Isoflavones regulate interleukin-6 and osteoprotegerin synthesis during osteoblast cell differentiation via an estrogen-receptor-dependent pathway

Isoflavones regulate interleukin-6 and osteoprotegerin synthesis during osteoblast cell differentiation via an estrogen-receptor-dependent pathway

The hypothesis tested in this in vitro study was that the expression and production of dietary isoflavone-mediated osteoclastogenesis-regulatory cytokines, such as interleukin-6 (IL-6) and osteoprotegerin (OPG), are related to the different levels of estrogen receptors expressed in two hFOB osteobla...

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Veröffentlicht in:Biochemical and biophysical research communications 2002-07, Vol.295 (2), p.417-422
Hauptverfasser: Chen, X.W, Garner, S.C, Anderson, J.J.B
Format: Artikel
Sprache:eng
Schlagworte:
Cell Differentiation
Estrogen receptors
Glycoproteins - biosynthesis
Glycoproteins - genetics
hFOB
Humans
Interleukin-6
Interleukin-6 - biosynthesis
Interleukin-6 - genetics
Isoflavones
Isoflavones - pharmacology
Osteoblasts
Osteoclastogenesis
Osteoprotegerin
Receptors, Cytoplasmic and Nuclear - biosynthesis
Receptors, Cytoplasmic and Nuclear - genetics
Receptors, Estrogen - physiology
Receptors, Tumor Necrosis Factor
RNA, Messenger - genetics
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Zusammenfassung:The hypothesis tested in this in vitro study was that the expression and production of dietary isoflavone-mediated osteoclastogenesis-regulatory cytokines, such as interleukin-6 (IL-6) and osteoprotegerin (OPG), are related to the different levels of estrogen receptors expressed in two hFOB osteoblastic cell lines. OPG mRNA expression was significantly increased in both hFOB1.19 and hFOB/ER9 cells treated with 17β-estradiol, genistein, or daidzein at 10 −8 M in comparison to vehicle (control) ( P
ISSN:0006-291X
1090-2104
DOI:10.1016/S0006-291X(02)00667-8