Developmental Signaling in Hydra: What Does It Take to Build a “Simple” Animal?
Developmental processes in multicellular animals depend on an array of signal transduction pathways. Studies of model organisms have identified a number of such pathways and dissected them in detail. However, these model organisms are all bilaterians. Investigations of the roles of signal transducti...
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| Veröffentlicht in: | Developmental Biology 2002-08, Vol.248 (2), p.199-219 |
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| creator | Steele, Robert E. |
| description | Developmental processes in multicellular animals depend on an array of signal transduction pathways. Studies of model organisms have identified a number of such pathways and dissected them in detail. However, these model organisms are all bilaterians. Investigations of the roles of signal transduction pathways in the early-diverging metazoan
Hydra have revealed that a number of the well-known developmental signaling pathways were already in place in the last common ancestor of
Hydra and bilaterians. In addition to these shared pathways, it appears that developmental processes in
Hydra make use of pathways involving a variety of peptides. Such pathways have not yet been identified as developmental regulators in more recently diverged animals. In this review I will summarize work to date on developmental signaling pathways in
Hydra and discuss the future directions in which such work will need to proceed to realize the potential that lies in this simple animal. |
| doi_str_mv | 10.1006/dbio.2002.0744 |
| format | Article |
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Hydra have revealed that a number of the well-known developmental signaling pathways were already in place in the last common ancestor of
Hydra and bilaterians. In addition to these shared pathways, it appears that developmental processes in
Hydra make use of pathways involving a variety of peptides. Such pathways have not yet been identified as developmental regulators in more recently diverged animals. In this review I will summarize work to date on developmental signaling pathways in
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Hydra have revealed that a number of the well-known developmental signaling pathways were already in place in the last common ancestor of
Hydra and bilaterians. In addition to these shared pathways, it appears that developmental processes in
Hydra make use of pathways involving a variety of peptides. Such pathways have not yet been identified as developmental regulators in more recently diverged animals. In this review I will summarize work to date on developmental signaling pathways in
Hydra and discuss the future directions in which such work will need to proceed to realize the potential that lies in this simple animal.</description><subject>Animals</subject><subject>Biological Evolution</subject><subject>Endothelins - metabolism</subject><subject>Hydra</subject><subject>Hydra - enzymology</subject><subject>Hydra - genetics</subject><subject>Hydra - growth & development</subject><subject>Hydra - metabolism</subject><subject>Membrane Proteins - metabolism</subject><subject>Oligopeptides - genetics</subject><subject>Oligopeptides - metabolism</subject><subject>Peptides - metabolism</subject><subject>Protein-Tyrosine Kinases - metabolism</subject><subject>Proto-Oncogene Proteins - metabolism</subject><subject>ras Proteins - genetics</subject><subject>ras Proteins - metabolism</subject><subject>Receptors, Notch</subject><subject>Signal Transduction</subject><subject>Transforming Growth Factor beta - metabolism</subject><subject>Wnt Proteins</subject><subject>Zebrafish Proteins</subject><issn>0012-1606</issn><issn>1095-564X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkLFOHDEQhq0oUbiQtJSRq3R7mfF6vXaaiEASkJBSHFHSWT7vGBy8u8d6D4mOB4GX40mypzuJClFN880n_R9jBwhzBFCfm2Xs5wJAzKGW8hWbIZiqqJT8-5rNAFAUqEDtsXc5_wOAUuvyLdtDgaoujZmxxTHdUOpXLXWjS3wRLzqXYnfBY8dPbpvBfeF_Lt3Ij3vK_HTk5-6K-Njzb-uYGu744939IrarRI93D_ywi61LX9-zN8GlTB92d5_9_vH9_OikOPv18_To8KzwEnEsnCIjSKKppAasq6Cp0cqTqLEKZagkBCmCcEqRCCSdL700y-A04bLSpMt99mnrXQ399ZryaNuYPaXkOurX2dZoalNqeBFErQxUaCZwvgX90Oc8ULCrYZo03FoEu-ltN73tprfd9J4ePu7M62VLzRO-CzwBegvQFOIm0mCzj9R5auJAfrRNH59z_wfNPI85</recordid><startdate>20020815</startdate><enddate>20020815</enddate><creator>Steele, Robert E.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope><scope>7X8</scope></search><sort><creationdate>20020815</creationdate><title>Developmental Signaling in Hydra: What Does It Take to Build a “Simple” Animal?</title><author>Steele, Robert E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-a6e92e4195480175f8ed86ce2715f3f540f42f2a66e2fe4ac3c49bfa8e1b58e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Biological Evolution</topic><topic>Endothelins - metabolism</topic><topic>Hydra</topic><topic>Hydra - enzymology</topic><topic>Hydra - genetics</topic><topic>Hydra - growth & development</topic><topic>Hydra - metabolism</topic><topic>Membrane Proteins - metabolism</topic><topic>Oligopeptides - genetics</topic><topic>Oligopeptides - metabolism</topic><topic>Peptides - metabolism</topic><topic>Protein-Tyrosine Kinases - metabolism</topic><topic>Proto-Oncogene Proteins - metabolism</topic><topic>ras Proteins - genetics</topic><topic>ras Proteins - metabolism</topic><topic>Receptors, Notch</topic><topic>Signal Transduction</topic><topic>Transforming Growth Factor beta - metabolism</topic><topic>Wnt Proteins</topic><topic>Zebrafish Proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Steele, Robert E.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>MEDLINE - Academic</collection><jtitle>Developmental Biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Steele, Robert E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Developmental Signaling in Hydra: What Does It Take to Build a “Simple” Animal?</atitle><jtitle>Developmental Biology</jtitle><addtitle>Dev Biol</addtitle><date>2002-08-15</date><risdate>2002</risdate><volume>248</volume><issue>2</issue><spage>199</spage><epage>219</epage><pages>199-219</pages><issn>0012-1606</issn><eissn>1095-564X</eissn><abstract>Developmental processes in multicellular animals depend on an array of signal transduction pathways. 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Hydra have revealed that a number of the well-known developmental signaling pathways were already in place in the last common ancestor of
Hydra and bilaterians. In addition to these shared pathways, it appears that developmental processes in
Hydra make use of pathways involving a variety of peptides. Such pathways have not yet been identified as developmental regulators in more recently diverged animals. In this review I will summarize work to date on developmental signaling pathways in
Hydra and discuss the future directions in which such work will need to proceed to realize the potential that lies in this simple animal.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>12167399</pmid><doi>10.1006/dbio.2002.0744</doi><tpages>21</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Developmental Biology, 2002-08, Vol.248 (2), p.199-219 |
| issn | 0012-1606 1095-564X |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present); EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Biological Evolution Endothelins - metabolism Hydra Hydra - enzymology Hydra - genetics Hydra - growth & development Hydra - metabolism Membrane Proteins - metabolism Oligopeptides - genetics Oligopeptides - metabolism Peptides - metabolism Protein-Tyrosine Kinases - metabolism Proto-Oncogene Proteins - metabolism ras Proteins - genetics ras Proteins - metabolism Receptors, Notch Signal Transduction Transforming Growth Factor beta - metabolism Wnt Proteins Zebrafish Proteins |
| title | Developmental Signaling in Hydra: What Does It Take to Build a “Simple” Animal? |
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