Infiltrating leukocytes confound the detection of E-cadherin promoter methylation in tumors

Promoter hypermethylation is known to result in transcriptional downregulation of many genes including the CDH1 gene. In this study we set out to determine CDH1 promoter methylation in breast tumors with decreased or absent E-cadherin protein expression and without CDH1 gene mutations by methylation...

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Veröffentlicht in:	Biochemical and biophysical research communications 2004-06, Vol.319 (2), p.697-704
Hauptverfasser:	Lombaerts, Marcel, Middeldorp, Janneke W., van der Weide, Esther, Philippo, Katja, van Wezel, Tom, Smit, Vincent T.H.B.M., Cornelisse, Cees J., Cleton-Jansen, Anne-Marie
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cadherins - genetics DNA Methylation E-cadherin Humans Infiltrating leukocytes Leukocytes - cytology Methylation-specific PCR Polymerase Chain Reaction Promoter methylation Promoter Regions, Genetic
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