Severe manifestation of acute hepatitis A recently found in Gunma, Japan
The incidence of acute hepatitis A infection in Japan peaked 10 years ago and has been decreasing since then. However, an increase in severe cases of the disease has been documented recently. We experienced an outbreak in 1998-1999, and compared the clinical features of the disease in 1998-1999 (rec...
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| Veröffentlicht in: | Journal of gastroenterology 2002-07, Vol.37 (7), p.517-522 |
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| creator | Kanda, Daisuke Takagi, Hitoshi Hashimoto, Yoshiaki Yamazaki, Yuichi Matsui, Masayuki Kosone, Takashi Arai, Hirotaka Ichikawa, Takeshi Nakajima, Hiroaki Otsuka, Toshiyuki Kojima, Akira Sato, Ken Kakizaki, Satoru Matsuzaki, Yutaka Matsumoto, Tatsuhiko Shimoda, Ryuya Kaneko, Mieko Takayama, Hisashi Takahashi, Hitomi Abe, Takehiko Takezawa, Jiro Mori, Masatomo |
| description | The incidence of acute hepatitis A infection in Japan peaked 10 years ago and has been decreasing since then. However, an increase in severe cases of the disease has been documented recently. We experienced an outbreak in 1998-1999, and compared the clinical features of the disease in 1998-1999 (recent outbreak) and in 1987-1988 (past outbreak) in our prefecture (Gunma).
Forty patients with acute hepatitis A were admitted to nine Gunma hospitals from October 1998 to September 1999. Their clinical features were compared with those of 100 patients with acute hepatitis A admitted to the same hospitals in 1987-1988.
Both outbreaks occurred mostly during the winter-spring season. Secondary familial infection was significantly decreased in the recent outbreak. Patients in the recent outbreak were 7 years older than those in the past outbreak. Laboratory findings, such as serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels and prothrombin time, were worse in the recent than in the past outbreak. Severe-type hepatitis and fulminant hepatitis occurred in 5 patients (12.5%) in the recent outbreak but in only 2 patients (2.0%) in the past outbreak.
Clinical data and manifestations were more severe in the recent outbreak than in the past outbreak of acute hepatitis A. It is important to be aware of hepatitis A virus infection and to take into account the available vaccination against hepatitis A virus in Japan. |
| doi_str_mv | 10.1007/s005350200080 |
| format | Article |
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Forty patients with acute hepatitis A were admitted to nine Gunma hospitals from October 1998 to September 1999. Their clinical features were compared with those of 100 patients with acute hepatitis A admitted to the same hospitals in 1987-1988.
Both outbreaks occurred mostly during the winter-spring season. Secondary familial infection was significantly decreased in the recent outbreak. Patients in the recent outbreak were 7 years older than those in the past outbreak. Laboratory findings, such as serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels and prothrombin time, were worse in the recent than in the past outbreak. Severe-type hepatitis and fulminant hepatitis occurred in 5 patients (12.5%) in the recent outbreak but in only 2 patients (2.0%) in the past outbreak.
Clinical data and manifestations were more severe in the recent outbreak than in the past outbreak of acute hepatitis A. It is important to be aware of hepatitis A virus infection and to take into account the available vaccination against hepatitis A virus in Japan.</description><identifier>ISSN: 0944-1174</identifier><identifier>EISSN: 1435-5922</identifier><identifier>DOI: 10.1007/s005350200080</identifier><identifier>PMID: 12162409</identifier><language>eng</language><publisher>Japan: Springer Nature B.V</publisher><subject>Acute Disease ; Adult ; Alanine Transaminase - blood ; Animals ; Aspartate Aminotransferases - blood ; Disease Outbreaks ; Female ; Hepatitis A - diagnosis ; Hepatitis A - epidemiology ; Humans ; Incidence ; Japan - epidemiology ; Liver Failure - virology ; Male ; Ostreidae - virology ; Prothrombin Time ; Shellfish - virology</subject><ispartof>Journal of gastroenterology, 2002-07, Vol.37 (7), p.517-522</ispartof><rights>Springer-Verlag Tokyo 