Study on Affinity Profile toward Native Human and Bovine Adenosine Receptors of a Series of 1,8-Naphthyridine Derivatives

A new series of 1,8-naphthyridine derivatives (29−44 and 46−52) bearing various substituents in different positions on the heterocyclic nucleus were synthesized in order to analyze the effects produced on the affinity toward the bovine adenosine receptors. These derivatives represent an extension of...

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Veröffentlicht in:	Journal of medicinal chemistry 2004-06, Vol.47 (12), p.3019-3031
Hauptverfasser:	Ferrarini, Pier Luigi, Betti, Laura, Cavallini, Tiziana, Giannaccini, Gino, Lucacchini, Antonio, Manera, Clementina, Martinelli, Adriano, Ortore, Gabriella, Saccomanni, Giuseppe, Tuccinardi, Tiziano
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Biological and medical sciences Brain - drug effects Brain - metabolism Cattle Humans In Vitro Techniques Medical sciences Models, Molecular Naphthyridines - chemical synthesis Naphthyridines - chemistry Naphthyridines - pharmacology Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems Pharmacology. Drug treatments Radioligand Assay Receptors, Purinergic P1 - metabolism Structure-Activity Relationship
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