R353Q Polymorphism, Activated Factor VII, and Risk of Premature Myocardial Infarction in Japanese Men
Background The association between myocardial infarction (MI) and the R353Q polymorphism of the Factor VII (FVII) gene, which reportedly influences FVII concentrations, activated Factor VII (FVIIa), or FVII antigen (FVIIag), remains controversial. Methods and Results The present case - control study...
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| Veröffentlicht in: | Circulation Journal 2004, Vol.68(6), pp.520-525 |
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| creator | Ogawa, Masakazu Abe, Satoshi Biro, Sadatoshi Saigo, Masahiko Kihara, Takashi Setoyama, Shiro Matsuoka, Tatsuru Toda, Hitoshi Torii, Hiroyuki Atsuchi, Yoshihiko Toyama, Yoshifumi Tateishi, Shigeki Minagoe, Shinichi Maruyama, Ikuro Tei, Chuwa |
| description | Background The association between myocardial infarction (MI) and the R353Q polymorphism of the Factor VII (FVII) gene, which reportedly influences FVII concentrations, activated Factor VII (FVIIa), or FVII antigen (FVIIag), remains controversial. Methods and Results The present case - control study in 127 Japanese men with their first MI at or before 45 years of age and 150 matched healthy controls was designed to clarify this association in premature MI. R353Q polymorphism was determined by polymerase chain reaction, and plasma concentrations of FVIIa and FVIIag were assayed. The distribution of the RR, RQ, and QQ genotypes with respect to R353Q polymorphism was 117, 10, and 0 in the patients, and 131, 17, and 2 in the controls. The Q allele was negatively associated with premature MI (odds ratio =0.41, p=0.038). The plasma concentration of FVIIa was slightly higher in patients (55.1±40.9 U/L) than in controls (44.8±20.2 U/L), but not significantly (p=0.078); the plasma concentration of FVIIag did not differ between patients (88.7±15.7%) and controls (87.0±9.0%) (p=0.557). Plasma FVIIa concentrations were influenced by R353Q polymorphism (p |
| doi_str_mv | 10.1253/circj.68.520 |
| format | Article |
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Methods and Results The present case - control study in 127 Japanese men with their first MI at or before 45 years of age and 150 matched healthy controls was designed to clarify this association in premature MI. R353Q polymorphism was determined by polymerase chain reaction, and plasma concentrations of FVIIa and FVIIag were assayed. The distribution of the RR, RQ, and QQ genotypes with respect to R353Q polymorphism was 117, 10, and 0 in the patients, and 131, 17, and 2 in the controls. The Q allele was negatively associated with premature MI (odds ratio =0.41, p=0.038). The plasma concentration of FVIIa was slightly higher in patients (55.1±40.9 U/L) than in controls (44.8±20.2 U/L), but not significantly (p=0.078); the plasma concentration of FVIIag did not differ between patients (88.7±15.7%) and controls (87.0±9.0%) (p=0.557). Plasma FVIIa concentrations were influenced by R353Q polymorphism (p<0.001). Conclusions The Q allele may be protective against premature MI. (Circ J 2004; 68: 520 - 525)</description><identifier>ISSN: 1346-9843</identifier><identifier>EISSN: 1347-4820</identifier><identifier>DOI: 10.1253/circj.68.520</identifier><identifier>PMID: 15170085</identifier><language>eng</language><publisher>Japan: The Japanese Circulation Society</publisher><subject>Adult ; Age of Onset ; Case-Control Studies ; Coronary risk factor ; DNA Mutational Analysis ; Factor VII ; Factor VIIa - analysis ; Factor VIIa - genetics ; Gene Frequency ; Genotype ; Humans ; Japan - epidemiology ; Male ; Myocardial Infarction - epidemiology ; Myocardial Infarction - etiology ; Myocardial Infarction - genetics ; Odds Ratio ; Polymorphism, Single Nucleotide ; Premature myocardial infarction ; R353Q polymorphism ; Risk</subject><ispartof>Circulation Journal, 2004, Vol.68(6), pp.520-525</ispartof><rights>2004 THE JAPANESE CIRCULATION