Capsaicin Receptor Expression in Rat Laryngeal Innervation
Capsaicin elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. Vanilloid receptor subtype 1 (VR1) and the vanilloid receptor-like protein 1 (VRL-1) are activated, not only by capsaicin, but also by...
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| Veröffentlicht in: | Annals of otology, rhinology & laryngology rhinology & laryngology, 2004-05, Vol.113 (5), p.356-358 |
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| container_title | Annals of otology, rhinology & laryngology |
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| creator | Uno, Toshiyuki Koike, Shinobu Hirota, Ryuichi Bamba, Hitoshi Hisa, Yasuo |
| description | Capsaicin elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. Vanilloid receptor subtype 1 (VR1) and the vanilloid receptor-like protein 1 (VRL-1) are activated, not only by capsaicin, but also by noxious heat and protons, and it has been suggested that they are polymodal nociceptors. We investigated the expression of VR1 and VRL-1 in the rat larynx and nodose ganglion using VR1 and VRL-1 immunohistochemical analysis with visualization by diaminobenzidine reaction. Fibers positive for VRL-1 were detected in the laryngeal epithelium and lamina propria. Cells positive for VRL-1 were distributed in the intralaryngeal ganglia. Half of the neurons in the nodose ganglion had VR-1 immunoreactivity, and almost 10% of the nodose ganglion neurons were positive for VRL-1. These findings suggest that these capsaicin receptors play an important role in the nociception of the laryngeal innervation. |
| doi_str_mv | 10.1177/000348940411300503 |
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Vanilloid receptor subtype 1 (VR1) and the vanilloid receptor-like protein 1 (VRL-1) are activated, not only by capsaicin, but also by noxious heat and protons, and it has been suggested that they are polymodal nociceptors. We investigated the expression of VR1 and VRL-1 in the rat larynx and nodose ganglion using VR1 and VRL-1 immunohistochemical analysis with visualization by diaminobenzidine reaction. Fibers positive for VRL-1 were detected in the laryngeal epithelium and lamina propria. Cells positive for VRL-1 were distributed in the intralaryngeal ganglia. Half of the neurons in the nodose ganglion had VR-1 immunoreactivity, and almost 10% of the nodose ganglion neurons were positive for VRL-1. These findings suggest that these capsaicin receptors play an important role in the nociception of the laryngeal innervation.</description><identifier>ISSN: 0003-4894</identifier><identifier>EISSN: 1943-572X</identifier><identifier>DOI: 10.1177/000348940411300503</identifier><identifier>PMID: 15174761</identifier><identifier>CODEN: AORHA2</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Animals ; Biological and medical sciences ; Immunohistochemistry ; Laryngeal Mucosa - innervation ; Laryngeal Mucosa - metabolism ; Laryngeal Nerves - drug effects ; Laryngeal Nerves - metabolism ; Medical sciences ; Nerve Fibers - metabolism ; Neurons - metabolism ; Nodose Ganglion - drug effects ; Nodose Ganglion - metabolism ; Otorhinolaryngology. 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These findings suggest that these capsaicin receptors play an important role in the nociception of the laryngeal innervation.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Immunohistochemistry</subject><subject>Laryngeal Mucosa - innervation</subject><subject>Laryngeal Mucosa - metabolism</subject><subject>Laryngeal Nerves - drug effects</subject><subject>Laryngeal Nerves - metabolism</subject><subject>Medical sciences</subject><subject>Nerve Fibers - metabolism</subject><subject>Neurons - metabolism</subject><subject>Nodose Ganglion - drug effects</subject><subject>Nodose Ganglion - metabolism</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Pain - physiopathology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Drug - drug effects</subject><subject>Receptors, Drug - metabolism</subject><subject>TRPV Cation