Effect of inhibition of inducible nitric oxide synthase and guanylyl cyclase on endotoxin-induced delay in gastric emptying and intestinal transit in mice

Nitric oxide (NO) is postulated to play a role in endotoxin-induced ileus. We investigated the effect of selective blockade of inducible NO synthase (iNOS) and guanylyl cyclase on endotoxin-induced ileus in mice. Thirty minutes before injection of lipopolysaccharides (LPS), mice were pretreated with...

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Veröffentlicht in:	Shock (Augusta, Ga.) Ga.), 2002-08, Vol.18 (2), p.125-131
Hauptverfasser:	DE WINTER, Benedicte Y, BREDENOORD, Albert J, DE MAN, Joris G, MOREELS, Tom G, HERMAN, Arnold G, PELCKMANS, Paul A
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Dexamethasone - pharmacology Disease Models, Animal Emergency and intensive care: infection, septic shock Endotoxins Female Gastric Emptying - drug effects Gastric Emptying - physiology Gastrointestinal Transit - drug effects Gastrointestinal Transit - physiology Guanylate Cyclase - drug effects Guanylate Cyclase - metabolism Intensive care medicine Intestinal Obstruction - enzymology Intestinal Obstruction - physiopathology Male Medical sciences Mice NG-Nitroarginine Methyl Ester - pharmacology Nitric Oxide Synthase - drug effects Nitric Oxide Synthase - metabolism Reference Values Sensitivity and Specificity
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