The pancake phenomenon contributes to the inaccuracy of margin assessment in patients with breast cancer
Background: To determine the effect on margin evaluation for patients with breast cancer, we prospectively quantified the “flattening” of the breast specimen after surgical removal. Methods: The volume and height of 100 consecutive breast biopsy specimens were recorded independently by the operating...
Gespeichert in:
| Veröffentlicht in: | The American journal of surgery 2002-08, Vol.184 (2), p.89-93 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 93 |
|---|---|
| container_issue | 2 |
| container_start_page | 89 |
| container_title | The American journal of surgery |
| container_volume | 184 |
| creator | Graham, Roger A Homer, Marc J Katz, Judith Rothschild, Janice Safaii, Homa Supran, Stacey |
| description | Background: To determine the effect on margin evaluation for patients with breast cancer, we prospectively quantified the “flattening” of the breast specimen after surgical removal.
Methods: The volume and height of 100 consecutive breast biopsy specimens were recorded independently by the operating surgeon and the pathologist. Five factors were analyzed that were thought to contribute to changes in specimen dimensions: patient age, breast tissue density, mammographic lesion type, specimen size, and the use of compression during specimen radiography.
Results: After surgical removal, mean volume and height of the breast specimens decreased from 46 cm
3 to 29 cm
3 (30%) and from 2.6 cm to 1.4 cm (46%), respectively. Flattening of the breast specimens occurred in all subgroups studied.
Conclusions: Breast specimens are flattened after surgical removal, losing almost 50% of their original height. This “pancake” phenomenon has important implications for the accuracy of margin analysis. |
| doi_str_mv | 10.1016/S0002-9610(02)00902-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71986284</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0002961002009029</els_id><sourcerecordid>2847455593</sourcerecordid><originalsourceid>FETCH-LOGICAL-c419t-c118bc6721fa9020ce194e869bba8b60413c5638f9b7d92aff08ffe95a9f1ed43</originalsourceid><addsrcrecordid>eNqFkU1vFDEMhiMEotvCTwBFQiA4DMTzmZwqVJUPqRIHyjnKZBw2ZXeyxBlQ_z3e7opKXDhEjuXHr-zXQjwD9RYU9O--KqXqyvSgXqv6jVJmnz0QK9CDqUDr5qFY_UVOxCnRDacAbfNYnEANvWlasxLr6zXKnZu9-8FxjXPa8pulT3PJcVwKkixJFqbi7LxfsvO3MgW5dfl7nKUjQiLuKVxnoRL5S_J3LGs5ZnRUpGd1zE_Eo-A2hE-P8Ux8-3B5ffGpuvry8fPF-6vKt2BK5QH06PuhhuB4JeURTIu6N-Po9NirFhrf9Y0OZhwmU7sQlA4BTedMAJza5ky8Oujucvq5IBW7jeRxs3EzpoXsAEb3td6DL_4Bb9KSZ57Ncnlou64zDVPdgfI5EWUMdpcj735rQdn9IezdIezeZcvx7hDWcN_zo_oybnG67zo6z8DLI-DIu03I7FKke67hEc0wMHd-4JBN-xUxW_LssccpZvTFTin-Z5Q_xY6lnA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2847455593</pqid></control><display><type>article</type><title>The pancake phenomenon contributes to the inaccuracy of margin assessment in patients with breast cancer</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><source>ProQuest Central UK/Ireland</source><creator>Graham, Roger A ; Homer, Marc J ; Katz, Judith ; Rothschild, Janice ; Safaii, Homa ; Supran, Stacey</creator><creatorcontrib>Graham, Roger A ; Homer, Marc J ; Katz, Judith ; Rothschild, Janice ; Safaii, Homa ; Supran, Stacey</creatorcontrib><description>Background: To determine the effect on margin evaluation for patients with breast cancer, we prospectively quantified the “flattening” of the breast specimen after surgical removal.
