Hyperbaric oxygen therapy prevents vascular derangement during zymosan-induced multiple-organ-failure syndrome
This study investigated the effects of hyperbaric oxygen (HBO) therapy on the cardiovascular alteration (e.g. mean arterial pressure, vascular reactivity of thoracic aorta rings changes) caused by zymosan in rats. Rats. University research laboratory. We investigated the effects of HBO therapy (2 AT...
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| Veröffentlicht in: | Intensive care medicine 2004-06, Vol.30 (6), p.1175-1181 |
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| creator | IMPERATORE, Francesco CUZZOCREA, Salvatore LUONGO, Carlo LIGUORI, Giovanni SCAFURO, Antonella DE ANGELIS, Antonella ROSSI, Francesco CAPUTI, Achille P FILIPPELLI, Amelia |
| description | This study investigated the effects of hyperbaric oxygen (HBO) therapy on the cardiovascular alteration (e.g. mean arterial pressure, vascular reactivity of thoracic aorta rings changes) caused by zymosan in rats.
Rats.
University research laboratory.
We investigated the effects of HBO therapy (2 ATA at the fourth and eleventh hours after study onset) on the cardiovascular alteration caused by zymosan (500 mg/kg, administered i.p. as a suspension in saline) in rats. Cardiovascular alterations were assessed 18 h after administration of zymosan and/or HBO therapy.
Treatment of rats with HBO therapy attenuated the vasoplegic response to zymosan. In fact, the analysis of arterial pressure curves revealed no signs of vasoplegic shock. The aorta rings of animals treated with zymosan and HBO had a significantly increased contraction to norepinephrine (NE) and endothelin-1 (ET-1) and dilation to acetylcholine (ACh) compared with the zymosan group. The HBO therapy also attenuated the increase of malondialdehyde (MDA) levels caused by zymosan in the aorta. Immunohistochemical analysis for nitrotyrosine and for iNOS revealed positive staining in the aorta from zymosan-treated rats. The degree of staining for nitrotyrosine and iNOS was markedly reduced in tissue sections obtained from zymosan-rats treated with HBO therapy.
This study provides the first evidence that HBO therapy attenuates the degree of zymosan-induced cardiovascular derangement in the rat. |
| doi_str_mv | 10.1007/s00134-003-2138-8 |
| format | Article |
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Rats.
University research laboratory.
We investigated the effects of HBO therapy (2 ATA at the fourth and eleventh hours after study onset) on the cardiovascular alteration caused by zymosan (500 mg/kg, administered i.p. as a suspension in saline) in rats. Cardiovascular alterations were assessed 18 h after administration of zymosan and/or HBO therapy.
Treatment of rats with HBO therapy attenuated the vasoplegic response to zymosan. In fact, the analysis of arterial pressure curves revealed no signs of vasoplegic shock. The aorta rings of animals treated with zymosan and HBO had a significantly increased contraction to norepinephrine (NE) and endothelin-1 (ET-1) and dilation to acetylcholine (ACh) compared with the zymosan group. The HBO therapy also attenuated the increase of malondialdehyde (MDA) levels caused by zymosan in the aorta. Immunohistochemical analysis for nitrotyrosine and for iNOS revealed positive staining in the aorta from zymosan-treated rats. The degree of staining for nitrotyrosine and iNOS was markedly reduced in tissue sections obtained from zymosan-rats treated with HBO therapy.
This study provides the first evidence that HBO therapy attenuates the degree of zymosan-induced cardiovascular derangement in the rat.</description><identifier>ISSN: 0342-4642</identifier><identifier>EISSN: 1432-1238</identifier><identifier>DOI: 10.1007/s00134-003-2138-8</identifier><identifier>PMID: 14963645</identifier><identifier>CODEN: ICMED9</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Analysis of Variance ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Animals ; Aorta - metabolism ; Biological and medical sciences ; Endothelium, Vascular - physiology ; Hyperbaric Oxygenation ; Immunohistochemistry ; Intensive care medicine ; Male ; Malondialdehyde - metabolism ; Medical sciences ; Multiple Organ Failure - physiopathology ; Multiple Organ Failure - therapy ; Nitric Oxide Synthase - metabolism ; Nitric Oxide Synthase Type II ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Tyrosine - analogs & derivatives ; Tyrosine - metabolism ; Vascular Diseases - prevention & control ; Vasodilation - physiology ; Zymosan</subject><ispartof>Intensive care medicine, 2004-06, Vol.30 (6), p.1175-1181</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright Springer-Verlag 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-8864d3b45ecbecb4a8c9648076103b1235a15eaae27b2ad150de57fe0dfabf5b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15803096$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14963645$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>IMPERATORE, Francesco</creatorcontrib><creatorcontrib>CUZZOCREA, Salvatore</creatorcontrib><creatorcontrib>LUONGO, Carlo</creatorcontrib><creatorcontrib>LIGUORI, Giovanni</creatorcontrib><creatorcontrib>SCAFURO, Antonella</creatorcontrib><creatorcontrib>DE ANGELIS, Antonella</creatorcontrib><creatorcontrib>ROSSI, Francesco</creatorcontrib><creatorcontrib>CAPUTI, Achille P</creatorcontrib><creatorcontrib>FILIPPELLI, Amelia</creatorcontrib><title>Hyperbaric oxygen therapy prevents vascular derangement during zymosan-induced multiple-organ-failure syndrome</title><title>Intensive care medicine</title><addtitle>Intensive Care Med</addtitle><description>This study investigated the effects of hyperbaric oxygen (HBO) therapy on the cardiovascular alteration (e.g. mean arterial pressure, vascular reactivity of thoracic aorta rings changes) caused by zymosan in rats.