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c301t-2453916d4ba750cf1fe00c7c1dcccf78047e1d82bfce98592e6c2c0a33987c8e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12162409$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kanda, Daisuke</creatorcontrib><creatorcontrib>Takagi, Hitoshi</creatorcontrib><creatorcontrib>Hashimoto, Yoshiaki</creatorcontrib><creatorcontrib>Yamazaki, Yuichi</creatorcontrib><creatorcontrib>Matsui, Masayuki</creatorcontrib><creatorcontrib>Kosone, Takashi</creatorcontrib><creatorcontrib>Arai, Hirotaka</creatorcontrib><creatorcontrib>Ichikawa, Takeshi</creatorcontrib><creatorcontrib>Nakajima, Hiroaki</creatorcontrib><creatorcontrib>Otsuka, Toshiyuki</creatorcontrib><creatorcontrib>Kojima, Akira</creatorcontrib><creatorcontrib>Sato, Ken</creatorcontrib><creatorcontrib>Kakizaki, Satoru</creatorcontrib><creatorcontrib>Matsuzaki, Yutaka</creatorcontrib><creatorcontrib>Matsumoto, Tatsuhiko</creatorcontrib><creatorcontrib>Shimoda, Ryuya</creatorcontrib><creatorcontrib>Kaneko, Mieko</creatorcontrib><creatorcontrib>Takayama, Hisashi</creatorcontrib><creatorcontrib>Takahashi, Hitomi</creatorcontrib><creatorcontrib>Abe, Takehiko</creatorcontrib><creatorcontrib>Takezawa, Jiro</creatorcontrib><creatorcontrib>Mori, Masatomo</creatorcontrib><title>Severe manifestation of acute hepatitis A recently found in Gunma, Japan</title><title>Journal of gastroenterology</title><addtitle>J Gastroenterol</addtitle><description>The incidence of acute hepatitis A infection in Japan peaked 10 years ago and has been decreasing since then. However, an increase in severe cases of the disease has been documented recently. We experienced an outbreak in 1998-1999, and compared the clinical features of the disease in 1998-1999 (recent outbreak) and in 1987-1988 (past outbreak) in our prefecture (Gunma).
Forty patients with acute hepatitis A were admitted to nine Gunma hospitals from October 1998 to September 1999. Their clinical features were compared with those of 100 patients with acute hepatitis A admitted to the same hospitals in 1987-1988.
Both outbreaks occurred mostly during the winter-spring season. Secondary familial infection was significantly decreased in the recent outbreak. Patients in the recent outbreak were 7 years older than those in the past outbreak. Laboratory findings, such as serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels and prothrombin time, were worse in the recent than in the past outbreak. Severe-type hepatitis and fulminant hepatitis occurred in 5 patients (12.5%) in the recent outbreak but in only 2 patients (2.0%) in the past outbreak.
Clinical data and manifestations were more severe in the recent outbreak than in the past outbreak of acute hepatitis A. It is important to be aware of hepatitis A virus infection and to take into account the available vaccination against hepatitis A virus in Japan.</description><subject>Acute Disease</subject><subject>Adult</subject><subject>Alanine Transaminase - blood</subject><subject>Animals</subject><subject>Aspartate Aminotransferases - blood</subject><subject>Disease Outbreaks</subject><subject>Female</subject><subject>Hepatitis A - diagnosis</subject><subject>Hepatitis A - epidemiology</subject><subject>Humans</subject><subject>Incidence</subject><subject>Japan - epidemiology</subject><subject>Liver Failure - virology</subject><subject>Male</subject><subject>Ostreidae - virology</subject><subject>Prothrombin Time</subject><subject>Shellfish - virology</subject><issn>0944-1174</issn><issn>1435-5922</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkEFLw0AQhRdRbK0evcriwZPRmd0kuzmWolUpeFDPYbuZxZRkE7OJ0H9vSguip4HHx-PNx9glwh0CqPsAkMgEBABoOGJTjGUSJZkQx2wKWRxHiCqesLMQNgAoIdGnbIICUxFDNmVPb_RNHfHa-NJR6E1fNp43jhs79MQ_qR2Tvgx8zjuy5Ptqy10z-IKXni8HX5tb_mJa48_ZiTNVoIvDnbGPx4f3xVO0el0-L-aryErAPhJxIjNMi3htVALWoSMAqywW1lqnNMSKsNBi7SxlevyDUissGCkzrawmOWM3-962a76GcXFel8FSVRlPzRByhZmWKhUjeP0P3DRD58dtuUCFSiZ6B0V7yHZNCB25vO3K2nTbHCHf-c3_-B35q0PpsK6p-KUPQuUPTj9z0g</recordid><startdate>20020701</startdate><enddate>20020701</enddate><creator>Kanda, Daisuke</creator><creator>Takagi, Hitoshi</creator><creator>Hashimoto, Yoshiaki</creator><creator>Yamazaki, Yuichi</creator><creator>Matsui, Masayuki</creator><creator>Kosone, Takashi</creator><creator>Arai, Hirotaka</creator><creator>Ichikawa, Takeshi</creator><creator>Nakajima, Hiroaki</creator><creator>Otsuka, Toshiyuki</creator><creator>Kojima, Akira</creator><creator>Sato, Ken</creator><creator>Kakizaki, Satoru</creator><creator>Matsuzaki, Yutaka</creator><creator>Matsumoto, Tatsuhiko</creator><creator>Shimoda, Ryuya</creator><creator>Kaneko, Mieko</creator><creator>Takayama, Hisashi</creator><creator>Takahashi, Hitomi</creator><creator>Abe, Takehiko</creator><creator>Takezawa, Jiro</creator><creator>Mori, Masatomo</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>20020701</creationdate><title>Severe