Methods: The volume and height of 100 consecutive breast biopsy specimens were recorded independently by the operating surgeon and the pathologist. Five factors were analyzed that were thought to contribute to changes in specimen dimensions: patient age, breast tissue density, mammographic lesion type, specimen size, and the use of compression during specimen radiography.
Results: After surgical removal, mean volume and height of the breast specimens decreased from 46 cm
3 to 29 cm
3 (30%) and from 2.6 cm to 1.4 cm (46%), respectively. Flattening of the breast specimens occurred in all subgroups studied.
Conclusions: Breast specimens are flattened after surgical removal, losing almost 50% of their original height. This “pancake” phenomenon has important implications for the accuracy of margin analysis.</description><identifier>ISSN: 0002-9610</identifier><identifier>EISSN: 1879-1883</identifier><identifier>DOI: 10.1016/S0002-9610(02)00902-9</identifier><identifier>PMID: 12169349</identifier><identifier>CODEN: AJSUAB</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Biopsy ; Biopsy, Needle ; Breast cancer ; Breast Diseases - diagnostic imaging ; Breast Diseases - pathology ; Breast Diseases - surgery ; Breast Neoplasms - diagnostic imaging ; Breast Neoplasms - pathology ; Breast Neoplasms - surgery ; Culture Techniques ; Diagnosis, Differential ; Female ; Flattening ; Gynecology. Andrology. Obstetrics ; Humans ; Immunohistochemistry ; Localization ; Mammary gland diseases ; Mammography ; Mammography - methods ; Margin assessment ; Mastectomy ; Medical sciences ; Middle Aged ; Neoplasm Invasiveness - pathology ; Pathology ; Patients ; Probability ; Prospective Studies ; Radiation therapy ; Radiography ; Reference Values ; Regression analysis ; Sensitivity and Specificity ; Specimen radiography ; Subgroups ; Surgeons ; Surgery ; Tumors ; Variance analysis</subject><ispartof>The American journal of surgery, 2002-08, Vol.184 (2), p.89-93</ispartof><rights>2002 Excerpta Medica Inc.</rights><rights>2002 INIST-CNRS</rights><rights>2002. Excerpta Medica Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-c118bc6721fa9020ce194e869bba8b60413c5638f9b7d92aff08ffe95a9f1ed43</citedby><cites>FETCH-LOGICAL-c419t-c118bc6721fa9020ce194e869bba8b60413c5638f9b7d92aff08ffe95a9f1ed43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2847455593?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13843977$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12169349$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Graham, Roger A</creatorcontrib><creatorcontrib>Homer, Marc J</creatorcontrib><creatorcontrib>Katz, Judith</creatorcontrib><creatorcontrib>Rothschild, Janice</creatorcontrib><creatorcontrib>Safaii, Homa</creatorcontrib><creatorcontrib>Supran, Stacey</creatorcontrib><title>The pancake phenomenon contributes to the inaccuracy of margin assessment in patients with breast cancer</title><title>The American journal of surgery</title><addtitle>Am J Surg</addtitle><description>Background: To determine the effect on margin evaluation for patients with breast cancer, we prospectively quantified the “flattening” of the breast specimen after surgical removal.
Methods: The volume and height of 100 consecutive breast biopsy specimens were recorded independently by the operating surgeon and the pathologist. Five factors were analyzed that were thought to contribute to changes in specimen dimensions: patient age, breast tissue density, mammographic lesion type, specimen size, and the use of compression during specimen radiography.
Results: After surgical removal, mean volume and height of the breast specimens decreased from 46 cm
3 to 29 cm
3 (30%) and from 2.6 cm to 1.4 cm (46%), respectively. Flattening of the breast specimens occurred in all subgroups studied.
