Synthesis of cholesterol–carborane conjugate for targeted drug delivery

The cholesterol–carborane conjugate has been designed and synthesized to selectively deliver boron to tumor cells by means of reconstituted low-density lipoprotein. The chemical stability and cytotoxicity of the new compound have been examined. Several methods have been evaluated for incorporation o...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2002-09, Vol.12 (17), p.2455-2458
Hauptverfasser:	Ji, Bingqing, Peacock, Gina, Lu, D.Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacology Biological and medical sciences Boron Compounds - administration & dosage Boron Compounds - pharmacology Boron Neutron Capture Therapy - methods Cell Death - drug effects Cholesterol - administration & dosage Cholesterol - pharmacology Drug Delivery Systems Drug Stability Humans Hydrogen-Ion Concentration Lipoproteins, LDL Liposomes Medical sciences Radiation therapy and radiosensitizing agent Treatment with physical agents Treatment. General aspects Tumor Cells, Cultured Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!