Optimal low-density lipoprotein is 50 to 70 mg/dl: Lower is better and physiologically normal
The normal low-density lipoprotein (LDL) cholesterol range is 50 to 70 mg/dl for native hunter-gatherers, healthy human neonates, free-living primates, and other wild mammals (all of whom do not develop atherosclerosis). Randomized trial data suggest atherosclerosis progression and coronary heart di...
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Veröffentlicht in: | Journal of the American College of Cardiology 2004-06, Vol.43 (11), p.2142-2146 |
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creator | O'Keefe, James H Cordain, Loren Harris, William H Moe, Richard M Vogel, Robert |
description | The normal low-density lipoprotein (LDL) cholesterol range is 50 to 70 mg/dl for native hunter-gatherers, healthy human neonates, free-living primates, and other wild mammals (all of whom do not develop atherosclerosis). Randomized trial data suggest atherosclerosis progression and coronary heart disease events are minimized when LDL is lowered to |
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Randomized trial data suggest atherosclerosis progression and coronary heart disease events are minimized when LDL is lowered to <70 mg/dl. No major safety concerns have surfaced in studies that lowered LDL to this range of 50 to 70 mg/dl. The current guidelines setting the target LDL at 100 to 115 mg/dl may lead to substantial undertreatment in high-risk individuals.</description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/j.jacc.2004.03.046</identifier><identifier>PMID: 15172426</identifier><identifier>CODEN: JACCDI</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Anticholesteremic Agents - administration & dosage ; Atherosclerosis ; Biological and medical sciences ; Biology ; Cardiology ; Cardiology. 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Vascular system</subject><subject>Cardiovascular disease</subject><subject>Cholesterol</subject><subject>Cholesterol - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Chronic illnesses</subject><subject>Coronary Artery Disease - blood</subject><subject>Coronary Artery Disease - prevention & control</subject><subject>Humans</subject><subject>Low density lipoprotein</subject><subject>Medical sciences</subject><subject>Mortality</subject><subject>Practice Guidelines as Topic</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Statins</subject><subject>Studies</subject><subject>Ultrasonic imaging</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkUFr3DAQhUVpaTZJ_0APRVDam52RZclS6aWEpgks5NIci5ClcSqjtVzL27D_vlqyhdLTDMzH4817hLxlUDNg8mqsR-tc3QC0NfAaWvmCbJgQquJCdy_JBjouKga6OyPnOY8AIBXTr8kZE6xr2kZuyI_7eQ07G2lMT5XHKYf1QGOY07ykFcNEQ6YC6JpoB3T3eOXjJ7pNT7gcDz2ua9ns5On885BDiukxOBvjgU5pKaqX5NVgY8Y3p3lBHm6-fr--rbb33-6uv2wr5KJdK6sGzbnkba9cp8UgGi_QqUFq2WiQ6JiW2rW2A9QKndeN1L31vmVSOVQ9vyAfn3WL6197zKvZhewwRjth2mfTFQElhCzg-__AMe2XqXgzTIBkreIcCvXuRO37HXozLyWi5WD-xlaADyfA5vLvsNjJhfwPp0Cotivc52cOy_O_Ay4mu4CTQx8WdKvxKRgG5timGc2xTXNs0wA3pU3-B9ovkCo</recordid><startdate>20040602</startdate><enddate>20040602</enddate><creator>O'Keefe, James H</creator><creator>Cordain, Loren</creator><creator>Harris, William H</creator><creator>Moe, Richard M</creator><creator>Vogel, Robert</creator><general>Elsevier Inc</general><general>Elsevier Science</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20040602</creationdate><title>Optimal low-density lipoprotein is 50 to 70 mg/dl: Lower is better and physiologically normal</title><author>O'Keefe, James H ; Cordain, Loren ; Harris, William H ; Moe, Richard M ; Vogel, Robert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e354t-a8f933634b8c795f52d5ec8f6962906ec1969c4a70e98ecd9269badd4168ce8b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Anticholesteremic Agents - administration & dosage</topic><topic>Atherosclerosis</topic><topic>Biological and medical sciences</topic><topic>Biology</topic><topic>Cardiology</topic><topic>Cardiology. 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source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ScienceDirect Journals (5 years ago - present); Alma/SFX Local Collection |
subjects | Animals Anticholesteremic Agents - administration & dosage Atherosclerosis Biological and medical sciences Biology Cardiology Cardiology. Vascular system Cardiovascular disease Cholesterol Cholesterol - blood Cholesterol, LDL - blood Chronic illnesses Coronary Artery Disease - blood Coronary Artery Disease - prevention & control Humans Low density lipoprotein Medical sciences Mortality Practice Guidelines as Topic Randomized Controlled Trials as Topic Statins Studies Ultrasonic imaging |
title | Optimal low-density lipoprotein is 50 to 70 mg/dl: Lower is better and physiologically normal |
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