Adaptor Protein Shc Is an Isoform-specific Direct Activator of the Tyrosine Kinase c-Src

The activity of c-Src protein-tyrosine kinase is up-regulated under a number of receptor signaling pathways. However, the activation mechanism of c-Src under physiological conditions has remained unclear. We show here that the Shc adaptor protein is a novel direct activator of c-Src in epidermal gro...

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Veröffentlicht in:	The Journal of biological chemistry 2002-08, Vol.277 (33), p.29568-29576
Hauptverfasser:	Sato, Ken-ichi, Nagao, Tomomi, Kakumoto, Miki, Kimoto, Miwa, Otsuki, Tetsuji, Iwasaki, Tetsushi, Tokmakov, Alexander A., Owada, Koji, Fukami, Yasuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Adaptor Proteins, Vesicular Transport Amino Acid Sequence Animals Apoptosis Cell Cycle Cell Line Cyclin-Dependent Kinase Inhibitor p21 Cyclins - metabolism Enzyme Activators - metabolism Humans Molecular Sequence Data Phosphorylation Point Mutation Protein Binding Proteins - genetics Proteins - metabolism Proto-Oncogene Proteins pp60(c-src) - metabolism Shc Signaling Adaptor Proteins Src Homology 2 Domain-Containing, Transforming Protein 1 Tyrosine - metabolism
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