Synthesis of cholesterol–carborane conjugate for targeted drug delivery

The cholesterol–carborane conjugate has been designed and synthesized to selectively deliver boron to tumor cells by means of reconstituted low-density lipoprotein. The chemical stability and cytotoxicity of the new compound have been examined. Several methods have been evaluated for incorporation o...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2002-09, Vol.12 (17), p.2455-2458
Hauptverfasser:	Ji, Bingqing, Peacock, Gina, Lu, D.Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacology Biological and medical sciences Boron Compounds - administration & dosage Boron Compounds - pharmacology Boron Neutron Capture Therapy - methods Cell Death - drug effects Cholesterol - administration & dosage Cholesterol - pharmacology Drug Delivery Systems Drug Stability Humans Hydrogen-Ion Concentration Lipoproteins, LDL Liposomes Medical sciences Radiation therapy and radiosensitizing agent Treatment with physical agents Treatment. General aspects Tumor Cells, Cultured Tumors
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Beschreibung
Zusammenfassung:	The cholesterol–carborane conjugate has been designed and synthesized to selectively deliver boron to tumor cells by means of reconstituted low-density lipoprotein. The chemical stability and cytotoxicity of the new compound have been examined. Several methods have been evaluated for incorporation of the compound into LDL. Graphic
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(02)00426-2