Reversal of benzodiazepine-induced renal vasculature relaxation with flumazenil
The effects of the central-type benzodiazepine receptor antagonist flumazenil on renal vascular tone and its ability to reverse the benzodiazepine-induced vasodilation were investigated. The isolated and perfused rat kidney model was used. Flumazenil was unable to modify renal vascular resistance un...
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| Veröffentlicht in: | European journal of pharmacology 2002-08, Vol.449 (1-2), p.155-158 |
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| container_title | European journal of pharmacology |
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| creator | Monasterolo, Liliana A Trumper, Laura Elı́as, M.Mónica |
| description | The effects of the central-type benzodiazepine receptor antagonist flumazenil on renal vascular tone and its ability to reverse the benzodiazepine-induced vasodilation were investigated. The isolated and perfused rat kidney model was used. Flumazenil was unable to modify renal vascular resistance under basal conditions and in noradrenaline-pretreated kidneys. Relaxation induced by diazepam or clonazepam of noradrenaline-preconstricted renal vasculature was blunted by 10 μM flumazenil. These results suggest that central-type benzodiazepine receptors could be involved in benzodiazepine-induced renal vasodilation. |
| doi_str_mv | 10.1016/S0014-2999(02)01942-8 |
| format | Article |
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The isolated and perfused rat kidney model was used. Flumazenil was unable to modify renal vascular resistance under basal conditions and in noradrenaline-pretreated kidneys. Relaxation induced by diazepam or clonazepam of noradrenaline-preconstricted renal vasculature was blunted by 10 μM flumazenil. These results suggest that central-type benzodiazepine receptors could be involved in benzodiazepine-induced renal vasodilation.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/S0014-2999(02)01942-8</identifier><identifier>PMID: 12163119</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Benzodiazepine ; Biological and medical sciences ; Cardiovascular system ; Clonazepam - pharmacology ; Diazepam - antagonists & inhibitors ; Diazepam - pharmacology ; Flumazenil - pharmacology ; GABA Modulators - pharmacology ; Kidney ; Male ; Medical sciences ; Muscle Relaxants, Central - antagonists & inhibitors ; Muscle Relaxants, Central - pharmacology ; Muscle Relaxation - drug effects ; Muscle, Smooth, Vascular - drug effects ; Norepinephrine - pharmacology ; Pharmacology. Drug treatments ; Rat ; Rats ; Rats, Wistar ; Renal Circulation - drug effects ; Vasculature ; Vasoconstrictor Agents - pharmacology ; Vasodilator agents. 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The isolated and perfused rat kidney model was used. Flumazenil was unable to modify renal vascular resistance under basal conditions and in noradrenaline-pretreated kidneys. Relaxation induced by diazepam or clonazepam of noradrenaline-preconstricted renal vasculature was blunted by 10 μM flumazenil. These results suggest that central-type benzodiazepine receptors could be involved in benzodiazepine-induced renal vasodilation.</description><subject>Animals</subject><subject>Benzodiazepine</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular system</subject><subject>Clonazepam - pharmacology</subject><subject>Diazepam - antagonists & inhibitors</subject><subject>Diazepam - pharmacology</subject><subject>Flumazenil - pharmacology</subject><subject>GABA Modulators - pharmacology</subject><subject>Kidney</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Muscle Relaxants, Central - antagonists & inhibitors</subject><subject>Muscle Relaxants, Central - pharmacology</subject><subject>Muscle Relaxation - drug effects</subject><subject>Muscle, Smooth, Vascular - drug effects</subject><subject>Norepinephrine - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Renal Circulation - drug effects</subject><subject>Vasculature</subject><subject>Vasoconstrictor Agents - pharmacology</subject><subject>Vasodilator agents. Cerebral