Add-on treatment with pyridoxine and sulthiame in 12 infants with West syndrome: an open clinical study
To investigate the effect of sulthiame (STM) in West syndrome (WS) an open, uncontrolled add-on study was undertaken during initial pyridoxine (PDX) therapy in 12 infants, two with idiopathic and ten with symptomatic WS. All patients were initially treated with PDX (150–300 mg kg −1body weight day−1...
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| Veröffentlicht in: | Seizure (London, England) England), 2002-09, Vol.11 (6), p.381-383 |
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| creator | Debus, Otfried Martin Köhring, Jessika Fiedler, Barbara Franssen, Maike Kurlemann, Gerhard |
| description | To investigate the effect of sulthiame (STM) in West syndrome (WS) an open, uncontrolled add-on study was undertaken during initial pyridoxine (PDX) therapy in 12 infants, two with idiopathic and ten with symptomatic WS. All patients were initially treated with PDX (150–300 mg kg −1body weight day−1 ). In seven patients (58%) seizures and hypsarrhythmia stopped during the week after introduction of STM (10 mg kg −1body weight day −1). In one the positive effect was temporary. Five of the responders (42%) remained seizure-free and without hypsarrhythmia under STM monotherapy, while one developed complex partial seizures after 25 months. STM was most effective in idiopathic WS (2 /2). During treatment with STM medication no patient suffered side effects attributable to the substance. Further controlled studies are necessary to evaluate the benefit of this potentially effective treatment. |
| doi_str_mv | 10.1053/seiz.2001.0667 |
| format | Article |
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Further controlled studies are necessary to evaluate the benefit of this potentially effective treatment.</description><subject>add-on therapy</subject><subject>Anticonvulsants - therapeutic use</subject><subject>Carbamazepine - therapeutic use</subject><subject>Drug Therapy, Combination</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>pyridoxine</subject><subject>Pyridoxine - therapeutic use</subject><subject>Spasms, Infantile - drug therapy</subject><subject>sulthiame</subject><subject>Thiazines - therapeutic use</subject><subject>West syndrome</subject><issn>1059-1311</issn><issn>1532-2688</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kD1PwzAQhi0EolBYGZEnthRfnKQJW1XxJVViATFarn2mRolTbAcovx5XrcTEcnfDc6_uHkIugE2Alfw6oP2Z5IzBhFXV9ICcQMnzLK_q-jDNrGwy4AAjchrCO2OsKYAfkxHkUCW-OiFvM62z3tHoUcYOXaRfNq7oeuOt7r-tQyqdpmFo48rKDql1FPJUjXQx7NhXDJGGjdO-7_Am8bRfo6Oqtc4q2dIQB705I0dGtgHP931MXu5un-cP2eLp_nE-W2SK1yxmyjAJqmBGYqO0KXNTpVeQKc04Qp03hivglQEoUEKpWLGsjELksq5rI0s-Jle73LXvP4Z0mehsUNi20mE_BDGFZlo0DU_gZAcq34fg0Yi1t530GwFMbNWKrVqxVSu2atPC5T55WHao__C9ywTUOwDTf58WvQjKolOorUcVhe7tf9m_7n2Jyg</recordid><startdate>20020901</startdate><enddate>20020901</enddate><creator>Debus, Otfried Martin</creator><creator>Köhring, Jessika</creator><creator>Fiedler, Barbara</creator><creator>Franssen, Maike</creator><creator>Kurlemann, Gerhard</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020901</creationdate><title>Add-on treatment with pyridoxine and sulthiame in 12 infants with West syndrome: an open clinical study</title><author>Debus, Otfried Martin ; Köhring, Jessika ; Fiedler, Barbara ; Franssen, Maike ; Kurlemann, Gerhard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c380t-cf0a1c40fae9cdf52f6688e0cd03e1829f3c136f114ea15c04b6fcee3a888fa53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>add-on therapy</topic><topic>Anticonvulsants - therapeutic use</topic><topic>Carbamazepine - therapeutic use</topic><topic>Drug Therapy, Combination</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>pyridoxine</topic><topic>Pyridoxine - therapeutic use</topic><topic>Spasms, Infantile - drug therapy</topic><topic>sulthiame</topic><topic>Thiazines - therapeutic use</topic><topic>West syndrome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Debus, Otfried Martin</creatorcontrib><creatorcontrib>Köhring, Jessika</creatorcontrib><creatorcontrib>Fiedler, Barbara</creatorcontrib><creatorcontrib>Franssen, Maike</creatorcontrib><creatorcontrib>Kurlemann, Gerhard</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Seizure (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Debus, Otfried Martin</au><au>Köhring, Jessika</au><au>Fiedler, Barbara</au><au>Franssen, Maike</au><au>Kurlemann, Gerhard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Add-on treatment with pyridoxine and sulthiame in 12 infants with West syndrome: an open clinical study</atitle><jtitle>Seizure (London, England)</jtitle><addtitle>Seizure</addtitle><date>2002-09-01</date><risdate>2002</risdate><volume>11</volume><issue>6</issue><spage>381</spage><epage>383</epage><pages>381-383</pages><issn>1059-1311</issn><eissn>1532-2688</eissn><abstract>To investigate the effect of sulthiame (STM) in West syndrome (WS) an open, uncontrolled add-on study was undertaken during initial pyridoxine (PDX) therapy in 12 infants, two with idiopathic and ten with symptomatic WS. 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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | add-on therapy Anticonvulsants - therapeutic use Carbamazepine - therapeutic use Drug Therapy, Combination Humans Infant Male pyridoxine Pyridoxine - therapeutic use Spasms, Infantile - drug therapy sulthiame Thiazines - therapeutic use West syndrome |
| title | Add-on treatment with pyridoxine and sulthiame in 12 infants with West syndrome: an open clinical study |
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