Post-sirolimus-eluting stent restenosis treated with repeat percutaneous intervention : Late angiographic and clinical outcomes
We evaluated the clinical and angiographic outcomes of patients presenting with restenosis after sirolimus-eluting stent (SES) implantation treated with repeated percutaneous intervention. A total of 24 consecutive patients have undergone repeated percutaneous intervention to treat post-SES restenos...
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| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 2004-06, Vol.109 (21), p.2500-2502 |
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| creator | LEMOS, Pedro A VAN MIEGHEM, Carlos A. G SERRUYS, Patrick W ARAMPATZIS, Chourmouzios A HOYE, Angela ONG, Andrew T. L MCFADDEN, Eugene SIANOS, Georgios VAN DER GIESSEN, Willem J DE FEYTER, Pim J VAN DOMBURG, Ron T |
| description | We evaluated the clinical and angiographic outcomes of patients presenting with restenosis after sirolimus-eluting stent (SES) implantation treated with repeated percutaneous intervention.
A total of 24 consecutive patients have undergone repeated percutaneous intervention to treat post-SES restenosis (27 lesions). The restenosis was located within the stent in 93% of lesions. From the 27 lesions, 1 (4%) was re-treated with a bare stent, 3 (11%) were treated with balloon dilatation, and the remaining 23 lesions (85%) were treated with repeated drug-eluting stent implantation (SES in 12 lesions [44%], paclitaxel-eluting stents in 11 lesions [41%]). The event-free survival rate was 70.8% after a median follow-up of 279 days from the post-SES treatment. The overall recurrent restenosis rate was 42.9%. The risk of recurrent restenosis was increased for patients with hypercholesterolemia, previous angioplasty, failed brachytherapy, post-SES restenosis needing early ( |
| doi_str_mv | 10.1161/01.CIR.0000130173.63105.4E |
| format | Article |
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A total of 24 consecutive patients have undergone repeated percutaneous intervention to treat post-SES restenosis (27 lesions). The restenosis was located within the stent in 93% of lesions. From the 27 lesions, 1 (4%) was re-treated with a bare stent, 3 (11%) were treated with balloon dilatation, and the remaining 23 lesions (85%) were treated with repeated drug-eluting stent implantation (SES in 12 lesions [44%], paclitaxel-eluting stents in 11 lesions [41%]). The event-free survival rate was 70.8% after a median follow-up of 279 days from the post-SES treatment. The overall recurrent restenosis rate was 42.9%. The risk of recurrent restenosis was increased for patients with hypercholesterolemia, previous angioplasty, failed brachytherapy, post-SES restenosis needing early (<6 months) treatment, and post-SES restenosis treated with balloon dilatation. The recurrent restenosis rate of originally de novo lesions re-treated with drug-eluting stents was 18.2%.
Even though de novo lesions treated with SES at baseline and re-treated with drug-eluting stents had reasonably better outcomes than other lesion types and strategies, our study shows that the treatment of post-SES restenosis is currently suboptimal and warrants further investigation.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/01.CIR.0000130173.63105.4E</identifier><identifier>PMID: 15148279</identifier><identifier>CODEN: CIRCAZ</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Aged ; Angioplasty, Balloon, Coronary ; Biological and medical sciences ; Blood and lymphatic vessels ; Brachytherapy ; Cardiology. Vascular system ; Cohort Studies ; Combined Modality Therapy ; Coronary Restenosis - diagnostic imaging ; Coronary Restenosis - epidemiology ; Coronary Restenosis - therapy ; Coronary Stenosis - drug therapy ; Coronary Stenosis - radiotherapy ; Coronary Stenosis - therapy ; Disease-Free Survival ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Drug Implants ; Female ; Follow-Up Studies ; Humans ; Hypercholesterolemia - complications ; Incidence ; Male ; Medical sciences ; Middle Aged ; Paclitaxel - administration & dosage ; Paclitaxel - therapeutic use ; Radiography ; Recurrence ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Sirolimus - administration & dosage ; Sirolimus - therapeutic use ; Stents ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Treatment Outcome ; Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels</subject><ispartof>Circulation (New York, N.Y.), 2004-06, Vol.109 (21), p.2500-2502</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c331t-6e6d43cd183f21940b11731bf5a06183f413f56302c6e1c3caa9f2176118926e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16607463$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15148279$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LEMOS, Pedro A</creatorcontrib><creatorcontrib>VAN MIEGHEM, Carlos A. G</creatorcontrib><creatorcontrib>SERRUYS, Patrick W</creatorcontrib><creatorcontrib>ARAMPATZIS, Chourmouzios A</creatorcontrib><creatorcontrib>HOYE, Angela</creatorcontrib><creatorcontrib>ONG, Andrew T. L</creatorcontrib><creatorcontrib>MCFADDEN, Eugene</creatorcontrib><creatorcontrib>SIANOS, Georgios</creatorcontrib><creatorcontrib>VAN DER GIESSEN, Willem J</creatorcontrib><creatorcontrib>DE FEYTER, Pim J</creatorcontrib><creatorcontrib>VAN DOMBURG, Ron T</creatorcontrib><title>Post-sirolimus-eluting stent restenosis treated with repeat percutaneous intervention : Late angiographic and clinical outcomes</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>We evaluated the clinical and angiographic outcomes of patients presenting with restenosis after sirolimus-eluting stent (SES) implantation treated with repeated percutaneous intervention.
