Hypoxia suppresses runx2 independent of modeled microgravity

Bone loss is a consequence of skeletal unloading as seen in bed rest and space flight. Unloading decreases oxygenation and osteoblast differentiation/function in bone. Previously we demonstrated that simulation of unloading in vitro, by culturing differentiating mouse osteoblasts in a horizontal rot...

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Veröffentlicht in:	Journal of cellular physiology 2004-08, Vol.200 (2), p.169-176
Hauptverfasser:	Ontiveros, Christopher, Irwin, Regina, Wiseman, Robert W., McCabe, Laura R.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Cell Culture Techniques - methods Cell Hypoxia Clone Cells Core Binding Factor Alpha 1 Subunit Gene Expression Regulation Gravity, Altered Mice Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Osteoblasts - cytology Osteoblasts - physiology Phosphoric Monoester Hydrolases - genetics Phosphoric Monoester Hydrolases - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Space life sciences Time Factors Transcription Factors - genetics Transcription Factors - metabolism Up-Regulation Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism Weightlessness Simulation
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