Conclusions: Breast specimens are flattened after surgical removal, losing almost 50% of their original height. This “pancake” phenomenon has important implications for the accuracy of margin analysis.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Biopsy, Needle</subject><subject>Breast cancer</subject><subject>Breast Diseases - diagnostic imaging</subject><subject>Breast Diseases - pathology</subject><subject>Breast Diseases - surgery</subject><subject>Breast Neoplasms - diagnostic imaging</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - surgery</subject><subject>Culture Techniques</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Flattening</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Localization</subject><subject>Mammary gland diseases</subject><subject>Mammography</subject><subject>Mammography - methods</subject><subject>Margin assessment</subject><subject>Mastectomy</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness - pathology</subject><subject>Pathology</subject><subject>Patients</subject><subject>Probability</subject><subject>Prospective Studies</subject><subject>Radiation therapy</subject><subject>Radiography</subject><subject>Reference Values</subject><subject>Regression analysis</subject><subject>Sensitivity and Specificity</subject><subject>Specimen radiography</subject><subject>Subgroups</subject><subject>Surgeons</subject><subject>Surgery</subject><subject>Tumors</subject><subject>Variance analysis</subject><issn>0002-9610</issn><issn>1879-1883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkU1vFDEMhiMEotvCTwBFQiA4DMTzmZwqVJUPqRIHyjnKZBw2ZXeyxBlQ_z3e7opKXDhEjuXHr-zXQjwD9RYU9O--KqXqyvSgXqv6jVJmnz0QK9CDqUDr5qFY_UVOxCnRDacAbfNYnEANvWlasxLr6zXKnZu9-8FxjXPa8pulT3PJcVwKkixJFqbi7LxfsvO3MgW5dfl7nKUjQiLuKVxnoRL5S_J3LGs5ZnRUpGd1zE_Eo-A2hE-P8Ux8-3B5ffGpuvry8fPF-6vKt2BK5QH06PuhhuB4JeURTIu6N-Po9NirFhrf9Y0OZhwmU7sQlA4BTedMAJza5ky8Oujucvq5IBW7jeRxs3EzpoXsAEb3td6DL_4Bb9KSZ57Ncnlou64zDVPdgfI5EWUMdpcj735rQdn9IezdIezeZcvx7hDWcN_zo_oybnG67zo6z8DLI-DIu03I7FKke67hEc0wMHd-4JBN-xUxW_LssccpZvTFTin-Z5Q_xY6lnA</recordid><startdate>20020801</startdate><enddate>20020801</enddate><creator>Graham, Roger A</creator><creator>Homer, Marc J</creator><creator>Katz, Judith</creator><creator>Rothschild, Janice</creator><creator>Safaii, Homa</creator><creator>Supran, Stacey</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20020801</creationdate><title>The pancake phenomenon contributes to the inaccuracy of margin assessment in patients with breast cancer</title><author>Graham, Roger A ; Homer, Marc J ; Katz, Judith ; Rothschild, Janice ; Safaii, Homa ; Supran, Stacey</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-c118bc6721fa9020ce194e869bba8b60413c5638f9b7d92aff08ffe95a9f1ed43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Biopsy, Needle</topic><topic>Breast cancer</topic><topic>Breast Diseases - diagnostic imaging</topic><topic>Breast Diseases - pathology</topic><topic>Breast Diseases - surgery</topic><topic>Breast Neoplasms - diagnostic imaging</topic><topic>Breast Neoplasms - pathology</topic><topic>Breast Neoplasms - surgery</topic><topic>Culture Techniques</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Flattening</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Localization</topic><topic>Mammary gland diseases</topic><topic>Mammography</topic><topic>Mammography - methods</topic><topic>Margin assessment</topic><topic>Mastectomy</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness - pathology</topic><topic>Pathology</topic><topic>Patients</topic><topic>Probability</topic><topic>Prospective Studies</topic><topic>Radiation therapy</topic><topic>Radiography</topic><topic>Reference Values</topic><topic>Regression analysis</topic><topic>Sensitivity and Specificity</topic><topic>Specimen radiography</topic><topic>Subgroups</topic><topic>Surgeons</topic><topic>Surgery</topic><topic>Tumors</topic><topic>Variance analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Graham, Roger A</creatorcontrib><creatorcontrib>Homer, Marc J</creatorcontrib><creatorcontrib>Katz, Judith</creatorcontrib><creatorcontrib>Rothschild, Janice</creatorcontrib><creatorcontrib>Safaii, Homa</creatorcontrib><creatorcontrib>Supran, Stacey</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Graham, Roger A</au><au>Homer, Marc J</au><au>Katz, Judith</au><au>Rothschild, Janice</au><au>Safaii, Homa</au><au>Supran, Stacey</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The pancake phenomenon contributes to the inaccuracy of margin assessment in patients with breast cancer</atitle><jtitle>The American journal of surgery</jtitle><addtitle>Am J Surg</addtitle><date>2002-08-01</date><risdate>2002</risdate><volume>184</volume><issue>2</issue><spage>89</spage><epage>93</epage><pages>89-93</pages><issn>0002-9610</issn><eissn>1879-1883</eissn><coden>AJSUAB</coden><abstract>Background: To determine the effect on margin evaluation for patients with breast cancer, we prospectively quantified the “flattening” of the breast specimen after surgical removal.
Methods: The volume and height of 100 consecutive breast biopsy specimens were recorded independently by the operating surgeon and the pathologist. Five factors were analyzed that were thought to contribute to changes in specimen dimensions: patient age, breast tissue density, mammographic lesion type, specimen size, and the use of compression during specimen radiography.
Results: After surgical removal, mean volume and height of the breast specimens decreased from 46 cm
3 to 29 cm
3 (30%) and from 2.6 cm to 1.4 cm (46%), respectively. Flattening of the breast specimens occurred in all subgroups studied.
Conclusions: Breast specimens are flattened after surgical removal, losing almost 50% of their original height. This “pancake” phenomenon has important implications for the accuracy of margin analysis.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>12169349</pmid><doi>10.1016/S0002-9610(02)00902-9</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9610 |
| ispartof | The American journal of surgery, 2002-08, Vol.184 (2), p.89-93 |
| issn | 0002-9610 1879-1883 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71986284 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete; ProQuest Central UK/Ireland |
| subjects | Adult Aged Biological and medical sciences Biopsy Biopsy, Needle Breast cancer Breast Diseases - diagnostic imaging Breast Diseases - pathology Breast Diseases - surgery Breast Neoplasms - diagnostic imaging Breast Neoplasms - pathology Breast Neoplasms - surgery Culture Techniques Diagnosis, Differential Female Flattening Gynecology. Andrology. Obstetrics Humans Immunohistochemistry Localization Mammary gland diseases Mammography Mammography - methods Margin assessment Mastectomy Medical sciences Middle Aged Neoplasm Invasiveness - pathology Pathology Patients Probability Prospective Studies Radiation therapy Radiography Reference Values Regression analysis Sensitivity and Specificity Specimen radiography Subgroups Surgeons Surgery Tumors Variance analysis |
| title | The pancake phenomenon contributes to the inaccuracy of margin assessment in patients with breast cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T14%3A51%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20pancake%20phenomenon%20contributes%20to%20the%20inaccuracy%20of%20margin%20assessment%20in%20patients%20with%20breast%20cancer&rft.jtitle=The%20American%20journal%20of%20surgery&rft.au=Graham,%20Roger%20A&rft.date=2002-08-01&rft.volume=184&rft.issue=2&rft.spage=89&rft.epage=93&rft.pages=89-93&rft.issn=0002-9610&rft.eissn=1879-1883&rft.coden=AJSUAB&rft_id=info:doi/10.1016/S0002-9610(02)00902-9&rft_dat=%3Cproquest_cross%3E2847455593%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2847455593&rft_id=info:pmid/12169349&rft_els_id=S0002961002009029&rfr_iscdi=true |