Transforming growth factor-α: a surrogate endpoint biomarker?

BACKGROUND: Dysplastic oral leukoplakia (DOL) has been the index lesion in prevention trials for upper aerodigestive tract squamous cell carcinoma (SCC). Vitamin A derivatives, including 13-cis retinoic acid (13-CRA), have been used to treat DOL and to reduce the risk of subsequent SCC. Results from...

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Veröffentlicht in:	Journal of the American College of Surgeons 2002-08, Vol.195 (2), p.149-158
Hauptverfasser:	Beenken, Samuel W, Hockett, Richard, Grizzle, William, Weiss, Heidi L, Pickens, Allan, Perloff, Marjorie, Malone, Winfred F, Bland, Kirby I
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antineoplastic agents Biological and medical sciences Biomarkers, Tumor - metabolism Carcinoma, Squamous Cell - prevention & control Chemotherapy Disease Progression Double-Blind Method Female Gene Expression Regulation, Neoplastic - drug effects Humans Isotretinoin - therapeutic use Leukoplakia, Oral - drug therapy Leukoplakia, Oral - metabolism Male Medical sciences Mouth Neoplasms - prevention & control Pharmacology. Drug treatments Prospective Studies Receptor, Epidermal Growth Factor - drug effects Receptor, Epidermal Growth Factor - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Transforming Growth Factor alpha - metabolism
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