Gene Knockout of Glycine Transporter 1: Characterization of the Behavioral Phenotype

N-methyl-D-aspartate receptor (NMDAR) activation requires both the binding of glutamate to its recognition site and occupancy of the strychnine insensitive glycine modulatory site (GMS). Pharmacological studies suggest that the glycine transporter, GlyT1, maintains subsaturating concentrations of gl...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2004-06, Vol.101 (22), p.8485-8490
Hauptverfasser:	Tsai, Guochuan, Ralph-Williams, Rebecca J., Martina, Marzia, Bergeron, Richard, Berger-Sweeney, Joanne, Dunham, Kevin S., Jiang, Zhichun, Caine, S. Barak, Coyle, Joseph T., Scolnick, Edward M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Transport Systems, Neutral - genetics Amino Acid Transport Systems, Neutral - metabolism Amino acids Amphetamines - pharmacology Animals Behavior, Animal - physiology Biological Sciences Central Nervous System Stimulants - pharmacology Dizocilpine Maleate - pharmacology Excitatory Amino Acid Antagonists - pharmacology Exons Gene Targeting Genetically modified organisms Genetics Genotypes Glycine - metabolism Glycine Plasma Membrane Transport Proteins Hippocampus - cytology Hippocampus - drug effects Hippocampus - metabolism In Vitro Techniques Locomotion Memory Mice Mice, Inbred C57BL Mice, Knockout Motor Activity - physiology Neurology Patch-Clamp Techniques Phenotype Polymerase chain reaction Prosencephalon - chemistry Prosencephalon - metabolism Pyramidal cells Receptors, N-Methyl-D-Aspartate - metabolism Rodents Serine - metabolism Sodium - metabolism Synapses Synapses - physiology
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