SOCIETY</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c574t-9ef91f6bae50c8d5725c442097aaef33faf871d9ba4b0bade63d8583c3fd7c63</citedby><cites>FETCH-LOGICAL-c574t-9ef91f6bae50c8d5725c442097aaef33faf871d9ba4b0bade63d8583c3fd7c63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15170085$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ogawa, Masakazu</creatorcontrib><creatorcontrib>Abe, Satoshi</creatorcontrib><creatorcontrib>Biro, Sadatoshi</creatorcontrib><creatorcontrib>Saigo, Masahiko</creatorcontrib><creatorcontrib>Kihara, Takashi</creatorcontrib><creatorcontrib>Setoyama, Shiro</creatorcontrib><creatorcontrib>Matsuoka, Tatsuru</creatorcontrib><creatorcontrib>Toda, Hitoshi</creatorcontrib><creatorcontrib>Torii, Hiroyuki</creatorcontrib><creatorcontrib>Atsuchi, Yoshihiko</creatorcontrib><creatorcontrib>Toyama, Yoshifumi</creatorcontrib><creatorcontrib>Tateishi, Shigeki</creatorcontrib><creatorcontrib>Minagoe, Shinichi</creatorcontrib><creatorcontrib>Maruyama, Ikuro</creatorcontrib><creatorcontrib>Tei, Chuwa</creatorcontrib><title>R353Q Polymorphism, Activated Factor VII, and Risk of Premature Myocardial Infarction in Japanese Men</title><title>Circulation Journal</title><addtitle>Circ J</addtitle><description>Background The association between myocardial infarction (MI) and the R353Q polymorphism of the Factor VII (FVII) gene, which reportedly influences FVII concentrations, activated Factor VII (FVIIa), or FVII antigen (FVIIag), remains controversial. Methods and Results The present case - control study in 127 Japanese men with their first MI at or before 45 years of age and 150 matched healthy controls was designed to clarify this association in premature MI. R353Q polymorphism was determined by polymerase chain reaction, and plasma concentrations of FVIIa and FVIIag were assayed. The distribution of the RR, RQ, and QQ genotypes with respect to R353Q polymorphism was 117, 10, and 0 in the patients, and 131, 17, and 2 in the controls. The Q allele was negatively associated with premature MI (odds ratio =0.41, p=0.038). The plasma concentration of FVIIa was slightly higher in patients (55.1±40.9 U/L) than in controls (44.8±20.2 U/L), but not significantly (p=0.078); the plasma concentration of FVIIag did not differ between patients (88.7±15.7%) and controls (87.0±9.0%) (p=0.557). Plasma FVIIa concentrations were influenced by R353Q polymorphism (p<0.001). Conclusions The Q allele may be protective against premature MI. (Circ J 2004; 68: 520 - 525)</description><subject>Adult</subject><subject>Age of Onset</subject><subject>Case-Control Studies</subject><subject>Coronary risk factor</subject><subject>DNA Mutational Analysis</subject><subject>Factor VII</subject><subject>Factor VIIa - analysis</subject><subject>Factor VIIa - genetics</subject><subject>Gene Frequency</subject><subject>Genotype</subject><subject>Humans</subject><subject>Japan - epidemiology</subject><subject>Male</subject><subject>Myocardial Infarction - epidemiology</subject><subject>Myocardial Infarction - etiology</subject><subject>Myocardial Infarction - genetics</subject><subject>Odds Ratio</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Premature myocardial infarction</subject><subject>R353Q polymorphism</subject><subject>Risk</subject><issn>1346-9843</issn><issn>1347-4820</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1vEzEQhi0EoqVw44x84pQN9nr9sceoojSoqB-quFqz9pg67K6DvUHKv-_SROQyM9I882j0EvKRsyWvpfjiYnabpTJLWbNX5JyLRleNqdnrl1lVrWnEGXlXyoaxumWyfUvOuOSaMSPPCT4IKe7pXer3Q8rbp1iGBV25Kf6FCT29AjelTH-u1wsKo6cPsfymKdC7jANMu4z0xz45yD5CT9djgDyfppHGkX6HLYxYZgLH9-RNgL7gh2O_II9XXx8vr6ub22_ry9VN5aRupqrF0PKgOkDJnPFS19I1Tc1aDYBBiADBaO7bDpqOdeBRCW-kEU4Er50SF-TzQbvN6c8Oy2SHWBz2_fxI2hWreauU0O0MLg6gy6mUjMFucxwg7y1n9l-q9iVVq4ydU53xT0fvrhvQn-BjjDOwOgCbMsEv_A9AnqLr8WRThzJLT7snyBZH8Qy6sYun</recordid><startdate>2004</startdate><enddate>2004</enddate><creator>Ogawa, Masakazu</creator><creator>Abe, Satoshi</creator><creator>Biro, Sadatoshi</creator><creator>Saigo, Masahiko</creator><creator>Kihara, Takashi</creator><creator>Setoyama, Shiro</creator><creator>Matsuoka, Tatsuru</creator><creator>Toda, Hitoshi</creator><creator>Torii, Hiroyuki</creator><creator>Atsuchi, Yoshihiko</creator><creator>Toyama, Yoshifumi</creator><creator>Tateishi, Shigeki</creator><creator>Minagoe, Shinichi</creator><creator>Maruyama, Ikuro</creator><creator>Tei, Chuwa</creator><general>The Japanese Circulation Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2004</creationdate><title>R353Q Polymorphism, Activated Factor VII, and Risk of Premature Myocardial Infarction in Japanese Men</title><author>Ogawa, Masakazu ; Abe, Satoshi ; Biro, Sadatoshi ; Saigo, Masahiko ; Kihara, Takashi ; Setoyama, Shiro ; Matsuoka, Tatsuru ; Toda, Hitoshi ; Torii, Hiroyuki ; Atsuchi, Yoshihiko ; Toyama, Yoshifumi ; Tateishi, Shigeki ; Minagoe, Shinichi ; Maruyama, Ikuro ; Tei, Chuwa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c574t-9ef91f6bae50c8d5725c442097aaef33faf871d9ba4b0bade63d8583c3fd7c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Age of Onset</topic><topic>Case-Control Studies</topic><topic>Coronary risk factor</topic><topic>DNA Mutational Analysis</topic><topic>Factor VII</topic><topic>Factor VIIa - analysis</topic><topic>Factor VIIa - genetics</topic><topic>Gene Frequency</topic><topic>Genotype</topic><topic>Humans</topic><topic>Japan - epidemiology</topic><topic>Male</topic><topic>Myocardial Infarction - epidemiology</topic><topic>Myocardial Infarction - etiology</topic><topic>Myocardial Infarction - genetics</topic><topic>Odds Ratio</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Premature myocardial infarction</topic><topic>R353Q polymorphism</topic><topic>Risk</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ogawa, Masakazu</creatorcontrib><creatorcontrib>Abe, Satoshi</creatorcontrib><creatorcontrib>Biro, Sadatoshi</creatorcontrib><creatorcontrib>Saigo, Masahiko</creatorcontrib><creatorcontrib>Kihara, Takashi</creatorcontrib><creatorcontrib>Setoyama, Shiro</creatorcontrib><creatorcontrib>Matsuoka, Tatsuru</creatorcontrib><creatorcontrib>Toda, Hitoshi</creatorcontrib><creatorcontrib>Torii, Hiroyuki</creatorcontrib><creatorcontrib>Atsuchi, Yoshihiko</creatorcontrib><creatorcontrib>Toyama, Yoshifumi</creatorcontrib><creatorcontrib>Tateishi, Shigeki</creatorcontrib><creatorcontrib>Minagoe, Shinichi</creatorcontrib><creatorcontrib>Maruyama, Ikuro</creatorcontrib><creatorcontrib>Tei, Chuwa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ogawa, Masakazu</au><au>Abe, Satoshi</au><au>Biro, Sadatoshi</au><au>Saigo, Masahiko</au><au>Kihara, Takashi</au><au>Setoyama, Shiro</au><au>Matsuoka, Tatsuru</au><au>Toda, Hitoshi</au><au>Torii, Hiroyuki</au><au>Atsuchi, Yoshihiko</au><au>Toyama, Yoshifumi</au><au>Tateishi, Shigeki</au><au>Minagoe, Shinichi</au><au>Maruyama, Ikuro</au><au>Tei, Chuwa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>R353Q Polymorphism, Activated Factor VII, and Risk of Premature Myocardial Infarction in Japanese Men</atitle><jtitle>Circulation Journal</jtitle><addtitle>Circ J</addtitle><date>2004</date><risdate>2004</risdate><volume>68</volume><issue>6</issue><spage>520</spage><epage>525</epage><pages>520-525</pages><issn>1346-9843</issn><eissn>1347-4820</eissn><abstract>Background The association between myocardial infarction (MI) and the R353Q polymorphism of the Factor VII (FVII) gene, which reportedly influences FVII concentrations, activated Factor VII (FVIIa), or FVII antigen (FVIIag), remains controversial. Methods and Results The present case - control study in 127 Japanese men with their first MI at or before 45 years of age and 150 matched healthy controls was designed to clarify this association in premature MI. R353Q polymorphism was determined by polymerase chain reaction, and plasma concentrations of FVIIa and FVIIag were assayed. The distribution of the RR, RQ, and QQ genotypes with respect to R353Q polymorphism was 117, 10, and 0 in the patients, and 131, 17, and 2 in the controls. The Q allele was negatively associated with premature MI (odds ratio =0.41, p=0.038). The plasma concentration of FVIIa was slightly higher in patients (55.1±40.9 U/L) than in controls (44.8±20.2 U/L), but not significantly (p=0.078); the plasma concentration of FVIIag did not differ between patients (88.7±15.7%) and controls (87.0±9.0%) (p=0.557). Plasma FVIIa concentrations were influenced by R353Q polymorphism (p<0.001). Conclusions The Q allele may be protective against premature MI. (Circ J 2004; 68: 520 - 525)</abstract><cop>Japan</cop><pub>The Japanese Circulation Society</pub><pmid>15170085</pmid><doi>10.1253/circj.68.520</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age of Onset Case-Control Studies Coronary risk factor DNA Mutational Analysis Factor VII Factor VIIa - analysis Factor VIIa - genetics Gene Frequency Genotype Humans Japan - epidemiology Male Myocardial Infarction - epidemiology Myocardial Infarction - etiology Myocardial Infarction - genetics Odds Ratio Polymorphism, Single Nucleotide Premature myocardial infarction R353Q polymorphism Risk |
| title | R353Q Polymorphism, Activated Factor VII, and Risk of Premature Myocardial Infarction in Japanese Men |
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