Effects of cis-resveratrol on inflammatory murine macrophages: antioxidant activity and down-regulation of inflammatory genes

This study investigated for the first time the effects of the cis isomer of resveratrol (c‐RESV) on the responses of inflammatory murine peritoneal macrophages, namely on the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) during the respiratory burst; on the biosynth...

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Veröffentlicht in:	Journal of leukocyte biology 2004-06, Vol.75 (6), p.1156-1165
Hauptverfasser:	Leiro, José, Álvarez, Ezequiel, Arranz, Juan A., Laguna, Reyes, Uriarte, Eugenio, Orallo, Francisco
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Antioxidants - pharmacology Cyclooxygenase 2 Dinoprostone - metabolism Down-Regulation Hypoxanthine - metabolism inducible nitric oxide synthase Interferon-gamma - pharmacology Isoenzymes - metabolism Lipopolysaccharides - pharmacology Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - metabolism Mice Mice, Inbred BALB C Multienzyme Complexes - antagonists & inhibitors NADH, NADPH Oxidoreductases - antagonists & inhibitors NADH/NADPH oxidase NADPH Oxidases - antagonists & inhibitors nitric oxide Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type II prostaglandin E2 Prostaglandin-Endoperoxide Synthases - metabolism Rats Rats, Wistar Reactive Nitrogen Species - metabolism Reactive Oxygen Species - metabolism Respiratory Burst - drug effects Stilbenes - pharmacology xanthine oxidase Xanthine Oxidase - metabolism
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