Differential expression of type IV collagen isoforms in rat glomerular endothelial and mesangial cells

Type IV collagen, which is encoded by six genetically distinct α-chains (α1–α6), is a major component of the kidney glomerulus. The α1(IV) and α2(IV) chains are present predominantly in the mesangial matrix, whereas the α3(IV), α4(IV), and α5(IV) chains are localized almost exclusively to the glomer...

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Veröffentlicht in:	Biochemical and biophysical research communications 2002-07, Vol.295 (2), p.401-407
Hauptverfasser:	Zeisberg, Michael, Ericksen, Mark B, Hamano, Yuki, Neilson, Eric G, Ziyadeh, Fuad, Kalluri, Raghu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Collagen isoforms Collagen Type IV - metabolism Diabetic Nephropathies - metabolism Diabetic nephropathy Endothelium - cytology Endothelium - metabolism Glomerular basement membrane Glomerular Mesangium - cytology Glomerular Mesangium - metabolism Glucose - pharmacology Kidney Glomerulus - cytology Kidney Glomerulus - metabolism Protein Isoforms - metabolism Rats Transforming Growth Factor beta - biosynthesis Type IV collagen
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