Developmental regulation of neuronal K(Ca) channels by TGFbeta1: an essential role for PI3 kinase signaling and membrane insertion

TGFbeta1 is a target-derived factor responsible for the developmental expression of large-conductance Ca(2+)-activated K(+) (K(Ca)) channels in ciliary neurons of the chick ciliary ganglion. The acute effects of TGFbeta1 on K(Ca) channels are mediated by posttranslational events and require activati...

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Veröffentlicht in:	Journal of neurophysiology 2002-08, Vol.88 (2), p.954-964
Hauptverfasser:	Lhuillier, Loic, Dryer, Stuart E
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Phosphoinositide-Dependent Protein Kinases Androstadienes - pharmacology Animals Cell Culture Techniques Chick Embryo Chromones - pharmacology Electrophysiology Enzyme Inhibitors - pharmacology Flavonoids - pharmacology Immunoblotting Immunohistochemistry Large-Conductance Calcium-Activated Potassium Channels MAP Kinase Kinase 1 Mitogen-Activated Protein Kinase Kinases - metabolism Mitogen-Activated Protein Kinases - metabolism Morpholines - pharmacology Neurons - metabolism Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - metabolism Potassium Channels, Calcium-Activated - drug effects Potassium Channels, Calcium-Activated - metabolism Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt Signal Transduction - drug effects Transforming Growth Factor beta - metabolism
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