Impaired Sphingomyelinase Activity and Epidermal Differentiation in Atopic Dermatitis

A defective permeability barrier leads to the penetration of environmental allergens into the skin and initiates immunological reactions and inflammation crucially involved in the pathogenesis of atopic dermatitis (AD). Decreased stratum corneum ceramide content may cause the defect in permeability...

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Veröffentlicht in:	Journal of investigative dermatology 2004-06, Vol.122 (6), p.1423-1431
Hauptverfasser:	Jensen, Jens-Michael, Fölster-Holst, Regina, Baranowsky, Anke, Schunck, Michael, Winoto-Morbach, Supandi, Neumann, Claudia, Schütze, Stefan, Proksch, Ehrhardt
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergic diseases atopic dermatitis Biological and medical sciences Biomarkers Blotting, Western Cell Differentiation - physiology Cell Division - physiology Ceramides - metabolism Dermatitis, Atopic - metabolism Dermatitis, Atopic - pathology Epidermis - enzymology Epidermis - pathology Female filaggrin Humans Immunopathology Intermediate Filament Proteins - metabolism involucrin keratin Keratins - metabolism loricrin Male Medical sciences Membrane Proteins - metabolism Protein Precursors - metabolism Signal Transduction - physiology Skin allergic diseases. Stinging insect allergies Sphingomyelin Phosphodiesterase - metabolism sphingomyelinase Substrate Specificity Water - metabolism
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