Channels</subject><issn>0003-4894</issn><issn>1943-572X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp90FFLwzAQAOAgipvTP-CDFEHf6i5t2jS-yZg6GAii4FvJkuvo6NKatKL_3pQVJgo-hJDku8vdEXJO4YZSzqcAELNMMGCUxgAJxAdkTAWLw4RHb4dk3IOwFyNy4tzGH1kC0TEZ0YRyxlM6Jrcz2ThZqtIEz6iwaWsbzD8bi86VtQn6a9kGS2m_zBplFSyMQfshW_94So4KWTk8G_YJeb2fv8wew-XTw2J2twwVS6M2TDOdcq45XRVaF1IUWab9ipiOFYIUKya5iCDWkAImKESKQmcpFwIRKUviCbne5W1s_d6ha_Nt6RRWlTRYdy7nVPhWstjDy19wU3fW-NryiHIBkAnhUbRDytbOWSzyxpZb319OIe_Hmv8dqw-6GDJ3qy3qfcgwRw-uBiCdklVhpVGl--E8EpR7N905J9e4L--fr78B5u-LIA</recordid><startdate>20040501</startdate><enddate>20040501</enddate><creator>Uno, Toshiyuki</creator><creator>Koike, Shinobu</creator><creator>Hirota, Ryuichi</creator><creator>Bamba, Hitoshi</creator><creator>Hisa, Yasuo</creator><general>SAGE Publications</general><general>Annals Publishing Compagny</general><general>SAGE PUBLICATIONS, INC</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>20040501</creationdate><title>Capsaicin Receptor Expression in Rat Laryngeal Innervation</title><author>Uno, Toshiyuki ; Koike, Shinobu ; Hirota, Ryuichi ; Bamba, Hitoshi ; Hisa, Yasuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-68d677d71bfddfa9f88df8824d3ce0a9b4a79203d060e5e996e9d86799eee1453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Immunohistochemistry</topic><topic>Laryngeal Mucosa - innervation</topic><topic>Laryngeal Mucosa - metabolism</topic><topic>Laryngeal Nerves - drug effects</topic><topic>Laryngeal Nerves - metabolism</topic><topic>Medical sciences</topic><topic>Nerve Fibers - metabolism</topic><topic>Neurons - metabolism</topic><topic>Nodose Ganglion - drug effects</topic><topic>Nodose Ganglion - metabolism</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Pain - physiopathology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Drug - drug effects</topic><topic>Receptors, Drug - metabolism</topic><topic>TRPV Cation Channels</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Uno, Toshiyuki</creatorcontrib><creatorcontrib>Koike, Shinobu</creatorcontrib><creatorcontrib>Hirota, Ryuichi</creatorcontrib><creatorcontrib>Bamba, Hitoshi</creatorcontrib><creatorcontrib>Hisa, Yasuo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Annals of otology, rhinology & laryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Uno, Toshiyuki</au><au>Koike, Shinobu</au><au>Hirota, Ryuichi</au><au>Bamba, Hitoshi</au><au>Hisa, Yasuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Capsaicin Receptor Expression in Rat Laryngeal Innervation</atitle><jtitle>Annals of otology, rhinology & laryngology</jtitle><addtitle>Ann Otol Rhinol Laryngol</addtitle><date>2004-05-01</date><risdate>2004</risdate><volume>113</volume><issue>5</issue><spage>356</spage><epage>358</epage><pages>356-358</pages><issn>0003-4894</issn><eissn>1943-572X</eissn><coden>AORHA2</coden><abstract>Capsaicin elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. Vanilloid receptor subtype 1 (VR1) and the vanilloid receptor-like protein 1 (VRL-1) are activated, not only by capsaicin, but also by noxious heat and protons, and it has been suggested that they are polymodal nociceptors. We investigated the expression of VR1 and VRL-1 in the rat larynx and nodose ganglion using VR1 and VRL-1 immunohistochemical analysis with visualization by diaminobenzidine reaction. Fibers positive for VRL-1 were detected in the laryngeal epithelium and lamina propria. Cells positive for VRL-1 were distributed in the intralaryngeal ganglia. Half of the neurons in the nodose ganglion had VR-1 immunoreactivity, and almost 10% of the nodose ganglion neurons were positive for VRL-1. These findings suggest that these capsaicin receptors play an important role in the nociception of the laryngeal innervation.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>15174761</pmid><doi>10.1177/000348940411300503</doi><tpages>3</tpages></addata></record> |
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| ispartof | Annals of otology, rhinology & laryngology, 2004-05, Vol.113 (5), p.356-358 |
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| subjects | Animals Biological and medical sciences Immunohistochemistry Laryngeal Mucosa - innervation Laryngeal Mucosa - metabolism Laryngeal Nerves - drug effects Laryngeal Nerves - metabolism Medical sciences Nerve Fibers - metabolism Neurons - metabolism Nodose Ganglion - drug effects Nodose Ganglion - metabolism Otorhinolaryngology. Stomatology Pain - physiopathology Rats Rats, Sprague-Dawley Receptors, Drug - drug effects Receptors, Drug - metabolism TRPV Cation Channels |
| title | Capsaicin Receptor Expression in Rat Laryngeal Innervation |
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