Tumour necrosis factor alpha stimulates nitric oxide production more potently than interleukin-1beta in porcine articular chondrocytes

To compare the time- and concentration-dependent effects of tumour necrosis factor alpha (TNF-alpha) and interleukin 1beta (IL-1beta) on the induction of nitric oxide synthase (NOS), the production of nitric oxide (NO) and the expression of aggrecan and hyaluronan (HA) in chondrocytes. Primary porci...

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Veröffentlicht in:	Rheumatology (Oxford, England) England), 2002-08, Vol.41 (8), p.883-891
Hauptverfasser:	Goodstone, N J, Hardingham, T E
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - genetics Aggrecans Animals Cartilage, Articular - drug effects Cartilage, Articular - physiology Cells, Cultured Chondrocytes - drug effects Chondrocytes - physiology DNA Primers Extracellular Matrix Proteins Humans Hyaluronic Acid - biosynthesis Interleukin-1 - pharmacology Kinetics Lectins, C-Type Nitric Oxide - biosynthesis Nitric Oxide Synthase - genetics Nitric Oxide Synthase Type II Nitrites - metabolism Proteoglycans - biosynthesis ras Proteins - genetics Recombinant Proteins - pharmacology Reverse Transcriptase Polymerase Chain Reaction Swine Tumor Necrosis Factor-alpha - pharmacology
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