Clinical value of attenuation correction in stress-only Tc-99m sestamibi SPECT imaging
Attenuation artifact remains a substantial limitation to confident interpretation of images and reduces laboratory efficiency by requiring comparison of stress and rest image sets. Attenuation-corrected stress-only imaging has the potential to ameliorate these limitations. Ten experienced nuclear ca...
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| Veröffentlicht in: | Journal of nuclear cardiology 2004-05, Vol.11 (3), p.273-281 |
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| creator | Heller, Gary V Bateman, Timothy M Johnson, Lynne L Cullom, S.James Case, James A Galt, James R Garcia, Ernest V Haddock, Keith Moutray, Kelly L Poston, Carlos Botvinick, Eli H Fish, Matthews B Follansbee, William P Hayes, Sean Iskandrian, Ami E Mahmarian, John J Vandecker, William |
| description | Attenuation artifact remains a substantial limitation to confident interpretation of images and reduces laboratory efficiency by requiring comparison of stress and rest image sets. Attenuation-corrected stress-only imaging has the potential to ameliorate these limitations.
Ten experienced nuclear cardiologists independently interpreted 90 stress-only electrocardiography (ECG)–gated technetium 99m sestamibi images in a sequential fashion: myocardial perfusion imaging (MPI) alone, MPI plus ECG-gated data, and attenuation-corrected MPI with ECG-gated data. Images were interpreted for diagnostic certainty (normal, probably normal, equivocal, probably abnormal, abnormal, and perceived need for rest imaging). With stress MPI data alone, only 37% of studies were interpreted as definitely normal or abnormal, with a very high perceived need for rest imaging (77%). The addition of gated data did not alter the interpretations. However, attenuation-corrected data significantly increased the number of studies characterized as definitely normal or abnormal (84%,
P < .005) and significantly reduced the perceived need for rest imaging (43%,
P < .005). These results were confirmed by use of a nonsequential consensus interpretation of three readers.
Attenuation correction applied to studies with stress-only Tc-99m ECG-gated single photon emission computed tomography images significantly increases the ability to interpret studies as definitely normal or abnormal and reduces the need for rest imaging. These findings may improve laboratory efficiency and diagnostic accuracy. |
| doi_str_mv | 10.1016/j.nuclcard.2004.03.005 |
| format | Article |
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Ten experienced nuclear cardiologists independently interpreted 90 stress-only electrocardiography (ECG)–gated technetium 99m sestamibi images in a sequential fashion: myocardial perfusion imaging (MPI) alone, MPI plus ECG-gated data, and attenuation-corrected MPI with ECG-gated data. Images were interpreted for diagnostic certainty (normal, probably normal, equivocal, probably abnormal, abnormal, and perceived need for rest imaging). With stress MPI data alone, only 37% of studies were interpreted as definitely normal or abnormal, with a very high perceived need for rest imaging (77%). The addition of gated data did not alter the interpretations. However, attenuation-corrected data significantly increased the number of studies characterized as definitely normal or abnormal (84%,
P < .005) and significantly reduced the perceived need for rest imaging (43%,
P < .005). These results were confirmed by use of a nonsequential consensus interpretation of three readers.