manifestation of acute hepatitis A recently found in Gunma, Japan</title><author>Kanda, Daisuke ; Takagi, Hitoshi ; Hashimoto, Yoshiaki ; Yamazaki, Yuichi ; Matsui, Masayuki ; Kosone, Takashi ; Arai, Hirotaka ; Ichikawa, Takeshi ; Nakajima, Hiroaki ; Otsuka, Toshiyuki ; Kojima, Akira ; Sato, Ken ; Kakizaki, Satoru ; Matsuzaki, Yutaka ; Matsumoto, Tatsuhiko ; Shimoda, Ryuya ; Kaneko, Mieko ; Takayama, Hisashi ; Takahashi, Hitomi ; Abe, Takehiko ; Takezawa, Jiro ; Mori, Masatomo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c301t-2453916d4ba750cf1fe00c7c1dcccf78047e1d82bfce98592e6c2c0a33987c8e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Acute Disease</topic><topic>Adult</topic><topic>Alanine Transaminase - 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Academic</collection><collection>ComDisDome</collection><jtitle>Journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kanda, Daisuke</au><au>Takagi, Hitoshi</au><au>Hashimoto, Yoshiaki</au><au>Yamazaki, Yuichi</au><au>Matsui, Masayuki</au><au>Kosone, Takashi</au><au>Arai, Hirotaka</au><au>Ichikawa, Takeshi</au><au>Nakajima, Hiroaki</au><au>Otsuka, Toshiyuki</au><au>Kojima, Akira</au><au>Sato, Ken</au><au>Kakizaki, Satoru</au><au>Matsuzaki, Yutaka</au><au>Matsumoto, Tatsuhiko</au><au>Shimoda, Ryuya</au><au>Kaneko, Mieko</au><au>Takayama, Hisashi</au><au>Takahashi, Hitomi</au><au>Abe, Takehiko</au><au>Takezawa, Jiro</au><au>Mori, Masatomo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Severe manifestation of acute hepatitis A recently found in Gunma, Japan</atitle><jtitle>Journal of gastroenterology</jtitle><addtitle>J Gastroenterol</addtitle><date>2002-07-01</date><risdate>2002</risdate><volume>37</volume><issue>7</issue><spage>517</spage><epage>522</epage><pages>517-522</pages><issn>0944-1174</issn><eissn>1435-5922</eissn><abstract>The incidence of acute hepatitis A infection in Japan peaked 10 years ago and has been decreasing since then. However, an increase in severe cases of the disease has been documented recently. We experienced an outbreak in 1998-1999, and compared the clinical features of the disease in 1998-1999 (recent outbreak) and in 1987-1988 (past outbreak) in our prefecture (Gunma).
Forty patients with acute hepatitis A were admitted to nine Gunma hospitals from October 1998 to September 1999. Their clinical features were compared with those of 100 patients with acute hepatitis A admitted to the same hospitals in 1987-1988.
Both outbreaks occurred mostly during the winter-spring season. Secondary familial infection was significantly decreased in the recent outbreak. Patients in the recent outbreak were 7 years older than those in the past outbreak. Laboratory findings, such as serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels and prothrombin time, were worse in the recent than in the past outbreak. Severe-type hepatitis and fulminant hepatitis occurred in 5 patients (12.5%) in the recent outbreak but in only 2 patients (2.0%) in the past outbreak.
Clinical data and manifestations were more severe in the recent outbreak than in the past outbreak of acute hepatitis A. It is important to be aware of hepatitis A virus infection and to take into account the available vaccination against hepatitis A virus in Japan.</abstract><cop>Japan</cop><pub>Springer Nature B.V</pub><pmid>12162409</pmid><doi>10.1007/s005350200080</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of gastroenterology, 2002-07, Vol.37 (7), p.517-522 |
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| subjects | Acute Disease Adult Alanine Transaminase - blood Animals Aspartate Aminotransferases - blood Disease Outbreaks Female Hepatitis A - diagnosis Hepatitis A - epidemiology Humans Incidence Japan - epidemiology Liver Failure - virology Male Ostreidae - virology Prothrombin Time Shellfish - virology |
| title | Severe manifestation of acute hepatitis A recently found in Gunma, Japan |
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