Different cytokine levels in thrombolysis patients as predictors for clinical outcome

Thrombolytic therapy not always improves clinical outcome in ischemic stroke patients. This could cause lymphomonocyte accumulation in the infarcted brain area. These produce an excessive amount of proinflammatory cytokines, such as IL‐1beta, IL‐6 and TNF‐alfa. The aim of our study was to determine ILs levels in fibrinolytic therapy treated patients, compared with healthy controls and to evaluate if the varying levels can predictors of neurological outcome. Eighteen patients underwent thrombolytic treatment with t‐PA within 3 h. Plasma levels of IL‐1beta, IL‐6, TNF‐alfa and IL‐10 were determined by ELISA method before and within 24 h after t‐PA infusion and compared with controls. Significantly higher levels of IL‐1beta and Il‐6 emerged in stroke patients before treatment compared with the control group (P