Comparison of HPV DNA vaccines employing intracellular targeting strategies

Intradermal vaccination via gene gun efficiently delivers DNA vaccines into dendritic cells (DCs) of the skin, resulting in the activation and priming of antigen-specific T cells in vivo. In the context of DNA vaccines, we previously used the gene gun approach to test several intracellular targeting...

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Veröffentlicht in:	Gene therapy 2004-06, Vol.11 (12), p.1011-1018
Hauptverfasser:	KIM, J. W, HUNG, C-F, WU, T-C, JUANG, J, HE, L, WOO KIM, T, ARMSTRONG, D. K, PAI, S. I, CHEN, P-J, LIN, C-T, BOYD, D. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Antigen presentation Antigen processing Antigens Antitumor activity Applied cell therapy and gene therapy Biolistics Biological and medical sciences Biotechnology Calreticulin Calreticulin - genetics CD8 antigen CD8-Positive T-Lymphocytes - immunology Cell Line, Tumor Clinical trials Dendritic cells Deoxyribonucleic acid DNA DNA vaccines Exotoxin A Female Fundamental and applied biological sciences. Psychology Gene Targeting Gene therapy Genetic Therapy - methods Health. Pharmaceutical industry Histocompatibility Antigens Class I - immunology Hsp70 protein Human papillomavirus Human papillomavirus 16 Humans Immune response (cell-mediated) Immunization Industrial applications and implications. Economical aspects Intracellular LAMP-1 protein Lymphocyte Activation Lymphocytes Lymphocytes T Major histocompatibility complex Medical sciences Membrane proteins Mice Mice, Inbred C57BL Mycobacterium tuberculosis Oncogene Proteins, Viral - genetics Papillomaviridae - genetics Papillomaviridae - immunology Papillomavirus E7 Proteins Papillomavirus Infections - immunology Papillomavirus Infections - therapy Pseudomonas aeruginosa Recombinant Proteins - administration & dosage Skin - immunology Transfusions. Complications. Transfusion reactions. Cell and gene therapy Tuberculosis Tumors Vaccines Vaccines, DNA - administration & dosage
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