alpha(1C) (Ca(V)1.2) L-type calcium channel mediates mechanosensitive calcium regulation

Smooth muscle exhibits mechanosensitivity independent of neural input, suggesting that mechanosensitive pathways reside within smooth muscle cells. The native L-type calcium current recorded from human intestinal smooth muscle is modulated by stretch. To define mechanosensitive mechanisms involved i...

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2002-09, Vol.283 (3), p.C1001-C1008
Hauptverfasser:	Lyford, Greg L, Strege, Peter R, Shepard, Allan, Ou, Yijun, Ermilov, Leonid, Miller, Steven M, Gibbons, Simon J, Rae, James L, Szurszewski, Joseph H, Farrugia, Gianrico
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium Channels, L-Type - biosynthesis Calcium Channels, L-Type - drug effects Calcium Channels, L-Type - genetics Cell Line CHO Cells Cloning, Molecular Cricetinae Enzyme Inhibitors - pharmacology Humans Ion Channel Gating - drug effects Jejunum - metabolism Kidney - cytology Kidney - metabolism Membrane Potentials - drug effects Membrane Potentials - physiology Molecular Sequence Data Organ Specificity - physiology Patch-Clamp Techniques Pressure Protein Isoforms - biosynthesis Protein Isoforms - drug effects Protein Isoforms - genetics Protein Structure, Tertiary - physiology Protein Subunits Sequence Deletion Signal Transduction - drug effects Signal Transduction - physiology Space life sciences Stress, Mechanical Transfection
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