The Expression of 11β-Hydroxysteroid Dehydrogenase Type 2 Is Induced during Trophoblast Differentiation: Effects of Hypoxia

The intracellular enzyme 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) catalyzes the unidirectional conversion of bioactive glucocorticoids to their inert metabolites. In the human placenta, 11β-HSD2 is highly expressed in syncytiotrophoblasts, although cytotrophoblasts also express this enzyme...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2002-08, Vol.87 (8), p.3696-3701
Hauptverfasser:	Hardy, D. B., Yang, K.
Format:	Artikel
Sprache:	eng
Schlagworte:	11-beta-Hydroxysteroid Dehydrogenase Type 2 Biological and medical sciences Cell Differentiation - physiology Cells, Cultured Chorionic Gonadotropin - secretion Diseases of mother, fetus and pregnancy Gynecology. Andrology. Obstetrics Humans Hydroxysteroid Dehydrogenases - analysis Hydroxysteroid Dehydrogenases - biosynthesis Hypoxia - metabolism Medical sciences Pregnancy. Fetus. Placenta Trophoblasts - cytology Trophoblasts - enzymology Trophoblasts - secretion
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