A total of 24 consecutive patients have undergone repeated percutaneous intervention to treat post-SES restenosis (27 lesions). The restenosis was located within the stent in 93% of lesions. From the 27 lesions, 1 (4%) was re-treated with a bare stent, 3 (11%) were treated with balloon dilatation, and the remaining 23 lesions (85%) were treated with repeated drug-eluting stent implantation (SES in 12 lesions [44%], paclitaxel-eluting stents in 11 lesions [41%]). The event-free survival rate was 70.8% after a median follow-up of 279 days from the post-SES treatment. The overall recurrent restenosis rate was 42.9%. The risk of recurrent restenosis was increased for patients with hypercholesterolemia, previous angioplasty, failed brachytherapy, post-SES restenosis needing early (<6 months) treatment, and post-SES restenosis treated with balloon dilatation. The recurrent restenosis rate of originally de novo lesions re-treated with drug-eluting stents was 18.2%.
Even though de novo lesions treated with SES at baseline and re-treated with drug-eluting stents had reasonably better outcomes than other lesion types and strategies, our study shows that the treatment of post-SES restenosis is currently suboptimal and warrants further investigation.</description><subject>Aged</subject><subject>Angioplasty, Balloon, Coronary</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Brachytherapy</subject><subject>Cardiology. Vascular system</subject><subject>Cohort Studies</subject><subject>Combined Modality Therapy</subject><subject>Coronary Restenosis - diagnostic imaging</subject><subject>Coronary Restenosis - epidemiology</subject><subject>Coronary Restenosis - therapy</subject><subject>Coronary Stenosis - drug therapy</subject><subject>Coronary Stenosis - radiotherapy</subject><subject>Coronary Stenosis - therapy</subject><subject>Disease-Free Survival</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Drug Implants</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Hypercholesterolemia - complications</subject><subject>Incidence</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Paclitaxel - administration & dosage</subject><subject>Paclitaxel - therapeutic use</subject><subject>Radiography</subject><subject>Recurrence</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><subject>Sirolimus - administration & dosage</subject><subject>Sirolimus - therapeutic use</subject><subject>Stents</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Treatment Outcome</subject><subject>Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkF1LwzAUhoMobn78BQmC3rXmNGnaeidjfsBAEb0OWZpukbapSap45V83c4Pl5nAOz5vkPAhdAkkBONwQSGdPrymJByiBgqacAslTNj9AU8gzlrCcVodoGoEqKWiWTdCJ9x-x5bTIj9EEcmBlVlRT9PtifUi8cbY13egT3Y7B9Cvsg-4DdnpTrTceB6dl0DX-NmEd50Ps8KCdGoPstR09Nn3Q7iumjO3xLV5EGst-ZezKyWFtVGxqrFrTGyVbbMegbKf9GTpqZOv1-a6eovf7-dvsMVk8PzzN7haJohRCwjWvGVU1lLTJoGJkCXFvWDa5JHwzZECbnFOSKa5BUSVlFcGCA5RVxjU9RdfbewdnP8e4luiMV7ptt78XBVS8hDKL4O0WVM5673QjBmc66X4EELHRLwiIqF_s9Yt__YLNY_hi98q47HS9j-58R-BqB0gfNTRO9sr4Pcc5KRin9A9rkZB4</recordid><startdate>20040601</startdate><enddate>20040601</enddate><creator>LEMOS, Pedro A</creator><creator>VAN MIEGHEM, Carlos A. G</creator><creator>SERRUYS, Patrick W</creator><creator>ARAMPATZIS, Chourmouzios A</creator><creator>HOYE, Angela</creator><creator>ONG, Andrew T. L</creator><creator>MCFADDEN, Eugene</creator><creator>SIANOS, Georgios</creator><creator>VAN DER GIESSEN, Willem J</creator><creator>DE FEYTER, Pim J</creator><creator>VAN DOMBURG, Ron T</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040601</creationdate><title>Post-sirolimus-eluting stent restenosis treated with repeat percutaneous intervention : Late angiographic and clinical outcomes</title><author>LEMOS, Pedro A ; VAN MIEGHEM, Carlos A. G ; SERRUYS, Patrick W ; ARAMPATZIS, Chourmouzios A ; HOYE, Angela ; ONG, Andrew T. L ; MCFADDEN, Eugene ; SIANOS, Georgios ; VAN DER GIESSEN, Willem J ; DE FEYTER, Pim J ; VAN DOMBURG, Ron T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c331t-6e6d43cd183f21940b11731bf5a06183f413f56302c6e1c3caa9f2176118926e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Aged</topic><topic>Angioplasty, Balloon, Coronary</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Brachytherapy</topic><topic>Cardiology. Vascular system</topic><topic>Cohort Studies</topic><topic>Combined Modality Therapy</topic><topic>Coronary Restenosis - diagnostic imaging</topic><topic>Coronary Restenosis - epidemiology</topic><topic>Coronary Restenosis - therapy</topic><topic>Coronary Stenosis - drug therapy</topic><topic>Coronary Stenosis - radiotherapy</topic><topic>Coronary Stenosis - therapy</topic><topic>Disease-Free Survival</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>Drug Implants</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Hypercholesterolemia - complications</topic><topic>Incidence</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Paclitaxel - administration & dosage</topic><topic>Paclitaxel - therapeutic use</topic><topic>Radiography</topic><topic>Recurrence</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>Sirolimus - administration & dosage</topic><topic>Sirolimus - therapeutic use</topic><topic>Stents</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Treatment Outcome</topic><topic>Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LEMOS, Pedro A</creatorcontrib><creatorcontrib>VAN MIEGHEM, Carlos A. G</creatorcontrib><creatorcontrib>SERRUYS, Patrick W</creatorcontrib><creatorcontrib>ARAMPATZIS, Chourmouzios A</creatorcontrib><creatorcontrib>HOYE, Angela</creatorcontrib><creatorcontrib>ONG, Andrew T. L</creatorcontrib><creatorcontrib>MCFADDEN, Eugene</creatorcontrib><creatorcontrib>SIANOS, Georgios</creatorcontrib><creatorcontrib>VAN DER GIESSEN, Willem J</creatorcontrib><creatorcontrib>DE FEYTER, Pim J</creatorcontrib><creatorcontrib>VAN DOMBURG, Ron T</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LEMOS, Pedro A</au><au>VAN MIEGHEM, Carlos A. G</au><au>SERRUYS, Patrick W</au><au>ARAMPATZIS, Chourmouzios A</au><au>HOYE, Angela</au><au>ONG, Andrew T. L</au><au>MCFADDEN, Eugene</au><au>SIANOS, Georgios</au><au>VAN DER GIESSEN, Willem J</au><au>DE FEYTER, Pim J</au><au>VAN DOMBURG, Ron T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Post-sirolimus-eluting stent restenosis treated with repeat percutaneous intervention : Late angiographic and clinical outcomes</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>2004-06-01</date><risdate>2004</risdate><volume>109</volume><issue>21</issue><spage>2500</spage><epage>2502</epage><pages>2500-2502</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><coden>CIRCAZ</coden><abstract>We evaluated the clinical and angiographic outcomes of patients presenting with restenosis after sirolimus-eluting stent (SES) implantation treated with repeated percutaneous intervention.
A total of 24 consecutive patients have undergone repeated percutaneous intervention to treat post-SES restenosis (27 lesions). The restenosis was located within the stent in 93% of lesions. From the 27 lesions, 1 (4%) was re-treated with a bare stent, 3 (11%) were treated with balloon dilatation, and the remaining 23 lesions (85%) were treated with repeated drug-eluting stent implantation (SES in 12 lesions [44%], paclitaxel-eluting stents in 11 lesions [41%]). The event-free survival rate was 70.8% after a median follow-up of 279 days from the post-SES treatment. The overall recurrent restenosis rate was 42.9%. The risk of recurrent restenosis was increased for patients with hypercholesterolemia, previous angioplasty, failed brachytherapy, post-SES restenosis needing early (<6 months) treatment, and post-SES restenosis treated with balloon dilatation. The recurrent restenosis rate of originally de novo lesions re-treated with drug-eluting stents was 18.2%.
Even though de novo lesions treated with SES at baseline and re-treated with drug-eluting stents had reasonably better outcomes than other lesion types and strategies, our study shows that the treatment of post-SES restenosis is currently suboptimal and warrants further investigation.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>15148279</pmid><doi>10.1161/01.CIR.0000130173.63105.4E</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-7322 |
| ispartof | Circulation (New York, N.Y.), 2004-06, Vol.109 (21), p.2500-2502 |
| issn | 0009-7322 1524-4539 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71968182 |
| source | MEDLINE; American Heart Association Journals; EZB-FREE-00999 freely available EZB journals; Journals@Ovid Complete |
| subjects | Aged Angioplasty, Balloon, Coronary Biological and medical sciences Blood and lymphatic vessels Brachytherapy Cardiology. Vascular system Cohort Studies Combined Modality Therapy Coronary Restenosis - diagnostic imaging Coronary Restenosis - epidemiology Coronary Restenosis - therapy Coronary Stenosis - drug therapy Coronary Stenosis - radiotherapy Coronary Stenosis - therapy Disease-Free Survival Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Drug Implants Female Follow-Up Studies Humans Hypercholesterolemia - complications Incidence Male Medical sciences Middle Aged Paclitaxel - administration & dosage Paclitaxel - therapeutic use Radiography Recurrence Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Sirolimus - administration & dosage Sirolimus - therapeutic use Stents Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Treatment Outcome Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels |
| title | Post-sirolimus-eluting stent restenosis treated with repeat percutaneous intervention : Late angiographic and clinical outcomes |
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