Morphometric study of the spleen in chronic Chagas' disease
There is frequently an increase in spleen size in infectious systemic and chronic venous congestion. The aim of this report was to perform a comparative study of the spleen tissue of chagasic or nonchagasic autopsied patients with or without congestive heart failure. Evaluations were made of 111 cas...
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| Veröffentlicht in: | The American journal of tropical medicine and hygiene 2002-04, Vol.66 (4), p.401-403 |
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| container_title | The American journal of tropical medicine and hygiene |
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| creator | Pereira, SA Rodrigues, DB Castro, EC dos Reis, MA Teixeira Vde, P |
| description | There is frequently an increase in spleen size in infectious systemic and chronic venous congestion. The aim of this report was to perform a comparative study of the spleen tissue of chagasic or nonchagasic autopsied patients with or without congestive heart failure. Evaluations were made of 111 cases. Connective tissue intensity, follicular density and area, and follicular arterioles wall area were determined through the morphometric study. The connective tissue was similar in all groups. The density of the lymphoid follicles was significantly less among the chagasic cases (P = 0.032). The follicular area was larger among the chagasic cases and in the chagasic group with congestive heart failure. The chagasic group without congestive heart failure presented a greater area of follicular arteriole walls. Therefore, the spleen modifications in chronic Chagas' disease could be a consequence not only of the heart failure but also of the Chagas infection itself. |
| doi_str_mv | 10.4269/ajtmh.2002.66.401 |
| format | Article |
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The aim of this report was to perform a comparative study of the spleen tissue of chagasic or nonchagasic autopsied patients with or without congestive heart failure. Evaluations were made of 111 cases. Connective tissue intensity, follicular density and area, and follicular arterioles wall area were determined through the morphometric study. The connective tissue was similar in all groups. The density of the lymphoid follicles was significantly less among the chagasic cases (P = 0.032). The follicular area was larger among the chagasic cases and in the chagasic group with congestive heart failure. The chagasic group without congestive heart failure presented a greater area of follicular arteriole walls. 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The aim of this report was to perform a comparative study of the spleen tissue of chagasic or nonchagasic autopsied patients with or without congestive heart failure. Evaluations were made of 111 cases. Connective tissue intensity, follicular density and area, and follicular arterioles wall area were determined through the morphometric study. The connective tissue was similar in all groups. The density of the lymphoid follicles was significantly less among the chagasic cases (P = 0.032). The follicular area was larger among the chagasic cases and in the chagasic group with congestive heart failure. The chagasic group without congestive heart failure presented a greater area of follicular arteriole walls. Therefore, the spleen modifications in chronic Chagas' disease could be a consequence not only of the heart failure but also of the Chagas infection itself.</description><subject>Autopsy</subject><subject>Biological and medical sciences</subject><subject>Chagas Cardiomyopathy - pathology</subject><subject>Chagas Disease - pathology</subject><subject>Heart Failure - pathology</subject><subject>Human protozoal diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Organ Size</subject><subject>Parasitic diseases</subject><subject>Protozoal diseases</subject><subject>Retrospective Studies</subject><subject>Spleen - pathology</subject><subject>Trypanosomiasis</subject><issn>0002-9637</issn><issn>1476-1645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOwzAQRS0EglL4ADYoG2CV4InjR8QKVbykIjawthzXaVLlhZ0o6t_jtpG6ZDWLOfeO5iB0AzhKYpY-qk1fF1GMcRwxFiUYTtAMEs5CYAk9RTPsN2HKCL9Al85tMAYRA5yjC4g9Ead0hp4-W9sVbW16W-rA9cNqG7R50BcmcF1lTBOUTaAL2zZ-vSjUWrmHYFU6o5y5Qme5qpy5nuYc_by-fC_ew-XX28fieRnqhEAfai6INhywULlmNEsykjOOOcWA04xjggnJtKZCCCoUI7kSOvEPKIJ1RnlG5uj-0NvZ9ncwrpd16bSpKtWYdnCSQyoIp-JfEARjwDH1IBxAbVvnrMllZ8ta2a0ELHdq5V6t3KmVjEmv1mdup_Ihq83qmJhceuBuApTTqsqtanTpjhwRMaEJHLmiXBdjaY10taoqXwtyHMfduf3BP7sRjaI</recordid><startdate>20020401</startdate><enddate>20020401</enddate><creator>Pereira, SA</creator><creator>Rodrigues, DB</creator><creator>Castro, EC</creator><creator>dos Reis, MA</creator><creator>Teixeira Vde, P</creator><general>ASTMH</general><general>Allen Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>20020401</creationdate><title>Morphometric study of the spleen in chronic Chagas' disease</title><author>Pereira, SA ; Rodrigues, DB ; Castro, EC ; dos Reis, MA ; Teixeira Vde, P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-c783ce7108afc65b4b3f670750109b703033bcc588858a63fa8c4645a30cb57b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Autopsy</topic><topic>Biological and medical sciences</topic><topic>Chagas Cardiomyopathy - pathology</topic><topic>Chagas Disease - pathology</topic><topic>Heart Failure - pathology</topic><topic>Human protozoal diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Organ Size</topic><topic>Parasitic diseases</topic><topic>Protozoal diseases</topic><topic>Retrospective Studies</topic><topic>Spleen - pathology</topic><topic>Trypanosomiasis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pereira, SA</creatorcontrib><creatorcontrib>Rodrigues, DB</creatorcontrib><creatorcontrib>Castro, EC</creatorcontrib><creatorcontrib>dos Reis, MA</creatorcontrib><creatorcontrib>Teixeira Vde, P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of tropical medicine and hygiene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pereira, SA</au><au>Rodrigues, DB</au><au>Castro, EC</au><au>dos Reis, MA</au><au>Teixeira Vde, P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Morphometric study of the spleen in chronic Chagas' disease</atitle><jtitle>The American journal of tropical medicine and hygiene</jtitle><addtitle>Am J Trop Med Hyg</addtitle><date>2002-04-01</date><risdate>2002</risdate><volume>66</volume><issue>4</issue><spage>401</spage><epage>403</epage><pages>401-403</pages><issn>0002-9637</issn><eissn>1476-1645</eissn><coden>AJTHAB</coden><abstract>There is frequently an increase in spleen size in infectious systemic and chronic venous congestion. The aim of this report was to perform a comparative study of the spleen tissue of chagasic or nonchagasic autopsied patients with or without congestive heart failure. Evaluations were made of 111 cases. Connective tissue intensity, follicular density and area, and follicular arterioles wall area were determined through the morphometric study. The connective tissue was similar in all groups. The density of the lymphoid follicles was significantly less among the chagasic cases (P = 0.032). The follicular area was larger among the chagasic cases and in the chagasic group with congestive heart failure. The chagasic group without congestive heart failure presented a greater area of follicular arteriole walls. Therefore, the spleen modifications in chronic Chagas' disease could be a consequence not only of the heart failure but also of the Chagas infection itself.</abstract><cop>Lawrence, KS</cop><pub>ASTMH</pub><pmid>12164295</pmid><doi>10.4269/ajtmh.2002.66.401</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Autopsy Biological and medical sciences Chagas Cardiomyopathy - pathology Chagas Disease - pathology Heart Failure - pathology Human protozoal diseases Humans Infectious diseases Medical sciences Organ Size Parasitic diseases Protozoal diseases Retrospective Studies Spleen - pathology Trypanosomiasis |
| title | Morphometric study of the spleen in chronic Chagas' disease |
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