosides - pharmacology ; Humans ; Medical sciences ; Microbial Sensitivity Tests ; Pharmacognosy. 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A</creatorcontrib><creatorcontrib>WALKER, L. A</creatorcontrib><title>Biologically active steroidal glycosides from Tribulus terrestris</title><title>Pharmazie</title><addtitle>Pharmazie</addtitle><description>The steroidal saponin constituents obtained from Tribulus terrestris were tested for their antimicrobial and cytotoxic effects. The spirostanol-based steroidal saponins 1-3 exhibited remarkable activity against fungal organisms (Candida albicans and Cryptococcus neoformans) and cancer cell lines [human malignant melanoma (SK-MEL), human oral epidermoid carcinoma (KB), human breast ductal carcinoma (BT-549), and human ovary carcinoma (SK-OV-3)], while none of the compounds possessing the furostanol framework 4-7 showed activity. The most active spirostanol glycoside, compound 3 exhibited a broad range of anticancer activity against cell lines, SK-MEL, KB, BT-549 and SK-OV-3 at IC50s of 6.0, 7.0, 6.0 and 8.2 micrograms/ml, respectively, while compounds 1 and 2 showed selective cytotoxicity against SK-MEL at 6.7 and 9.1 micrograms/ml, respectively. The minimum inhibitory concentrations (MIC) in antifungal bioassay for compounds 1-3 varied from 1.5 to 6.2 micrograms/ml, which prompted to conclude certain structural features are required for these bioactivities.</description><subject>Anti-Bacterial Agents</subject><subject>Anti-Infective Agents - isolation & purification</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Antifungal Agents - isolation & purification</subject><subject>Antifungal Agents - pharmacology</subject><subject>Antineoplastic Agents, Phytogenic - isolation & purification</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>Bacteria - drug effects</subject><subject>Biological and medical sciences</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Fungi - drug effects</subject><subject>General pharmacology</subject><subject>Glycosides - isolation & purification</subject><subject>Glycosides - pharmacology</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plants, Medicinal - chemistry</subject><subject>Steroids - isolation & purification</subject><subject>Steroids - pharmacology</subject><subject>Tumor Cells, Cultured</subject><subject>Zygophyllaceae - chemistry</subject><subject>Zygophyllaceae - metabolism</subject><issn>0031-7144</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFz0tLAzEUBeAsFFurf0Fmo7uB3LxnWYsvKLip6yGTSUok09TcGaH_3gErrs7m4xzOBVlSyqHWIMSCXCN-UsoUU-aKLICBMpLLJVk_xpzyPjqb0qmybozfvsLRlxx7m6p9OrmMsfdYhZKHaldiN6UJq1kUj2OJeEMug03ob8-5Ih_PT7vNa719f3nbrLf1kXE91lwrroAL19NeS2gsAymCsSJYA-Asl9BxH1wvTQAqtVCegmRGdFIH2TV8RR5-e48lf03zdjtEdD4le_B5wlZDY5Rp9AzvznDqBt-3xxIHW07t3-kZ3J-Bxfl3KPbgIv47rjUzSvAfRSte8w</recordid><startdate>20020701</startdate><enddate>20020701</enddate><creator>BEDIR, E</creator><creator>KHAN, I. 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A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p237t-37636134cd0d7519a2154f8a4fa811ca351b3efcd58f105746e015284b57f5b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Anti-Bacterial Agents</topic><topic>Anti-Infective Agents - isolation & purification</topic><topic>Anti-Infective Agents - pharmacology</topic><topic>Antifungal Agents - isolation & purification</topic><topic>Antifungal Agents - pharmacology</topic><topic>Antineoplastic Agents, Phytogenic - isolation & purification</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>Bacteria - drug effects</topic><topic>Biological and medical sciences</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Fungi - drug effects</topic><topic>General pharmacology</topic><topic>Glycosides - isolation & purification</topic><topic>Glycosides - pharmacology</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plants, Medicinal - chemistry</topic><topic>Steroids - isolation & purification</topic><topic>Steroids - pharmacology</topic><topic>Tumor Cells, Cultured</topic><topic>Zygophyllaceae - chemistry</topic><topic>Zygophyllaceae - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BEDIR, E</creatorcontrib><creatorcontrib>KHAN, I. A</creatorcontrib><creatorcontrib>WALKER, L. A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmazie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BEDIR, E</au><au>KHAN, I. A</au><au>WALKER, L. A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biologically active steroidal glycosides from Tribulus terrestris</atitle><jtitle>Pharmazie</jtitle><addtitle>Pharmazie</addtitle><date>2002-07-01</date><risdate>2002</risdate><volume>57</volume><issue>7</issue><spage>491</spage><epage>493</epage><pages>491-493</pages><issn>0031-7144</issn><coden>PHARAT</coden><abstract>The steroidal saponin constituents obtained from Tribulus terrestris were tested for their antimicrobial and cytotoxic effects. The spirostanol-based steroidal saponins 1-3 exhibited remarkable activity against fungal organisms (Candida albicans and Cryptococcus neoformans) and cancer cell lines [human malignant melanoma (SK-MEL), human oral epidermoid carcinoma (KB), human breast ductal carcinoma (BT-549), and human ovary carcinoma (SK-OV-3)], while none of the compounds possessing the furostanol framework 4-7 showed activity. The most active spirostanol glycoside, compound 3 exhibited a broad range of anticancer activity against cell lines, SK-MEL, KB, BT-549 and SK-OV-3 at IC50s of 6.0, 7.0, 6.0 and 8.2 micrograms/ml, respectively, while compounds 1 and 2 showed selective cytotoxicity against SK-MEL at 6.7 and 9.1 micrograms/ml, respectively. The minimum inhibitory concentrations (MIC) in antifungal bioassay for compounds 1-3 varied from 1.5 to 6.2 micrograms/ml, which prompted to conclude certain structural features are required for these bioactivities.</abstract><cop>Eschborn</cop><pub>Govi</pub><pmid>12168535</pmid><tpages>3</tpages></addata></record> |
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| subjects | Anti-Bacterial Agents Anti-Infective Agents - isolation & purification Anti-Infective Agents - pharmacology Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Bacteria - drug effects Biological and medical sciences Drug Screening Assays, Antitumor Fungi - drug effects General pharmacology Glycosides - isolation & purification Glycosides - pharmacology Humans Medical sciences Microbial Sensitivity Tests Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal - chemistry Steroids - isolation & purification Steroids - pharmacology Tumor Cells, Cultured Zygophyllaceae - chemistry Zygophyllaceae - metabolism |
| title | Biologically active steroidal glycosides from Tribulus terrestris |
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