Failure of Ibuprofen to prevent progressive dermal ischemia after burning in guinea pigs
Objective: It is controversial whether the use of prostaglandin inhibitors could prevent progressive dermal ischemia in the postburn stasis zone. This study evaluated the effect of Ibuprofen on preventing postburn dermal ischemia using an animal model of India ink perfusion and skin transparent prep...
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| Veröffentlicht in: | Burns 2002-08, Vol.28 (5), p.443-448 |
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| creator | Tan, Qian Lin, Zihao Ma, Wenxi Chen, Huairen Wang, Lei Ning, Guansen Zhou, Xu |
| description | Objective: It is controversial whether the use of prostaglandin inhibitors could prevent progressive dermal ischemia in the postburn stasis zone. This study evaluated the effect of Ibuprofen on preventing postburn dermal ischemia using an animal model of India ink perfusion and skin transparent preparation techniques.
Methods: The closely clipped backs of the guinea pigs were bathed in 75
°C water for 10
s. Ibuprofen-treated groups were fed intragastrically with Ibuprofen (12.5
mg/kg) every 6
h. All animals were perfused with 70% India ink via a cervical artery cannula at 16
kPa constant pressure at 0, 8, 16, 24
h postburn. Skin transparent preparations were made, and 6-keto-PGF
1α and TxB
2 levels in skin tissue were assessed.
Results: India ink filling rates in skin capillary plexuses decreased gradually with postburn time elapsing (
P |
| doi_str_mv | 10.1016/S0305-4179(02)00043-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71979103</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0305417902000438</els_id><sourcerecordid>71979103</sourcerecordid><originalsourceid>FETCH-LOGICAL-c391t-f26771fe0f3718bc8c14900099cb034be0a5b28a1c19a377a45eda8497e477f33</originalsourceid><addsrcrecordid>eNqFkEFv1DAQhS1ERZfCTwD5AoJDykzsxPYJoYrSSpU4FCRuluOMF6PEWexkJf492e6KHjm9y_dmnj7GXiFcImD74R4ENJVEZd5B_R4ApKj0E7ZBrUyFEsxTtvmHnLPnpfxaIWg0PGPnWGMrai027Me1i8OSiU-B33bLLk-BEp8nvsu0pzSvOW0zlRL3xHvKoxt4LP4njdFxF2bKvFtyimnLY-LbJSZyfBe35QU7C24o9PKUF-z79edvVzfV3dcvt1ef7iovDM5VqFulMBAEoVB3XnuUZt1pjO9AyI7ANV2tHXo0TijlZEO909IokkoFIS7Y2-Pddejvhcpsx3UfDYNLNC3FKjTKIBzA5gj6PJWSKdhdjqPLfyyCPSi1D0rtwZeF2j4otXrtvT49WLqR-sfWyeEKvDkBrng3hOySj-WRE7ptlTxwH48crTr2kbItPlLy1MdMfrb9FP8z5S9wJ5LE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71979103</pqid></control><display><type>article</type><title>Failure of Ibuprofen to prevent progressive dermal ischemia after burning in guinea pigs</title><source>Elsevier ScienceDirect Journals Complete - AutoHoldings</source><source>MEDLINE</source><creator>Tan, Qian ; Lin, Zihao ; Ma, Wenxi ; Chen, Huairen ; Wang, Lei ; Ning, Guansen ; Zhou, Xu</creator><creatorcontrib>Tan, Qian ; Lin, Zihao ; Ma, Wenxi ; Chen, Huairen ; Wang, Lei ; Ning, Guansen ; Zhou, Xu</creatorcontrib><description>Objective: It is controversial whether the use of prostaglandin inhibitors could prevent progressive dermal ischemia in the postburn stasis zone. This study evaluated the effect of Ibuprofen on preventing postburn dermal ischemia using an animal model of India ink perfusion and skin transparent preparation techniques.
Methods: The closely clipped backs of the guinea pigs were bathed in 75
°C water for 10
s. Ibuprofen-treated groups were fed intragastrically with Ibuprofen (12.5
mg/kg) every 6
h. All animals were perfused with 70% India ink via a cervical artery cannula at 16
kPa constant pressure at 0, 8, 16, 24
h postburn. Skin transparent preparations were made, and 6-keto-PGF
1α and TxB
2 levels in skin tissue were assessed.
Results: India ink filling rates in skin capillary plexuses decreased gradually with postburn time elapsing (
P<0.01). 6-keto-PGF
1α and TxB
2 levels in two groups increased. The increase of TxB
2 was dominant, which was related to postburn dermal ischemia (
r=0.742,
P<0.01). Though levels of 6-keto-PGF
1α and TxB
2 decreased in Ibuprofen-treated groups, India ink filling rates showed no significant difference between controls and experimental groups (
P>0.05). The results were also confirmed by observation of skin transparent preparations.
