Neuroendocrine and biologic features of primary tumors and tissue in pulmonary large cell carcinomas

Because biological behavior in lung tumors with neuroendocrine differentiation is highly dependent on cell death (apoptosis) and angiogenesis, p21 waf1/cip1 and microvessel density have been targeted as potentially useful tumor markers. We sought to validate the importance of p21 waf1/cip1 and micro...

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Veröffentlicht in:	The Annals of thoracic surgery 2004-06, Vol.77 (6), p.1883-1890
Hauptverfasser:	Ab' Saber, Alexandre M, Massoni Neto, Ledo Mazzei, Bianchi, Cristina P, Ctenas, Bruno B, Parra, Edwin R, Eher, Esmeralda M, Pereira, João Carlos, Takagaki, Teresa, Yamaguchi, Nise H, Capelozzi, Vera L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Carcinoma, Large Cell - chemistry Carcinoma, Large Cell - mortality Carcinoma, Large Cell - pathology Carcinoma, Neuroendocrine - chemistry Carcinoma, Neuroendocrine - mortality Carcinoma, Neuroendocrine - pathology Cardiology. Vascular system Cyclin-Dependent Kinase Inhibitor p21 Cyclins - analysis Cyclooxygenase 2 Female Humans Immunohistochemistry Isoenzymes - analysis Lung Neoplasms - chemistry Lung Neoplasms - mortality Lung Neoplasms - pathology Male Matrix Metalloproteinase 9 - analysis Medical sciences Membrane Proteins Middle Aged Pneumology Proportional Hazards Models Prostaglandin-Endoperoxide Synthases - analysis Retrospective Studies Survival Rate Tumor Suppressor Protein p53 - analysis
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