Attenuation correction applied to studies with stress-only Tc-99m ECG-gated single photon emission computed tomography images significantly increases the ability to interpret studies as definitely normal or abnormal and reduces the need for rest imaging. These findings may improve laboratory efficiency and diagnostic accuracy.</description><identifier>ISSN: 1071-3581</identifier><identifier>EISSN: 1532-6551</identifier><identifier>DOI: 10.1016/j.nuclcard.2004.03.005</identifier><identifier>PMID: 15173774</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; attenuation correction ; Coronary Artery Disease - diagnostic imaging ; Coronary Artery Disease - etiology ; electrocardiography gating ; Exercise Test ; Female ; Gated Blood-Pool Imaging - methods ; Humans ; Image Enhancement ; Image Interpretation, Computer-Assisted - methods ; Male ; Medical imaging ; Myocardial perfusion imaging ; Obesity - complications ; Obesity - diagnostic imaging ; Radiopharmaceuticals ; Reproducibility of Results ; Sensitivity and Specificity ; single photon emission computed tomography ; Single-Blind Method ; Technetium Tc 99m Sestamibi ; Tomography, Emission-Computed, Single-Photon - methods</subject><ispartof>Journal of nuclear cardiology, 2004-05, Vol.11 (3), p.273-281</ispartof><rights>2004 American Society of Nuclear Cardiology</rights><rights>American Society of Nuclear Cardiology 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-69d56287300fa5f6fe39aad4d8833440db7e30c8612fc56cc96e4785673db6973</citedby><cites>FETCH-LOGICAL-c391t-69d56287300fa5f6fe39aad4d8833440db7e30c8612fc56cc96e4785673db6973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15173774$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Heller, Gary V</creatorcontrib><creatorcontrib>Bateman, Timothy M</creatorcontrib><creatorcontrib>Johnson, Lynne L</creatorcontrib><creatorcontrib>Cullom, S.James</creatorcontrib><creatorcontrib>Case, James A</creatorcontrib><creatorcontrib>Galt, James R</creatorcontrib><creatorcontrib>Garcia, Ernest V</creatorcontrib><creatorcontrib>Haddock, Keith</creatorcontrib><creatorcontrib>Moutray, Kelly L</creatorcontrib><creatorcontrib>Poston, Carlos</creatorcontrib><creatorcontrib>Botvinick, Eli H</creatorcontrib><creatorcontrib>Fish, Matthews B</creatorcontrib><creatorcontrib>Follansbee, William P</creatorcontrib><creatorcontrib>Hayes, Sean</creatorcontrib><creatorcontrib>Iskandrian, Ami E</creatorcontrib><creatorcontrib>Mahmarian, John J</creatorcontrib><creatorcontrib>Vandecker, William</creatorcontrib><title>Clinical value of attenuation correction in stress-only Tc-99m sestamibi SPECT imaging</title><title>Journal of nuclear cardiology</title><addtitle>J Nucl Cardiol</addtitle><description>Attenuation artifact remains a substantial limitation to confident interpretation of images and reduces laboratory efficiency by requiring comparison of stress and rest image sets. Attenuation-corrected stress-only imaging has the potential to ameliorate these limitations.
Ten experienced nuclear cardiologists independently interpreted 90 stress-only electrocardiography (ECG)–gated technetium 99m sestamibi images in a sequential fashion: myocardial perfusion imaging (MPI) alone, MPI plus ECG-gated data, and attenuation-corrected MPI with ECG-gated data. Images were interpreted for diagnostic certainty (normal, probably normal, equivocal, probably abnormal, abnormal, and perceived need for rest imaging). With stress MPI data alone, only 37% of studies were interpreted as definitely normal or abnormal, with a very high perceived need for rest imaging (77%). The addition of gated data did not alter the interpretations. However, attenuation-corrected data significantly increased the number of studies characterized as definitely normal or abnormal (84%,
P < .005) and significantly reduced the perceived need for rest imaging (43%,
P < .005). These results were confirmed by use of a nonsequential consensus interpretation of three readers.