Conclusion: This study suggests that Ibuprofen has no preventive effect on progressive dermal ischemia after burning.</description><identifier>ISSN: 0305-4179</identifier><identifier>EISSN: 1879-1409</identifier><identifier>DOI: 10.1016/S0305-4179(02)00043-8</identifier><identifier>PMID: 12163283</identifier><identifier>CODEN: BURND8</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Animals ; Biological and medical sciences ; Burns ; Burns - complications ; Burns - pathology ; Cyclooxygenase Inhibitors - therapeutic use ; Dermal ischemia ; Dermis - blood supply ; Dermis - drug effects ; Dermis - pathology ; Disease Models, Animal ; Emergency and intensive care: burns ; Guinea Pigs ; Ibuprofen ; Ibuprofen - therapeutic use ; Intensive care medicine ; Ischemia - etiology ; Ischemia - pathology ; Ischemia - prevention & control ; Medical sciences ; Microcirculation ; Microcirculation - drug effects ; Time Factors ; Trauma Severity Indices ; Treatment Failure</subject><ispartof>Burns, 2002-08, Vol.28 (5), p.443-448</ispartof><rights>2002 Elsevier Science Ltd and ISBI</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-f26771fe0f3718bc8c14900099cb034be0a5b28a1c19a377a45eda8497e477f33</citedby><cites>FETCH-LOGICAL-c391t-f26771fe0f3718bc8c14900099cb034be0a5b28a1c19a377a45eda8497e477f33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0305-4179(02)00043-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13866743$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12163283$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tan, Qian</creatorcontrib><creatorcontrib>Lin, Zihao</creatorcontrib><creatorcontrib>Ma, Wenxi</creatorcontrib><creatorcontrib>Chen, Huairen</creatorcontrib><creatorcontrib>Wang, Lei</creatorcontrib><creatorcontrib>Ning, Guansen</creatorcontrib><creatorcontrib>Zhou, Xu</creatorcontrib><title>Failure of Ibuprofen to prevent progressive dermal ischemia after burning in guinea pigs</title><title>Burns</title><addtitle>Burns</addtitle><description>Objective: It is controversial whether the use of prostaglandin inhibitors could prevent progressive dermal ischemia in the postburn stasis zone. This study evaluated the effect of Ibuprofen on preventing postburn dermal ischemia using an animal model of India ink perfusion and skin transparent preparation techniques.
Methods: The closely clipped backs of the guinea pigs were bathed in 75
°C water for 10
s. Ibuprofen-treated groups were fed intragastrically with Ibuprofen (12.5
mg/kg) every 6
h. All animals were perfused with 70% India ink via a cervical artery cannula at 16
kPa constant pressure at 0, 8, 16, 24
h postburn. Skin transparent preparations were made, and 6-keto-PGF
1α and TxB
2 levels in skin tissue were assessed.
Results: India ink filling rates in skin capillary plexuses decreased gradually with postburn time elapsing (
P<0.01). 6-keto-PGF
1α and TxB
2 levels in two groups increased. The increase of TxB
2 was dominant, which was related to postburn dermal ischemia (
r=0.742,
P<0.01). Though levels of 6-keto-PGF
1α and TxB
2 decreased in Ibuprofen-treated groups, India ink filling rates showed no significant difference between controls and experimental groups (
P>0.05). The results were also confirmed by observation of skin transparent preparations.
Conclusion: This study suggests that Ibuprofen has no preventive effect on progressive dermal ischemia after burning.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Burns</subject><subject>Burns - complications</subject><subject>Burns - pathology</subject><subject>Cyclooxygenase Inhibitors - therapeutic use</subject><subject>Dermal ischemia</subject><subject>Dermis - blood supply</subject><subject>Dermis - drug effects</subject><subject>Dermis - pathology</subject><subject>Disease Models, Animal</subject><subject>Emergency and intensive care: burns</subject><subject>Guinea Pigs</subject><subject>Ibuprofen</subject><subject>Ibuprofen - therapeutic use</subject><subject>Intensive care medicine</subject><subject>Ischemia - etiology</subject><subject>Ischemia - pathology</subject><subject>Ischemia - prevention & control</subject><subject>Medical sciences</subject><subject>Microcirculation</subject><subject>Microcirculation - drug effects</subject><subject>Time Factors</subject><subject>Trauma Severity Indices</subject><subject>Treatment Failure</subject><issn>0305-4179</issn><issn>1879-1409</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEFv1DAQhS1ERZfCTwD5AoJDykzsxPYJoYrSSpU4FCRuluOMF6PEWexkJf492e6KHjm9y_dmnj7GXiFcImD74R4ENJVEZd5B_R4ApKj0E7ZBrUyFEsxTtvmHnLPnpfxaIWg0PGPnWGMrai027Me1i8OSiU-B33bLLk-BEp8nvsu0pzSvOW0zlRL3xHvKoxt4LP4njdFxF2bKvFtyimnLY-LbJSZyfBe35QU7C24o9PKUF-z79edvVzfV3dcvt1ef7iovDM5VqFulMBAEoVB3XnuUZt1pjO9AyI7ANV2tHXo0TijlZEO909IokkoFIS7Y2-Pddejvhcpsx3UfDYNLNC3FKjTKIBzA5gj6PJWSKdhdjqPLfyyCPSi1D0rtwZeF2j4otXrtvT49WLqR-sfWyeEKvDkBrng3hOySj-WRE7ptlTxwH48crTr2kbItPlLy1MdMfrb9FP8z5S9wJ5LE</recordid><startdate>20020801</startdate><enddate>20020801</enddate><creator>Tan, Qian</creator><creator>Lin, Zihao</creator><creator>Ma, Wenxi</creator><creator>Chen, Huairen</creator><creator>Wang, Lei</creator><creator>Ning, Guansen</creator><creator>Zhou, Xu</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020801</creationdate><title>Failure