Distinct haplotype profiles and strong linkage disequilibrium at the MDR1 multidrug transporter gene locus in three ethnic Asian populations

The MDR1 multidrug transporter plays a key role in determining drug bioavailability, and differences in drug response exist amongst different ethnic groups. Numerous studies have identified an association between the MDR1 single nucleotide polymorphism (SNP) exon 26 3435C>T and differences in MDR...

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Veröffentlicht in:	Pharmacogenetics (London) 2002-08, Vol.12 (6), p.437-450
Hauptverfasser:	KUN TANG, NGOI, Soo-Mun, GWEE, Pai-Chung, CHUA, John M. Z, LEE, Edmund J. D, CHONG, Samuel S, LEE, Caroline G. L
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Untranslated Regions - genetics Alleles Biological and medical sciences Cell membranes. Ionic channels. Membrane pores Cell structures and functions China - ethnology DNA - blood DNA - genetics DNA - metabolism DNA Primers - chemistry Ethnic Groups - genetics Exons - genetics Fundamental and applied biological sciences. Psychology Gene Frequency Genes, MDR - genetics Genes. Genome Genetic Markers Genetics of eukaryotes. Biological and molecular evolution Genotype Haplotypes Human Humans India - ethnology Introns - genetics Linkage Disequilibrium Malaysia - ethnology Molecular and cellular biology Molecular genetics Polymerase Chain Reaction Polymorphism, Restriction Fragment Length Polymorphism, Single Nucleotide - genetics Population genetics, reproduction patterns Promoter Regions, Genetic Singapore - ethnology
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