Attenuation correction applied to studies with stress-only Tc-99m ECG-gated single photon emission computed tomography images significantly increases the ability to interpret studies as definitely normal or abnormal and reduces the need for rest imaging. These findings may improve laboratory efficiency and diagnostic accuracy.</description><subject>Adult</subject><subject>Aged</subject><subject>attenuation correction</subject><subject>Coronary Artery Disease - diagnostic imaging</subject><subject>Coronary Artery Disease - etiology</subject><subject>electrocardiography gating</subject><subject>Exercise Test</subject><subject>Female</subject><subject>Gated Blood-Pool Imaging - methods</subject><subject>Humans</subject><subject>Image Enhancement</subject><subject>Image Interpretation, Computer-Assisted - methods</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Myocardial perfusion imaging</subject><subject>Obesity - complications</subject><subject>Obesity - diagnostic imaging</subject><subject>Radiopharmaceuticals</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>single photon emission computed tomography</subject><subject>Single-Blind Method</subject><subject>Technetium Tc 99m Sestamibi</subject><subject>Tomography, Emission-Computed, Single-Photon - methods</subject><issn>1071-3581</issn><issn>1532-6551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkEtr3DAURkVpaR7tXwiii-7sXI0sydqlDEkbCLTQabdCI10HDbaUSnYg_z6azoRCN1ndb3Hu6xBywaBlwOTlro2LG53Nvl0BdC3wFkC8IadM8FUjhWBvawbFGi56dkLOStkBgOZavycnTDDFlepOye_1GGJwdqSPdlyQpoHaeca42DmkSF3KGd3fGCItc8ZSmhTHJ7pxjdYTLVhmO4VtoD9_XK83NEz2PsT7D-TdYMeCH4_1nPy6ud6svzV337_err_cNY5rNjdSeyFXveIAgxWDHJBra33n-57zrgO_VcjB9ZKtBiekc1pip3ohFfdbqRU_J58Pcx9y-rPUW8wUisNxtBHTUoxiWlZcV_DTf-AuLTnW24zinex70HtIHiCXUykZB_OQ60P5yTAwe-1mZ160m712A9xU7bXx4jh92U7o_7UdPVfg6gBglfEYMJviAkaHPuz9Gp_CazueAUM5leQ</recordid><startdate>20040501</startdate><enddate>20040501</enddate><creator>Heller, Gary V</creator><creator>Bateman, Timothy M</creator><creator>Johnson, Lynne L</creator><creator>Cullom, S.James</creator><creator>Case, James A</creator><creator>Galt, James R</creator><creator>Garcia, Ernest V</creator><creator>Haddock, Keith</creator><creator>Moutray, Kelly L</creator><creator>Poston, Carlos</creator><creator>Botvinick, Eli H</creator><creator>Fish, Matthews B</creator><creator>Follansbee, William P</creator><creator>Hayes, Sean</creator><creator>Iskandrian, Ami E</creator><creator>Mahmarian, John J</creator><creator>Vandecker, William</creator><general>Elsevier Inc</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20040501</creationdate><title>Clinical value of attenuation correction in stress-only Tc-99m sestamibi SPECT imaging</title><author>Heller, Gary V ; Bateman, Timothy M ; Johnson, Lynne L ; Cullom, S.James ; Case, James A ; Galt, James R ; Garcia, Ernest V ; Haddock, Keith ; Moutray, Kelly L ; Poston, Carlos ; Botvinick, Eli H ; Fish, Matthews B ; Follansbee, William P ; Hayes, Sean ; Iskandrian, Ami E ; Mahmarian, John J ; Vandecker, William</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-69d56287300fa5f6fe39aad4d8833440db7e30c8612fc56cc96e4785673db6973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Aged</topic><topic>attenuation correction</topic><topic>Coronary Artery Disease - diagnostic imaging</topic><topic>Coronary Artery Disease - etiology</topic><topic>electrocardiography gating</topic><topic>Exercise Test</topic><topic>Female</topic><topic>Gated Blood-Pool Imaging - methods</topic><topic>Humans</topic><topic>Image Enhancement</topic><topic>Image Interpretation, Computer-Assisted - methods</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Myocardial perfusion imaging</topic><topic>Obesity - complications</topic><topic>Obesity - diagnostic imaging</topic><topic>Radiopharmaceuticals</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>single photon emission computed tomography</topic><topic>Single-Blind Method</topic><topic>Technetium Tc 99m Sestamibi</topic><topic>Tomography, Emission-Computed, Single-Photon - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heller, Gary V</creatorcontrib><creatorcontrib>Bateman, Timothy M</creatorcontrib><creatorcontrib>Johnson, Lynne