of Ibuprofen to prevent progressive dermal ischemia after burning in guinea pigs</title><author>Tan, Qian ; Lin, Zihao ; Ma, Wenxi ; Chen, Huairen ; Wang, Lei ; Ning, Guansen ; Zhou, Xu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-f26771fe0f3718bc8c14900099cb034be0a5b28a1c19a377a45eda8497e477f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Burns</topic><topic>Burns - complications</topic><topic>Burns - pathology</topic><topic>Cyclooxygenase Inhibitors - therapeutic use</topic><topic>Dermal ischemia</topic><topic>Dermis - blood supply</topic><topic>Dermis - drug effects</topic><topic>Dermis - pathology</topic><topic>Disease Models, Animal</topic><topic>Emergency and intensive care: burns</topic><topic>Guinea Pigs</topic><topic>Ibuprofen</topic><topic>Ibuprofen - therapeutic use</topic><topic>Intensive care medicine</topic><topic>Ischemia - etiology</topic><topic>Ischemia - pathology</topic><topic>Ischemia - prevention & control</topic><topic>Medical sciences</topic><topic>Microcirculation</topic><topic>Microcirculation - drug effects</topic><topic>Time Factors</topic><topic>Trauma Severity Indices</topic><topic>Treatment Failure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tan, Qian</creatorcontrib><creatorcontrib>Lin, Zihao</creatorcontrib><creatorcontrib>Ma, Wenxi</creatorcontrib><creatorcontrib>Chen, Huairen</creatorcontrib><creatorcontrib>Wang, Lei</creatorcontrib><creatorcontrib>Ning, Guansen</creatorcontrib><creatorcontrib>Zhou, Xu</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Burns</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tan, Qian</au><au>Lin, Zihao</au><au>Ma, Wenxi</au><au>Chen, Huairen</au><au>Wang, Lei</au><au>Ning, Guansen</au><au>Zhou, Xu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Failure of Ibuprofen to prevent progressive dermal ischemia after burning in guinea pigs</atitle><jtitle>Burns</jtitle><addtitle>Burns</addtitle><date>2002-08-01</date><risdate>2002</risdate><volume>28</volume><issue>5</issue><spage>443</spage><epage>448</epage><pages>443-448</pages><issn>0305-4179</issn><eissn>1879-1409</eissn><coden>BURND8</coden><abstract>Objective: It is controversial whether the use of prostaglandin inhibitors could prevent progressive dermal ischemia in the postburn stasis zone. This study evaluated the effect of Ibuprofen on preventing postburn dermal ischemia using an animal model of India ink perfusion and skin transparent preparation techniques.
Methods: The closely clipped backs of the guinea pigs were bathed in 75
°C water for 10
s. Ibuprofen-treated groups were fed intragastrically with Ibuprofen (12.5
mg/kg) every 6
h. All animals were perfused with 70% India ink via a cervical artery cannula at 16
kPa constant pressure at 0, 8, 16, 24
h postburn. Skin transparent preparations were made, and 6-keto-PGF
1α and TxB
2 levels in skin tissue were assessed.
Results: India ink filling rates in skin capillary plexuses decreased gradually with postburn time elapsing (
P<0.01). 6-keto-PGF
1α and TxB
2 levels in two groups increased. The increase of TxB
2 was dominant, which was related to postburn dermal ischemia (
r=0.742,
P<0.01). Though levels of 6-keto-PGF
1α and TxB
2 decreased in Ibuprofen-treated groups, India ink filling rates showed no significant difference between controls and experimental groups (
P>0.05). The results were also confirmed by observation of skin transparent preparations.
Conclusion: This study suggests that Ibuprofen has no preventive effect on progressive dermal ischemia after burning.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>12163283</pmid><doi>10.1016/S0305-4179(02)00043-8</doi><tpages>6</tpages></addata></record> |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Burns Burns - complications Burns - pathology Cyclooxygenase Inhibitors - therapeutic use Dermal ischemia Dermis - blood supply Dermis - drug effects Dermis - pathology Disease Models, Animal Emergency and intensive care: burns Guinea Pigs Ibuprofen Ibuprofen - therapeutic use Intensive care medicine Ischemia - etiology Ischemia - pathology Ischemia - prevention & control Medical sciences Microcirculation Microcirculation - drug effects Time Factors Trauma Severity Indices Treatment Failure |
| title | Failure of Ibuprofen to prevent progressive dermal ischemia after burning in guinea pigs |
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