Analysis of the vitamin D system in basal cell carcinomas (BCCs)

Using real-time PCR (LightCycler) and immunohistochemistry, we have analyzed expression of key components of the vitamin D system in basal cell carcinomas (BCCs) and normal human skin (NS). Increased VDR-immunoreactivity was demonstrated in BCCs using a streptavidin-peroxidase technique. RNA express...

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Veröffentlicht in:	Laboratory investigation 2004-06, Vol.84 (6), p.693-702
Hauptverfasser:	Mitschele, Tanja, Diesel, Britta, Friedrich, Michael, Meineke, Viktor, Maas, Ruth M, Gärtner, Barbara C, Kamradt, Jörn, Meese, Eckart, Tilgen, Wolfgang, Reichrath, Jörg
Format:	Artikel
Sprache:	eng
Schlagworte:	1,25-dihydroxyvitamin D-24-hydroxylase 25-hydroxyvitamin D-1α-hydroxylase 25-Hydroxyvitamin D3 1-alpha-Hydroxylase - genetics Alternative Splicing basal cell carcinoma Base Sequence Biological and medical sciences Biotechnology Carcinoma, Basal Cell - genetics Carcinoma, Basal Cell - metabolism Case-Control Studies Cholestanetriol 26-Monooxygenase Cytochrome P-450 Enzyme System - genetics Dermatology Female Fundamental and applied biological sciences. Psychology Humans Immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Laboratory Medicine Male Medical sciences Medicine Medicine & Public Health Middle Aged Pathology Receptors, Calcitriol - genetics Receptors, Calcitriol - metabolism research-article Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Neoplasm - genetics RNA, Neoplasm - metabolism skin Skin Neoplasms - genetics Skin Neoplasms - metabolism Steroid Hydroxylases - genetics Tumors of the skin and soft tissue. Premalignant lesions vitamin D Vitamin D - analogs & derivatives Vitamin D - metabolism Vitamin D - pharmacology vitamin D receptor vitamin D-25-hydroxylase Vitamin D3 24-Hydroxylase
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