L</creatorcontrib><creatorcontrib>Cullom, S.James</creatorcontrib><creatorcontrib>Case, James A</creatorcontrib><creatorcontrib>Galt, James R</creatorcontrib><creatorcontrib>Garcia, Ernest V</creatorcontrib><creatorcontrib>Haddock, Keith</creatorcontrib><creatorcontrib>Moutray, Kelly L</creatorcontrib><creatorcontrib>Poston, Carlos</creatorcontrib><creatorcontrib>Botvinick, Eli H</creatorcontrib><creatorcontrib>Fish, Matthews B</creatorcontrib><creatorcontrib>Follansbee, William P</creatorcontrib><creatorcontrib>Hayes, Sean</creatorcontrib><creatorcontrib>Iskandrian, Ami E</creatorcontrib><creatorcontrib>Mahmarian, John J</creatorcontrib><creatorcontrib>Vandecker, William</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of nuclear cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heller, Gary V</au><au>Bateman, Timothy M</au><au>Johnson, Lynne L</au><au>Cullom, S.James</au><au>Case, James A</au><au>Galt, James R</au><au>Garcia, Ernest V</au><au>Haddock, Keith</au><au>Moutray, Kelly L</au><au>Poston, Carlos</au><au>Botvinick, Eli H</au><au>Fish, Matthews B</au><au>Follansbee, William P</au><au>Hayes, Sean</au><au>Iskandrian, Ami E</au><au>Mahmarian, John J</au><au>Vandecker, William</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical value of attenuation correction in stress-only Tc-99m sestamibi SPECT imaging</atitle><jtitle>Journal of nuclear cardiology</jtitle><addtitle>J Nucl Cardiol</addtitle><date>2004-05-01</date><risdate>2004</risdate><volume>11</volume><issue>3</issue><spage>273</spage><epage>281</epage><pages>273-281</pages><issn>1071-3581</issn><eissn>1532-6551</eissn><abstract>Attenuation artifact remains a substantial limitation to confident interpretation of images and reduces laboratory efficiency by requiring comparison of stress and rest image sets. Attenuation-corrected stress-only imaging has the potential to ameliorate these limitations.
Ten experienced nuclear cardiologists independently interpreted 90 stress-only electrocardiography (ECG)–gated technetium 99m sestamibi images in a sequential fashion: myocardial perfusion imaging (MPI) alone, MPI plus ECG-gated data, and attenuation-corrected MPI with ECG-gated data. Images were interpreted for diagnostic certainty (normal, probably normal, equivocal, probably abnormal, abnormal, and perceived need for rest imaging). With stress MPI data alone, only 37% of studies were interpreted as definitely normal or abnormal, with a very high perceived need for rest imaging (77%). The addition of gated data did not alter the interpretations. However, attenuation-corrected data significantly increased the number of studies characterized as definitely normal or abnormal (84%,
P < .005) and significantly reduced the perceived need for rest imaging (43%,
P < .005). These results were confirmed by use of a nonsequential consensus interpretation of three readers.
Attenuation correction applied to studies with stress-only Tc-99m ECG-gated single photon emission computed tomography images significantly increases the ability to interpret studies as definitely normal or abnormal and reduces the need for rest imaging. These findings may improve laboratory efficiency and diagnostic accuracy.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>15173774</pmid><doi>10.1016/j.nuclcard.2004.03.005</doi><tpages>9</tpages></addata></record> |
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| ispartof | Journal of nuclear cardiology, 2004-05, Vol.11 (3), p.273-281 |
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| subjects | Adult Aged attenuation correction Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - etiology electrocardiography gating Exercise Test Female Gated Blood-Pool Imaging - methods Humans Image Enhancement Image Interpretation, Computer-Assisted - methods Male Medical imaging Myocardial perfusion imaging Obesity - complications Obesity - diagnostic imaging Radiopharmaceuticals Reproducibility of Results Sensitivity and Specificity single photon emission computed tomography Single-Blind Method Technetium Tc 99m Sestamibi Tomography, Emission-Computed, Single-Photon - methods |
| title | Clinical value of attenuation correction in stress-only Tc-99m sestamibi SPECT imaging |
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