Reduction in the Circulating pDC1/pDC2 Ratio and Impaired Function of Ex Vivo-Generated DC1 In Chronic Hepatitis B Infection

Dendritic cells (DCs) induce and regulate T-cell-mediated immune responses. Circulating precursor (p)DC1 and pDC2 from patients with chronic hepatitis B virus (HBV) infection were quantified by flow cytometry. To assess their function, DC1 were cultured from patients and compared to those of healthy...

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Veröffentlicht in:	Clinical immunology (Orlando, Fla.) Fla.), 2002-08, Vol.104 (2), p.138-150
Hauptverfasser:	Beckebaum, Susanne, Cicinnati, Vito R., Dworacki, Grzegorz, Müller-Berghaus, Jan, Stolz, Donna, Harnaha, Jo, Whiteside, Theresa L., Thomson, Angus W., Lu, Lina, Fung, John J., Bonham, C.Andrew
Format:	Artikel
Sprache:	eng
Schlagworte:	allostimulation antigen presentation Biological and medical sciences Cell Division Cells, Cultured Dendritic Cells - drug effects Dendritic Cells - immunology Dendritic Cells - virology DNA, Viral - analysis DNA, Viral - blood Female Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology Hepatitis B virus - genetics Hepatitis B virus - isolation & purification Hepatitis B, Chronic - blood Hepatitis B, Chronic - immunology Human viral diseases Humans IFN-γ IL-12 Immunophenotyping Infectious diseases Interleukin-12 - analysis Interleukin-4 - pharmacology liver Male Medical sciences Middle Aged Time Factors Viral diseases Viral hepatitis viral infection
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