Pharmacokinetics of Tranexamic acid during cardiopulmonary bypass

Tranexamic acid (TA) reduces blood loss and blood transfusion during heart surgery with cardiopulmonary bypass (CPB). TA dosing has been empiric because only limited pharmacokinetic studies have been reported, and CPB effects have not been characterized. We hypothesized that many of the published TA...

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Veröffentlicht in:	Anesthesiology (Philadelphia) 2002-08, Vol.97 (2), p.390-399
Hauptverfasser:	DOWD, Noreen P, KARSKI, Jacek M, CHENG, Davy C, CARROLL, Jo A, YONGGU LIN, JAMES, Robert L, BUTTERWORTH, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Anesthesia Anesthesia depending on type of surgery Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antifibrinolytic Agents - blood Antifibrinolytic Agents - pharmacokinetics Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Cardiopulmonary Bypass Chromatography, High Pressure Liquid Female Humans Male Medical sciences Metabolic Clearance Rate Middle Aged Models, Biological Pharmacology. Drug treatments Thoracic and cardiovascular surgery. Cardiopulmonary bypass Tranexamic Acid - blood Tranexamic Acid - pharmacokinetics
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