Structural Mimicry of Retroviral Tat Proteins by Constrained β-Hairpin Peptidomimetics: Ligands with High Affinity and Selectivity for Viral TAR RNA Regulatory Elements

An approach is described to the design of β-hairpin peptidomimetic ligands for bovine immunodeficiency virus (BIV) Tat protein, which inhibit binding to its transactivator response element (TAR) RNA. A library of peptidomimetics was derived by grafting onto a hairpin-inducing d-Pro-l-Pro template se...

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Veröffentlicht in:	Journal of the American Chemical Society 2004-06, Vol.126 (22), p.6906-6913
Hauptverfasser:	Athanassiou, Zafiria, Dias, Ricardo L. A, Moehle, Kerstin, Dobson, Neil, Varani, Gabriele, Robinson, John A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Pairing Base Sequence Biological and medical sciences Bovine immunodeficiency virus Cattle Electrophoretic Mobility Shift Assay Fundamental and applied biological sciences. Psychology Gene Products, tat - chemistry Human immunodeficiency virus 1 Immunodeficiency Virus, Bovine - chemistry Immunodeficiency Virus, Bovine - genetics Interactions. Associations Intermolecular phenomena Ligands Magnetic Resonance Spectroscopy Models, Molecular Molecular biophysics Molecular Mimicry Molecular Sequence Data Peptide Fragments - chemistry Peptide Fragments - metabolism Peptides, Cyclic - chemistry Peptides, Cyclic - metabolism Protein Structure, Tertiary RNA, Viral - chemistry RNA, Viral - genetics RNA, Viral - metabolism RNA-Binding Proteins - chemistry RNA-Binding Proteins - metabolism
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