vasodilators</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0E1PHCEYwHHS1HTX1Y_QZi419jAWGGYYTsZsbDUxMbF6Jrw8pDQss4WZrfrpZd1NPXoigd8D5I_QZ4LPCCbd918YE1ZTIcQppt8wEYzW_Qc0Jz0XNeaEfkTz_2SGDnP-gzFuBW0_oRmhpGsIEXN0ewcbSFmFanCVhvg8WK-eYe0j1D7ayYCtEsRyvlHZTEGNU4KyE9SjGv0Qq39-_F25MK3KVPThCB04FTIc79cFevhxeb-8qm9uf14vL25q0wgy1rq1He-a1jAtmLKMdhyE08AVMMd61YE2bdM6XYjrrbWaad47bLkiSneuWaCT3b3rNPydII9y5bOBEFSEYcqSE8E5ZbjAdgdNGnJO4OQ6-ZVKT5JguS0pX0vKbSaJqXwtKfsy92X_wKRXYN-m9ukK-LoHJYwKLqlofH5zTc-KI8Wd7xyUHBsPSWbjIZawPoEZpR38O195AdeJkmQ</recordid><startdate>20020802</startdate><enddate>20020802</enddate><creator>Monasterolo, Liliana A</creator><creator>Trumper, Laura</creator><creator>Elı́as, M.Mónica</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020802</creationdate><title>Reversal of benzodiazepine-induced renal vasculature relaxation with flumazenil</title><author>Monasterolo, Liliana A ; Trumper, Laura ; Elı́as, M.Mónica</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-b5d67635c4b94ad4267e9fbe7ae4f48a6ebc535fb35cf8dddb4b78f0d7a1ab6f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Benzodiazepine</topic><topic>Biological and medical sciences</topic><topic>Cardiovascular system</topic><topic>Clonazepam - pharmacology</topic><topic>Diazepam - antagonists & inhibitors</topic><topic>Diazepam - pharmacology</topic><topic>Flumazenil - pharmacology</topic><topic>GABA Modulators - pharmacology</topic><topic>Kidney</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Muscle Relaxants, Central - antagonists & inhibitors</topic><topic>Muscle Relaxants, Central - pharmacology</topic><topic>Muscle Relaxation - drug effects</topic><topic>Muscle, Smooth, Vascular - drug effects</topic><topic>Norepinephrine - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Renal Circulation - drug effects</topic><topic>Vasculature</topic><topic>Vasoconstrictor Agents - pharmacology</topic><topic>Vasodilator agents. Cerebral vasodilators</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Monasterolo, Liliana A</creatorcontrib><creatorcontrib>Trumper, Laura</creatorcontrib><creatorcontrib>Elı́as, M.Mónica</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Monasterolo, Liliana A</au><au>Trumper, Laura</au><au>Elı́as, M.Mónica</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reversal of benzodiazepine-induced renal vasculature relaxation with flumazenil</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>2002-08-02</date><risdate>2002</risdate><volume>449</volume><issue>1-2</issue><spage>155</spage><epage>158</epage><pages>155-158</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>The effects of the central-type benzodiazepine receptor antagonist flumazenil on renal vascular tone and its ability to reverse the benzodiazepine-induced vasodilation were investigated. The isolated and perfused rat kidney model was used. Flumazenil was unable to modify renal vascular resistance under basal conditions and in noradrenaline-pretreated kidneys. Relaxation induced by diazepam or clonazepam of noradrenaline-preconstricted renal vasculature was blunted by 10 μM flumazenil. These results suggest that central-type benzodiazepine receptors could be involved in benzodiazepine-induced renal vasodilation.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>12163119</pmid><doi>10.1016/S0014-2999(02)01942-8</doi><tpages>4</tpages></addata></record> |
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| ispartof | European journal of pharmacology, 2002-08, Vol.449 (1-2), p.155-158 |
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| subjects | Animals Benzodiazepine Biological and medical sciences Cardiovascular system Clonazepam - pharmacology Diazepam - antagonists & inhibitors Diazepam - pharmacology Flumazenil - pharmacology GABA Modulators - pharmacology Kidney Male Medical sciences Muscle Relaxants, Central - antagonists & inhibitors Muscle Relaxants, Central - pharmacology Muscle Relaxation - drug effects Muscle, Smooth, Vascular - drug effects Norepinephrine - pharmacology Pharmacology. Drug treatments Rat Rats Rats, Wistar Renal Circulation - drug effects Vasculature Vasoconstrictor Agents - pharmacology Vasodilator agents. Cerebral vasodilators |
| title | Reversal of benzodiazepine-induced renal vasculature relaxation with flumazenil |
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