Rats.
University research laboratory.
We investigated the effects of HBO therapy (2 ATA at the fourth and eleventh hours after study onset) on the cardiovascular alteration caused by zymosan (500 mg/kg, administered i.p. as a suspension in saline) in rats. Cardiovascular alterations were assessed 18 h after administration of zymosan and/or HBO therapy.
Treatment of rats with HBO therapy attenuated the vasoplegic response to zymosan. In fact, the analysis of arterial pressure curves revealed no signs of vasoplegic shock. The aorta rings of animals treated with zymosan and HBO had a significantly increased contraction to norepinephrine (NE) and endothelin-1 (ET-1) and dilation to acetylcholine (ACh) compared with the zymosan group. The HBO therapy also attenuated the increase of malondialdehyde (MDA) levels caused by zymosan in the aorta. Immunohistochemical analysis for nitrotyrosine and for iNOS revealed positive staining in the aorta from zymosan-treated rats. The degree of staining for nitrotyrosine and iNOS was markedly reduced in tissue sections obtained from zymosan-rats treated with HBO therapy.
This study provides the first evidence that HBO therapy attenuates the degree of zymosan-induced cardiovascular derangement in the rat.</description><subject>Analysis of Variance</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Animals</subject><subject>Aorta - metabolism</subject><subject>Biological and medical sciences</subject><subject>Endothelium, Vascular - physiology</subject><subject>Hyperbaric Oxygenation</subject><subject>Immunohistochemistry</subject><subject>Intensive care medicine</subject><subject>Male</subject><subject>Malondialdehyde - metabolism</subject><subject>Medical sciences</subject><subject>Multiple Organ Failure - physiopathology</subject><subject>Multiple Organ Failure - therapy</subject><subject>Nitric Oxide Synthase - metabolism</subject><subject>Nitric Oxide Synthase Type II</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Tyrosine - analogs & derivatives</subject><subject>Tyrosine - metabolism</subject><subject>Vascular Diseases - prevention & control</subject><subject>Vasodilation - physiology</subject><subject>Zymosan</subject><issn>0342-4642</issn><issn>1432-1238</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkUtr3TAQhUVpaW6S_oBuiigkOzV6W3cZQvOAQDbNWsjS-NbBlh3JCnV_fRTuhUBAIBh9Z2Z0DkLfGf3FKG0uMqVMSEKpIJwJQ8wntGFScMK4MJ_RhgrJidSSH6HjnJ8q3WjFvqIjJrdaaKk2KN6uM6TWpd7j6d-6g4iXv5DcvOI5wQvEJeMXl30ZXMKhPsQdjLWKQ0l93OH_6zhlF0kfQ_EQ8FiGpZ8HIFPa1XLn-qEkwHmNIU0jnKIvnRsyfDvcJ-jx-vefq1ty_3Bzd3V5T7xQciHGaBlEKxX4th7pjN9qaWijGRVt_Z1yTIFzwJuWu8AUDaCaDmjoXNupVpyg833fOU3PBfJixz57GAYXYSrZNmyrjaaqgj8_gE9TSbHuZjnTnG65oRVie8inKecEnZ1TP7q0WkbtWxJ2n4StSdi3JKypmh-HxqUdIbwrDtZX4OwAVHvd0FVrfZ_fOVUH08q-Asgwk9c</recordid><startdate>20040601</startdate><enddate>20040601</enddate><creator>IMPERATORE, Francesco</creator><creator>CUZZOCREA, Salvatore</creator><creator>LUONGO, Carlo</creator><creator>LIGUORI, Giovanni</creator><creator>SCAFURO, Antonella</creator><creator>DE ANGELIS, Antonella</creator><creator>ROSSI, Francesco</creator><creator>CAPUTI, Achille P</creator><creator>FILIPPELLI, Amelia</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20040601</creationdate><title>Hyperbaric oxygen therapy prevents vascular derangement during zymosan-induced multiple-organ-failure syndrome</title><author>IMPERATORE, Francesco ; CUZZOCREA, Salvatore ; LUONGO, Carlo ; LIGUORI, Giovanni ; SCAFURO, Antonella ; DE ANGELIS, Antonella ; ROSSI, Francesco ; CAPUTI, Achille P ; FILIPPELLI, Amelia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-8864d3b45ecbecb4a8c9648076103b1235a15eaae27b2ad150de57fe0dfabf5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Analysis of Variance</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Animals</topic><topic>Aorta - metabolism</topic><topic>Biological and medical sciences</topic><topic>Endothelium, Vascular - physiology</topic><topic>Hyperbaric Oxygenation</topic><topic>Immunohistochemistry</topic><topic>Intensive care medicine</topic><topic>Male</topic><topic>Malondialdehyde - metabolism</topic><topic>Medical sciences</topic><topic>Multiple Organ Failure - physiopathology</topic><topic>Multiple Organ Failure - therapy</topic><topic>Nitric Oxide Synthase - metabolism</topic><topic>Nitric Oxide Synthase Type II</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Tyrosine - analogs & derivatives</topic><topic>Tyrosine - metabolism</topic><topic>Vascular Diseases - prevention & control</topic><topic>Vasodilation - physiology</topic><topic>Zymosan</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>IMPERATORE, Francesco</creatorcontrib><creatorcontrib>CUZZOCREA, Salvatore</creatorcontrib><creatorcontrib>LUONGO, Carlo</creatorcontrib><creatorcontrib>LIGUORI, Giovanni</creatorcontrib><creatorcontrib>SCAFURO, Antonella</creatorcontrib><creatorcontrib>DE ANGELIS, Antonella</creatorcontrib><creatorcontrib>ROSSI, Francesco</creatorcontrib><creatorcontrib>CAPUTI, Achille P</creatorcontrib><creatorcontrib>FILIPPELLI, Amelia</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Intensive care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>IMPERATORE, Francesco</au><au>CUZZOCREA, Salvatore</au><au>LUONGO, Carlo</au><au>LIGUORI, Giovanni</au><au>SCAFURO, Antonella</au><au>DE ANGELIS, Antonella</au><au>ROSSI, Francesco</au><au>CAPUTI, Achille P</au><au>FILIPPELLI, Amelia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hyperbaric oxygen therapy prevents vascular derangement during zymosan-induced multiple-organ-failure syndrome</atitle><jtitle>Intensive care medicine</jtitle><addtitle>Intensive Care Med</addtitle><date>2004-06-01</date><risdate>2004</risdate><volume>30</volume><issue>6</issue><spage>1175</spage><epage>1181</epage><pages>1175-1181</pages><issn>0342-4642</issn><eissn>1432-1238</eissn><coden>ICMED9</coden><abstract>This study investigated the effects of hyperbaric oxygen (HBO) therapy on the cardiovascular alteration (e.g. mean arterial pressure, vascular reactivity of thoracic aorta rings changes) caused by zymosan in rats.
Rats.
University research laboratory.
We investigated the effects of HBO therapy (2 ATA at the fourth and eleventh hours after study onset) on the cardiovascular alteration caused by zymosan (500 mg/kg, administered i.p. as a suspension in saline) in rats. Cardiovascular alterations were assessed 18 h after administration of zymosan and/or HBO therapy.
Treatment of rats with HBO therapy attenuated the vasoplegic response to zymosan. In fact, the analysis of arterial pressure curves revealed no signs of vasoplegic shock. The aorta rings of animals treated with zymosan and HBO had a significantly increased contraction to norepinephrine (NE) and endothelin-1 (ET-1) and dilation to acetylcholine (ACh) compared with the zymosan group. The HBO therapy also attenuated the increase of malondialdehyde (MDA) levels caused by zymosan in the aorta. Immunohistochemical analysis for nitrotyrosine and for iNOS revealed positive staining in the aorta from zymosan-treated rats. The degree of staining for nitrotyrosine and iNOS was markedly reduced in tissue sections obtained from zymosan-rats treated with HBO therapy.
This study provides the first evidence that HBO therapy attenuates the degree of zymosan-induced cardiovascular derangement in the rat.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><pub>Springer</pub><pmid>14963645</pmid><doi>10.1007/s00134-003-2138-8</doi><tpages>7</tpages></addata></record> |
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| ispartof | Intensive care medicine, 2004-06, Vol.30 (6), p.1175-1181 |
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| subjects | Analysis of Variance Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Aorta - metabolism Biological and medical sciences Endothelium, Vascular - physiology Hyperbaric Oxygenation Immunohistochemistry Intensive care medicine Male Malondialdehyde - metabolism Medical sciences Multiple Organ Failure - physiopathology Multiple Organ Failure - therapy Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type II Random Allocation Rats Rats, Sprague-Dawley Tyrosine - analogs & derivatives Tyrosine - metabolism Vascular Diseases - prevention & control Vasodilation - physiology Zymosan |
| title | Hyperbaric oxygen therapy prevents vascular derangement during zymosan-induced multiple-organ-failure syndrome |
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