Single nucleotide polymorphisms of thrifty genes for energy metabolism: evolutionary origins and prospects for intervention to prevent obesity-related diseases

The “thrifty” genotype and phenotype that save energy are detrimental to the health of people living in affluent societies. Individual differences in energy metabolism are caused primarily by single nucleotide polymorphisms (SNPs), some of which promote the development of obesity/type 2 diabetes mel...

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Veröffentlicht in:	Biochemical and biophysical research communications 2002-07, Vol.295 (2), p.207-222
Hauptverfasser:	Kagawa, Yasuo, Yanagisawa, Yoshiko, Hasegawa, Kyoko, Suzuki, Hisano, Yasuda, Kazuto, Kudo, Hideki, Abe, Mieko, Matsuda, Sanae, Ishikawa, Yuko, Tsuchiya, Noriko, Sato, Aya, Umetsu, Kazuo, Kagawa, Yoshiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Diabetes Energy metabolism Evolution, Molecular Genome, Human Genotype Humans mtDNA Obesity - genetics Obesity - prevention & control Phenotype Polymorphism, Single Nucleotide SNP Starvation
Online-Zugang:	Volltext
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